Diagnostic accuracy of salivary gland ultrasound in Sjögren’s syndrome: A systematic review and meta-analysis

Ramsubeik, Karishma; Motilal, Shastri; Sánchez-Ramos, Luis; Ramrattan, Laurie Ann; Kaeley, Gurjit S.; Singh, Jasvinder A.

doi:10.1177/1759720x20973560

Cited by 25 publications

(6 citation statements)

References 89 publications

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“…Indeed, if Schirmer's test and sialometry are useful tools to assess lacrimal and salivary gland function, they cannot evaluate parenchymal abnormalities, which are detectable only by imaging techniques, such as ultrasonography and magnetic resonance imaging [11]. Many authors, such as Jousse-Joulin et al [12], Ramsubeik et al [13], and Lorenzon et al [14], have published about the role of SGUS in pSS. However, they focused mainly on the assessment of major salivary glands, with lacrimal glands receiving less attention.…”

Section: Discussionmentioning

confidence: 99%

Sonographic Appearance of Lacrimal Glands in Sjögren’s Syndrome at High Risk for Lymphoma Development

Giovannini,

Pegolo,

Longhino

et al. 2023

Cureus

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Primary Sjögren's syndrome (pSS) is an autoimmune systemic disease characterized by the destruction of exocrine glands, mainly salivary and lacrimal glands. The diagnosis is generally made upon objective tests aimed at assessing salivary and lacrimal glandular function, autoantibody assays, and the results of labial salivary gland biopsies. A major salivary gland biopsy is usually reserved to assess lymphoproliferative complications. Recently, the sonographic evaluation of the major salivary glands has gained a crucial role in assessing the glandular parenchyma and early detecting abnormalities, while the role of ultrasonography in the assessment of lacrimal glands is still secondary. Our case report is about a male patient who presented parotid gland swelling and purpuric lesions, with preserved salivary and lacrimal glandular function. Considering the presence of risk factors associated with lymphoproliferative development and the peculiar characteristics detected by salivary and lacrimal gland ultrasonography, we performed a parotid gland biopsy, confirming Sjögren's syndrome. Our case demonstrates that lacrimal gland ultrasonography could be implemented, along with major salivary gland ultrasonography, as a routine procedure in evaluating patients with suspected or definite diagnoses of pSS.

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Section: Discussionmentioning

confidence: 99%

Sonographic Appearance of Lacrimal Glands in Sjögren’s Syndrome at High Risk for Lymphoma Development

Giovannini,

Pegolo,

Longhino

et al. 2023

Cureus

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“…18,19 Studies have revealed adequate sensitivity and specificity regarding SGUS abnormalities in Sj€ ogren syndrome. 19,20…”

Section: Discussionmentioning

confidence: 99%

Childhood-Onset Sjögren Syndrome Presenting as Pulmonary Hemorrhage

Wang

Simpkin²,

Vielkind

et al. 2021

Pediatrics

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Primary Sjögren syndrome is an autoimmune disease characterized by inflammation of the salivary and lacrimal exocrine glands but can also present with systemic extraglandular manifestations, including pulmonary disease. Commonly described pulmonary manifestations of Sjögren syndrome include airway disease, interstitial lung disease, pulmonary arterial hypertension, and lymphoproliferative disorders. However, diffuse alveolar hemorrhage as a sequela of Sjögren syndrome has rarely been described in the adult literature and has never been described in a child. Here we report the case of an 11-year-old girl who presented with diffuse alveolar hemorrhage and was diagnosed with childhood-onset Sjögren syndrome who otherwise lacked typical clinical features, such as sicca symptoms, at the time of presentation. She was successfully treated with corticosteroids and rituximab, with sustained pulmonary remission 1 year post diagnosis. Our case highlights the heterogenous presentation of Sjögren syndrome in the pediatric population and the need for increased awareness among pediatric providers to recognize potential systemic manifestations of this disease to avoid delayed diagnosis.

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“…which was registered on PROSPERO ( (accessed on 1 February 2022)) (*registration number: CRD42021262596). In addition, the organization of the article is inspired by some high-quality studies [ 19 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

Diagnostic Value of Superb Microvascular Imaging in Differentiating Benign and Malignant Breast Tumors: A Systematic Review and Meta-Analysis

Feng

Jin

et al. 2022

Diagnostics

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Purpose: We performed a systematic review and meta-analysis of studies that investigated the diagnostic performance of Superb Microvascular Imaging (SMI) in differentiating between benign and malignant breast tumors. Methods: Studies published between January 2010 and March 2022 were retrieved by online literature search conducted in PubMed, Embase, Cochrane Library, Web of Science, China Biology Medicine Disc, China National Knowledge Infrastructure, Wanfang, and Vip databases. Pooled sensitivity, specificity, and diagnostic odd ratios were calculated using Stata software 15.0. Heterogeneity among the included studies was assessed using I2 statistic and Q test. Meta-regression and subgroup analyses were conducted to investigate potential sources of heterogeneity. Influence analysis was conducted to determine the robustness of the pooled conclusions. Deeks’ funnel plot asymmetry test was performed to assess publication bias. A summary receiver operating characteristic curve (SROC) was constructed. Results: Twenty-three studies involving 2749 breast lesions were included in our meta-analysis. The pooled sensitivity and specificity were 0.80 (95% confidence interval [CI], 0.77–0.84, inconsistency index [I2] = 28.32%) and 0.84 (95% CI, 0.79–0.88, I2 = 89.36%), respectively. The pooled diagnostic odds ratio was 19.95 (95% CI, 14.84–26.82). The area under the SROC (AUC) was 0.85 (95% CI, 0.81–0.87). Conclusion: SMI has a relatively high sensitivity, specificity, and accuracy for differentiating between benign and malignant breast lesions. It represents a promising supplementary technique for the diagnosis of breast neoplasms.

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Diagnostic accuracy of salivary gland ultrasound in Sjögren’s syndrome: A systematic review and meta-analysis

Cited by 25 publications

References 89 publications

Sonographic Appearance of Lacrimal Glands in Sjögren’s Syndrome at High Risk for Lymphoma Development

Sonographic Appearance of Lacrimal Glands in Sjögren’s Syndrome at High Risk for Lymphoma Development

Childhood-Onset Sjögren Syndrome Presenting as Pulmonary Hemorrhage

Diagnostic Value of Superb Microvascular Imaging in Differentiating Benign and Malignant Breast Tumors: A Systematic Review and Meta-Analysis

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