Diagnostic accuracy of sentinel lymph node biopsy using indocyanine green in lung cancer: a systematic review and meta-analysis

Sun, Warren; Dang, Jerry; Modasi, Aryan; Nasralla, Awrad; Switzer, Noah; Birch, Daniel W.; Turner, Simon R.; Karmali, Shahzeer

doi:10.1007/s11748-020-01400-8

Cited by 11 publications

(9 citation statements)

References 37 publications

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“…Previously, ICG-NIR imaging was often used to detect sentinel lymph nodes in solid tumours, demonstrating that ICG was more effective than other tracers ( 18 ). For example, Kawakami et al ( 19 ) found that the identification rate of ICG-NIR imaging for sentinel lymph nodes in lung cancer surgery was as high as 72.7%, and the high accuracy rate of this technique could be maintained throughout the follow-up period.…”

Section: Discussionmentioning

confidence: 99%

Indocyanine green near-infrared imaging-guided lymph node dissection during oesophageal cancer surgery: A single-centre experience

Chen

Tian

et al. 2023

Front. Surg.

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ObjectiveThis study aimed to investigate the feasibility of using indocyanine green (ICG) near-infrared (NIR) imaging during lymphadenectomy for oesophageal cancer.MethodsEighty-seven patients with primary oesophageal cancer were enrolled in this study. All the enrolled patients received an endoscopic injection of ICG between 40 min and 23 h before surgery. Nodal dissection during surgery was performed under fluorescence imaging visualisation, with the NIR signal shown in purple. ICG+ or ICG− nodes were recorded station by station and were microscopically evaluated.ResultsEndoscopic peritumoral ICG injection was successfully performed in all patients. Major post-surgery complications included wound infection, pleural effusion, dysphonia, pneumonia and anastomotic fistula. No patients experienced ICG-related adverse events. A total of 2,584 lymph nodes were removed, and the mean number of lymph nodes for each patient was 29.70 ± 9.24. Most of the removed nodes (97.83%) were ICG+, and 3.32% of the ICG+ nodes were metastatic. No metastatic nodes were ICG− or belonged to an ICG− lymph node station. The time from ICG injection to surgery did not affect the number of harvested lymph nodes.ConclusionsThe use of ICG-NIR imaging during oesophageal cancer surgery can enhance the visualisation of lymph nodes during surgery. It is a feasible, safe and helpful technique for lymphadenectomy.

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Section: Discussionmentioning

confidence: 99%

Indocyanine green near-infrared imaging-guided lymph node dissection during oesophageal cancer surgery: A single-centre experience

Chen

Tian

et al. 2023

Front. Surg.

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“…In der Humanmedizin gilt als Standard für die präoperative Beurteilung der Lymphknoten die Positronen-Emissions-Tomographie (PET)/CT und/oder die endoskopisch- oder endobronchialultrasonographisch gestützte Feinnadelaspirationsbiopsie 41 , 42 , 43 . Die Indocyaningrün-Fluoroskopie ergab suboptimale Ergebnisse für die diagnostische Beurteilung der tributären Lymphknoten und ist somit für einen routinemäßigen klinischen Einsatz noch nicht geeignet 44 . Da diese Verfahren in der Veterinärmedizin noch nicht routinemäßig verfügbar sind, erfordert die Entwicklung eines zuverlässigen Protokolls für die präoperative Beurteilung der TBLN bei Hunden weitere Forschung.…”

Section: Diskussionunclassified

Klinisch-pathologische Befunde, postoperative Überlebenszeiten und prognostische Faktoren bei Hunden mit primären Lungenkarzinomen

