Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease

Abstract

Background. Celiac disease (CD) is significantly underdiagnosed, despite significant efforts made in the last

Chocolate Consumers and Lymphocyte-to-Monocyte Ratio: A Working Hypothesis from a Preliminary Report of a Pilot Study in Celiac Subjects

“…One of the criteria for inclusion was the same number of subjects with NLR values over the cut off suggested by Sarikaya et al [12] in the two groups. Consistent with the high correlation between PLR and NLR, similar number of subjects (6/13 consumers, 7/13 non-consumers) had PLR higher than the suggested cut off (143.7) for celiac disease [13,14]. Therefore, we did not observe significant differences in PLR between the two groups.…”

“…Platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) have also been proposed as markers of inflammation in celiac disease [13,14] and acute ischemic stroke [15,16,17], and peripheral arterial [18], cardiovascular [19,20] and autoimmune [21] diseases. In particular, decreased LMR has been associated with increased disease activity in rheumatoid arthritis [21].…”

Hematologic Manifestations in Celiac Disease—A Practical Review

“…Anemia in CD patients is multifactorial in etiology; however, iron-deficiency anemia (IDA) is the most common reported [20]. Laboratory workup for IDA can reveal anemia, low mean corpuscular volume, low serum iron, low serum ferritin or anisocytosis (increased red blood cell distribution width) [21]. The main mechanism for IDA in CD is related to malabsorption, as the site of iron absorption—the proximal duodenum—is almost always involved [12].…”

Laboratory medicine in the era of precision medicine – dream or reality?

“…Complete blood count (CBC) derived parameters such as Mean Corpuscular Volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) are used routinely in clinical practice in the diagnosis of different type of anemias or hemoglobinopathy. Recently other/new CBC derivative parameters like platelet-to-lymphocyte ratio (PL/LY), neutrophil-to-lymphocyte ratio (PMN/LY) or red blood cell distribution width to lymphocyte count ratio (RDW/LY) have been proposed to be used for other purposes/pathologies and were verified also in the Romanian subpopulation as predictors for coronary chronic total occlusion in patients presenting with ST-segment elevation MI -PL/LY (17) to support proper clinical decision making in patients with high risk non-muscle invasive bladder cancer -PMN/ LY (18), or aiming at maximizing selection of those with the likelihood of celiac disease who shall benefit from confirmatory serologic tests (serum IgA anti-tissue transglutaminase 2 and anti-endomysial antibodies and duodenal biopsy) -RDW/LY (19). Patient stratification in cardio-cerebrovascular and metabolic disorders is on big demand nowadays; of the most challenging in biomarker development are prognostic markers associated with left ventricular dysfunction or remodeling (GDF-15, metalloproteinases MMP, TIMP and Gal-3 are promising markers).…”