Diagnostic Accuracy of Serological Markers in Viral Hepatitis and Non Alcoholic Fatty Liver Disease. A Comparative Study in Tertiary Care Hospital of Western Nepal

Mittal, Ankush; Sathian, Brijesh; Chandrasekharan, N; Lekhi, Akshay; Farooqui, Shamim Mohammad; Pandey, Naresh

doi:10.3126/nje.v1i2.5137

Cited by 9 publications

(9 citation statements)

References 15 publications

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“…The finding of De Ritis ratio 1.2204 ± 0.17954 (p = 0.005) in patients with NAFLD in our study suggests the presence of fibrosis or cirrhosis, which is not consistent with the study done by Mittal in 2011 at Manipal College of Medical Sciences, Pokhara, Nepal. [16] The disparity of result because the patient at Manipal Medical College may be in initial stage of NAFLD (steatosis), before advancement of fibrosis and cirrhosis.…”

Section: Mean Of De Ritis Ratio Was Compared Between Control and Eachmentioning

confidence: 99%

Evaluation of De Ritis ratio in liver-associated diseases

Parmar¹,

Singh²,

Gupta³

et al. 2016

Int J Med Sci Public Health

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Background: Liver diseases are one of the common disorders encountered in clinical practice. Investigations in liverassociated diseases are used to detect type of hepatic abnormality, to measure its severity, to define its structural effect on the liver, to find out etiology of disorder, to assess prognosis, and to evaluate therapy. One should aim at a diagnosis with simple and possibly noninvasive means, avoiding extensive examinations. De Ritis ratio (the ratio of serum aspartate aminotransferase to serum alanine aminotransferase) has been proposed a valuable diagnostic marker to screen liver disorder. Objective: To assess the significance of De Ritis ratio as a diagnostic marker in population of hepatic disorder. Materials and Method: This is a retrospective study performed on records of 102 patients with liver diseases who were treated at the outpatient clinic or admitted to Nobel Medical College, Biratnagar, Nepal, between June 15, 2015 and July 15, 2015. De Ritis ratio of all the patients were calculated from documented biochemical tests of AST and ALT. De Ritis ratio and demographic profile of all the patients were analyzed by independent t-test and one-way ANOVA using software SPSS 20 version. Results: De Ritis ratio was significantly decreased (p < 0.05) in viral hepatitis (0.8006 ± 0.14811) than the control group (1.0934 ± 0.13508) and markedly increased (p = 0.000) in alcoholic liver disorder. Similarly, It is significantly increased (p < 0.05) in nonalcoholic fatty liver disorder (1.2204 ± 0.17954), whereas insignificantly increased (p = 0.408) in cholestasis (1.1378 ± 0.18045). Conclusion: De Ritis ratio can be used as a prognostic marker of liver disorder and can be considered as a noninvasive, cost-effective means of screening liver diseases.

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Section: Mean Of De Ritis Ratio Was Compared Between Control and Eachmentioning

confidence: 99%

Evaluation of De Ritis ratio in liver-associated diseases

Parmar¹,

Singh²,

Gupta³

et al. 2016

Int J Med Sci Public Health

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“…A study by Mittal et al 86 at Pokhara, Nepal reported that the prevalence of NAFLD was 17%. Mild-to-moderate elevations in serum levels of aspartate aminotransferase (43.42–49.49 IU/L) and ALT (43.90–53.92 IU/L) were the most common laboratory abnormalities found in patients with NAFLD.…”

Section: Prevalence and Association In Different South Asian Countrymentioning

confidence: 98%

Nonalcoholic Fatty Liver Disease in South Asia

Pati

Singh

2010

Euroasian Journal of Hepato-Gastroenterology

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the West, and is also increasing alarmingly in South Asia, reaching an epidemic proportion of 30% because of epidemic of obesity and metabolic syndrome (MS) in younger South Asians in the last two decades. Prevalence of MS and fatty liver is escalating in geometric progression in South Asian countries, such as India, Pakistan, Sri Lanka, Bangladesh, Nepal, Bhutan, Burma, and Maldives because of sedentary lifestyle, poor health awareness, socioeconomic growth, affluence, urbanization, and dietary westernization. Almost 20% of world’s population resides in South Asia, making it the most populous and most densely populated geographic region in the world, thereby having most of MS and NAFLD cases within its territory. The risk factors and course of NAFLD do not differ between South Asians and other ethnic populations, but the obesity epidemic is more recent in South Asia than elsewhere in the world. Nonalcoholic fatty liver disease may progress through stages of simple bland steatosis, nonalcoholic steatohepatitis (NASH), hepatic fibrosis, cirrhosis, and finally hepatocellular carcinoma (HCC). It is frequently associated with obesity, MS, dyslipidemia, insulin resistance (IR), and type-2 diabetes mellitus (DM). Nonalcoholic fatty liver disease is frequently diagnosed with abdominal ultrasonography (US) study. Despite its high prevalence in the community till now, no definitive pharmacotherapy is available for NAFLD. However, modification of risk factors, such as dyslipidemia, control of diabetes, and weight reduction do help to some extent. The nonobese South Asians are also at increased risk of having NAFLD and NASH as, despite of absence of frank obesity in South Asians, they are metabolically more obese compared to other ethnic population and more prone to develop NAFLD-related complications. Therefore, the cost-effective US abdomen should be included in the list of tests for persons undergoing preemployment or master health checkups for early diagnosis of NAFLD in this resource-constraint South Asian region, so that early necessary measures can be undertaken to reduce NAFLD associated morbidity and mortality in the community.How to cite this articlePati GK, Singh SP. Nonalcoholic Fatty Liver Disease in South Asia. Euroasian J Hepato-Gastroenterol 2016;6(2):154-162.

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“…A few years ago we conducted a bibliographic review of health and medical publications in English of research conducted in Nepal, and the majority of this research was quantitative 17 , which is good for a journal like Nepal Journal of Epidemiology, but like in many low-income countries there is a need for further research capacity building [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] .…”

Section: Editorialmentioning

confidence: 99%

Role of Individual Academics and International Universities in Health Research in Nepal

Simkhada

Teijlingen

2012

Nepal J Epidemiology

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Nepal has made progress in health sciences and medical education over the past decade. We believe that there is a need in Nepal for a greater research emphasis on mixed-methods approaches, qualitative research, critical appraisal & systematic reviewing and health economics. Specifically to the discipline of epidemiology, Nepal should consider establishing more and better epidemiological studies, the kind of population-based studies that can identify risk factors, track changes over time at a population level over the decades to come. We know how important such long-term research is but we are also painfully aware how expensive this kind on long-term research can be.DOI: http://dx.doi.org/10.3126/nje.v2i2.6572 Nepal Journal of Epidemiology 2012;2(2):179-81

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Diagnostic Accuracy of Serological Markers in Viral Hepatitis and Non Alcoholic Fatty Liver Disease. A Comparative Study in Tertiary Care Hospital of Western Nepal

Cited by 9 publications

References 15 publications

Evaluation of De Ritis ratio in liver-associated diseases

Evaluation of De Ritis ratio in liver-associated diseases

Nonalcoholic Fatty Liver Disease in South Asia

Role of Individual Academics and International Universities in Health Research in Nepal

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