Diagnostic accuracy of red blood cell distribution width for neonatal sepsis

Liu, Zhiyuan; Jiang, Hui-Zhen; Wang, Li; Chen, Ming‐Xiao; Wang, Hong-Tao; Zhang, Jiaxiang

doi:10.23736/s2724-5276.21.06149-1

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Chronic inflammation and ROS stress can lead to increased RDW by suppressing effective bone marrow erythropoiesis, increasing red blood cell variability [49][50][51]. Oxidative stress decreases erythrocyte survival and leads to increased numbers of circulating premature erythrocytes, resulting in anisocytosis and higher RDW [52][53][54]. Therefore, high RDW may reflect chronic inflammation due to repeated chemotherapy, infection, and progressive underlying disease.…”

Section: Discussionmentioning

confidence: 99%

Utilizing red blood cell distribution width (RDW) as a reliable biomarker to predict treatment effects after chimeric antigen receptor T cell therapy

Nakamura,

Jo,

Arai

et al. 2024

Clin Exp Med

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Chimeric antigen receptor T cell (CAR-T) therapy is an effective treatment for B cell malignancies. A certain fraction of patients, however, experience post-CAR-T relapse, and due to the difficulty of precise relapse prediction, biomarkers that can predict the strength and duration of CAR-T efficacy are needed before CAR-T infusion. Therefore, we performed a single-center cohort study including 91 diffuse large B cell lymphoma (DLBCL) patients treated with CAR-T in order to identify such a new prognostic biomarker. After confirming that each of the already reported prognostic parameters (disease status at leukapheresis, primary refractoriness, number of treatment lines, CD3+ cell counts at leukapheresis) has only limited predictive performance, we established a new composite parameter by integrating these four variables, and found that it predicts progression-free survival (PFS) after CAR-T infusion with statistical significance. Moreover, after comprehensive correlation analyses of this new composite parameter with all individual laboratory variables, we determined that the standard deviation of red blood cell distribution width (RDW-SD) at leukapheresis shows significant correlation with the composite parameter and may be a prognostic biomarker (R2 = 0.76, p = 0.02). Validation analysis indicated that a higher RDW-SD is significantly associated with poorer PFS after CAR-T cell therapy (HR, 3.46, P = 0.03). Thus, this study suggests that a single parameter, RDW-SD at leukapheresis, is a novel, useful biomarker that can be obtained early to predict therapeutic effects of CAR-T cell therapy. Post-CAR-T maintenance or re-induction therapies should be adopted for higher risk patients, who may relapse after CAR-T therapy.

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Section: Discussionmentioning

confidence: 99%

Utilizing red blood cell distribution width (RDW) as a reliable biomarker to predict treatment effects after chimeric antigen receptor T cell therapy

Nakamura,

Jo,

Arai

et al. 2024

Clin Exp Med

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“…Various factors, including chronic fetal hypoxia in utero, infection, inflammation, physiological immaturity of blood cell production, hemolytic anemia, and erythrocyte transfusions, could lead to an elevated RDW in preterm neonates (4,8,9,30). An increased RDW mirrors a profound deregulation of erythrocyte homeostasis (42).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, RDW levels have been shown to be associated with neonatal mortality and/or significant morbidity, including neonatal sepsis, intrauterine growth restriction (IUGR), and bronchopulmonary dysplasia (BPD), etc., (8)(9)(10). The RDW has also been indicated as a useful tool for evaluating the medical conditions of newborns, especially preterm infants (11,12).…”

Section: Red Blood Cell Distribution Widthmentioning

confidence: 99%

Cross-sectional association between red blood cell distribution width and regional cerebral tissue oxygen saturation in preterm infants in the first 14 days after birth

Mu,

Wang,

Tian

et al. 2023

Front. Pediatr.

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BackgroundHypoxia can threaten the metabolic functions of different systems in immature neonates, particularly the central nervous system. The red blood cell distribution width (RDW) has recently been reported as a prognostic factor in neurologic diseases. Herein, we examined the correlation between RDW and regional cerebral tissue oxygen saturation (rcSO2).MethodsThis cross-sectional study included 110 preterm infants born at a gestational age (GA) of <32 weeks, or with a birth weight (BW) of <1,500 g at our institution between January and June 2,022. The rcSO2 was monitored using near-infrared spectroscopy, and RDW was extracted from the complete blood count during the first 14 days after birth. RDW and rcSO2 measurements were analyzed using a cross-sectional research method.ResultsWe divided the study population into two groups, with a mean rcSO2 value over the first 14 days. Fifty-three preterm had rcSO2 ≥ 55% and 57% < 55%. The 14-days-mean in the study population showing an association of lower rcSO2 values with higher RDW values. Significantly higher RDW values were observed in the low rcSO2 group compared with those in the high rcSO2 group. Threshold effect analysis showed that rcSO2 decreased with RDW values ≥18% (β, −0.03; 95% CI, −0.04 and −0.02; p ≥ 0.0001). After adjusting for potential confounders, an RDW of ≥18% was determined as the predictive cutoff value for preterm infants with low rcSO2 (Model I: OR, 3.31; 95% CI, 1.36–8.06; p = 0.009; and Model II: OR, 3.31; 95% CI, 1.28–8.53; p = 0.013).ConclusionsAn RDW of ≥18% in the first 14 days is associated with rcSO2 of <55% in preterm infants.

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Anisocytosis as a possible predictor of low cardiac output syndrome in children undergoing mitral valve surgery

Sobieraj,

Urbanowicz,

Olasińska – Wiśniewska

et al. 2024

Advances in Medical Sciences

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Diagnostic accuracy of red blood cell distribution width for neonatal sepsis

Cited by 5 publications

References 30 publications

Utilizing red blood cell distribution width (RDW) as a reliable biomarker to predict treatment effects after chimeric antigen receptor T cell therapy

Utilizing red blood cell distribution width (RDW) as a reliable biomarker to predict treatment effects after chimeric antigen receptor T cell therapy

Cross-sectional association between red blood cell distribution width and regional cerebral tissue oxygen saturation in preterm infants in the first 14 days after birth

Anisocytosis as a possible predictor of low cardiac output syndrome in children undergoing mitral valve surgery

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