Diagnostic accuracy of shear wave elastography for endometrial cancer: A meta-analysis

Abstract

Background: This meta-analysis aimed to identify the accuracy of shear wave elastography (SWE) in the diagnosis of endometrial cancer (EC). Methods: We searched the PubMed, Cochrane Library, and chinese biomedical literature database from inception to September 30, 2022. Meta-analysis was conducted using STATA version 14.0 and Meta-Disc version 1.4 software. We calculated summary statistics for sensitivity (Sen), specificity (Spe), positive and negative likelihood ratio (LR+/LR−), diagnostic odds ratio (DOR), and receiver operating characteristic (SROC) curves. Results: Eight studies that met all the inclusion criteria were included in this meta-analysis. A total of 432 patients with EC and 548 with benign endometrial lesions were assessed. All endometrial lesions were histologically confirmed by SWE. The pooled Sen was 0.91 (95% confidence interval [CI] = 0.83–0.95); the pooled Spe was 0.90 (95% CI = 0.86–0.93); the pooled LR+ was 9.10 (95% CI = 6.20–13.35); the pooled negative LR− was 0.10 (95% CI = 0.05–0.20); the pooled DOR of SWE in the diagnosis of EC was 90.73 (95% CI = 36.62–804.5). The area under the SROC curve was 0.95 (95% CI = 0.93–0.97). No evidence of publication bias was found (t = 0.98, P = .37). Conclusion: Our meta-analysis indicates that SWE may have high diagnostic accuracy in the differential diagnosis of benign and malignant endometrial lesions. Thus, SWE may be a useful tool for the diagnosis of EC.

Could real-time sonoelastography-measured placental strain ratio (PSR) value be a soft marker for the diagnosis of intrahepatic cholestasis of pregnancy?: A case-control study and short reviews

“…However, we could not find any studies on the diagnostic effectiveness of shear wave elastography for placental function. Generally, they focused on malignancy, mostly other systems, and fewer gynecological issues, commonly in endometrial cancer [46] and pelvic floor. [47] In this sense, performing our study with strain elastography instead of shear-wave elastography can be considered as the second limitation of our study.…”

“…The findings of placental elastography thickness predicting cholestasis and the distribution of the patients with and without cholestasis by determined cutoff value. focused on malignancy, mostly other systems, and fewer gynecological issues, commonly in endometrial cancer [46] and pelvic floor. [47] In this sense, performing our study with strain elastography instead of shear-wave elastography can be considered as the second limitation of our study.…”

Ultrasonic shear-wave elastography: a novel method for assessing the tumor grade in endometrial cancer: a prospective study

“…13,14,17-19 Also a recent meta-analysis showed that SWE may have high diagnostic accuracy for the differential diagnosis of benign and malignant endometrial diseases. 20 In our study we also investigated the diagnostic performance of the shearwave elastography in endometrial cancer patients in terms of the histologic grade of the tumor. In our study, we found that patients with grade 3 EC had higher shearwave values compared to grade 1 and 2 patients 101.89 kPa, 13.52 kPa, 33.24 kPa, respectively (p<0.001).…”

“…In the literature many studies conducted with transvaginal probe. 20,34 In this study we used abdominal real-time shearwave elastography. Abdominal wall fat has impact on measurement, so the impact of BMI on patients has not been studied, and it will be further explored in subsequent studies.…”