Plavec¹,

Žagar²,

Kessler³

2022

Tierarztl Prax Ausg K Kleintiere Heimtiere

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Zusammenfassung Einleitung Primäre Karzinome der Lunge (PLK) beim Hund sind selten, ihre Behandlung erfolgt chirurgisch. Ziel dieser Studie war die Untersuchung klinisch-pathologischer Befunde, postoperativer medianer Überlebenszeiten (mÜZ) und prognostischer Faktoren. Material und Methoden Retrospektive Auswertung von 61 Hunden mit 62 PLK, die zwischen 2007 und 2017 chirurgisch behandelt wurden. Die statistische Auswertung erfolgte mittels Kaplan-Meier und Logrank Methoden. Ergebnisse Von 62 PLKs lagen 35 (56 %) peripher im Lungenlappen, 21 (34 %) hilusnah und 6 (10 %) betrafen den gesamten Lungenlappen. In 49 Fällen lagen differenzierte Adenokarzinome vor; niedrig differenzierte bzw. anaplastische Karzinome (n = 10) und Plattenepithelkarzinome (n = 2) waren deutlich seltener. Eine Prädisposition für bestimmte Lungenlappen war nicht nachzuweisen. Dreizehn (21 %) Patienten zeigten keine und 10 (16 %) nur unspezifische, nicht auf den Respirationstrakt hinweisende Symptome. Insgesamt zeigten 48 (79 %) Hunde klinische Symptome wie Husten, Dyspnoe, Lethargie, Gewichtsverlust, Leistungsschwäche, Erbrechen und/oder Fieber. Die tracheobronchialen Lymphknoten (TBLN) waren in 9 von 51 untersuchten Fällen histologisch positiv für Metastasierung (N1) und negativ (N0) in 42 Fällen (nicht untersucht n = 10). Daten zum Langzeitverlauf waren für 50 Patienten verfügbar. Prognostisch relevante Variablen waren Lymphknotenmetastasierung in die TBLN (mÜZ: N1 41 Tage, N0 570 Tage; p < 0,01), Lungenmetastasen (mÜZ: M1 125 Tage, M0 630 Tage; p < 0,01), histologischer Subtyp (mÜZ: differenzierte Karzinome 620 Tage; andere Karzinome 135 Tage; p < 0,01), Tumordurchmesser größer als 3 cm (mÜZ < 3 cm 1155 Tage, ≥ 3 cm 330 Tage; p = 0,02) und Tumorlokalisation (mÜZ: hilusnah 330 Tage, peripher 650 Tage; p = 0,04). Schlussfolgerung Beim PLK sind TBLN Status, Organmetastasen, Tumorlokalisation, histologischer Subtyp und Tumorgröße prognostisch relevante Kriterien. Hunde ohne prognostisch negative Faktoren können lange Überlebenszeiten aufweisen. In mehr als einem Drittel der Fälle bleiben die Tumoren asymptomatisch (21 %) bzw. ohne respirationstraktspezifische (16 %) Symptome.

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“…99m Tc-nanocolloïd and/or indocyanine green (ICG) are most often used, but other methods can also be applied (7). The literature on SLN procedures in lung cancer by radioactive tracers or ICG suggests an identification rate of around 90%, while varying approaches are reported (8)(9)(10). Despite this published success, an SLN procedure has not been implemented into routine surgical treatment, mainly due to the complexity and lack of clinical consequences since lobectomy still is the cornerstone of curative surgery (11).…”

Section: Introductionmentioning

confidence: 99%

“…Since an SLN procedure is not part of clinical practice for lung cancer, no standardized protocol has been established. The need for a robust and accurate protocol to standardize the injection, identification and dissection of SLN has been addressed by multiple authors in the past (10,12,13). This will be essential to determine the added value of an SLN procedure in lung cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Ex-vivo exploration of an endobronchial sentinel lymph node procedure in lung cancer for optimizing workflow and evaluating feasibility of novel imaging tools

Woerds¹,

Verhoeven²,

Heide³

et al. 2023

J Thorac Dis

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Contributions: (I) Conception and design: DKM ter Woerds, RLJ Verhoeven, EHJG Aarntzen, EHFM van der Heijden; (II) Administrative support: SM van der Heide, AFTM Verhagen; (III) Provision of study materials or patients: SM van der Heide, AFTM Verhagen; (IV) Collection and assembly of data: DKM ter Woerds, RLJ Verhoeven, EHJG Aarntzen, EHFM van der Heijden; (V) Data analysis and interpretation: DKM ter Woerds, RLJ Verhoeven, EHJG Aarntzen, EHFM van der Heijden;

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Diagnostic accuracy of sentinel lymph node biopsy using indocyanine green in lung cancer: a systematic review and meta-analysis

Cited by 11 publications

References 37 publications

Indocyanine green near-infrared imaging-guided lymph node dissection during oesophageal cancer surgery: A single-centre experience

Indocyanine green near-infrared imaging-guided lymph node dissection during oesophageal cancer surgery: A single-centre experience

Klinisch-pathologische Befunde, postoperative Überlebenszeiten und prognostische Faktoren bei Hunden mit primären Lungenkarzinomen

Ex-vivo exploration of an endobronchial sentinel lymph node procedure in lung cancer for optimizing workflow and evaluating feasibility of novel imaging tools

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