Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens

Kani, Yukitaka; Cecere, Thomas E.; Lahmers, Kevin K.; LeRoith, Tanya; Zimmerman, Kurt; Isom, Scott; Hsu, Fang‐Chi; Debinksi, Waldemar; Robertson, John L.; Rossmeisl, John H.

doi:10.1111/jvim.15500

Cited by 25 publications

(53 citation statements)

References 22 publications

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“…Several SBB techniques have been utilized in dogs with brain tumors including endoscopic assisted, free-hand, and image-guided procedures. SBB associated diagnostic yields, morbidity, and mortality are variable and dependent on the technique used, the neurologic status of the patient, experience of the surgeon, and the neuroanatomic location of the lesion (68–74). However, similar to the human experience, when SBB is performed in dogs with brain tumors by an experienced veterinary neurosurgeons, diagnostic yields are 95%, and serious adverse events occur in <5% of cases (72, 74).…”

Section: Diagnosis Of Intracranial Tumorsmentioning

confidence: 99%

Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors

2019

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In the dog, primary intracranial neoplasia represents ~2–5% of all cancers and is especially common in certain breeds including English and French bulldogs and Boxers. The most common types of primary intracranial cancer in the dog are meningioma, glioma, and choroid plexus tumors, generally occurring in middle aged to older dogs. Much work has recently been done to understand the characteristic imaging and clinicopathologic features of these tumors. The gross and histologic landscape of these tumors in the dog compare favorably to their human counterparts with many similarities noted in histologic patterns, subtype, and grades. Data informing the underlying molecular abnormalities in the canine tumors have only begun to be unraveled, but reveal similar pathways are mutated between canine and human primary intracranial neoplasia. This review will provide an overview of the clinicopathologic features of the three most common forms of primary intracranial cancer in the dog, delve into the comparative aspects between the dog and human neoplasms, and provide an introduction to current standard of care while also highlighting novel, experimental treatments that may help bridge the gap between canine and human cancer therapies.

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Section: Diagnosis Of Intracranial Tumorsmentioning

confidence: 99%

Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors

2019

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“…Neurosurgical biopsies during craniotomy are the current standard used to obtain genomic information about glioma. However, a single biopsy is unlikely to represent the full set of mutations present in the cancer due to high tumor genomic and histological heterogeneity (7)(8)(9). Therefore, there is a need to develop a method that can reflect the global characteristics of gliomas which is robust to regional variation and provides clinically actionable conclusions.…”

Section: Introductionmentioning

confidence: 99%

Radiomics Features Predict CIC Mutation Status in Lower Grade Glioma

et al. 2020

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MRI in combination with genomic markers are critical in the management of gliomas. Radiomics and radiogenomics analysis facilitate the quantitative assessment of tumor properties which can be used to model both molecular subtype and predict disease progression. In this work, we report on the Drosophila gene capicua (CIC) mutation biomarker effects alongside radiomics features on the predictive ability of CIC mutation status in lower-grade gliomas (LGG). Genomic data of lower grade glioma (LGG) patients from The Cancer Genome Atlas (TCGA) (n = 509) and corresponding MR images from TCIA (n = 120) were utilized. Following tumor segmentation, radiomics features were extracted from T1, T2, T2 Flair, and T1 contrast enhanced (CE) images. Lasso feature reduction was used to obtain the most important MR image features and then logistic regression used to predict CIC mutation status. In our study, CIC mutation rarely occurred in Astrocytoma but has a high probability of occurrence in Oligodendroglioma. The presence of CIC mutation was found to be associated with better survival of glioma patients (p < 1e−4, HR: 0.2445), even with co-occurrence of IDH mutation and 1p/19q co-deletion (p = 0.0362, HR: 0.3674). An eleven-feature model achieved glioma prediction accuracy of 94.2% (95% CI, 94.03-94.38%), a six-feature model achieved oligodendroglioma prediction accuracy of 92.3% (95% CI, 91.70-92.92%). MR imaging and its derived image of gliomas with CIC mutation appears more complex and non-uniform but are associated with lower malignancy. Our study identified CIC as a potential prognostic factor in glioma which has close associations with survival. MRI radiomic features could predict CIC mutation, and reflect less malignant manifestations such as milder necrosis and larger tumor volume in MRI and its derived images that could help clinical judgment.

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“…[23][24][25][26] The high application accuracy of the device presented here was achieved by rigid fixation of the biopsy device to the skull using bone anchors. Therefore, it does not allow any movement between the device and skull that can potentially occur when using a bite plate 11,[13][14][15][16][17]19,21 or a face mask. 18 In accordance with the results, the MRI-based personalized, 3D…”

Section: Discussionmentioning

confidence: 99%

“…Stereotactic brain biopsy devices are often considered superior to an open surgical approach as they minimize injuries to the brain and surrounding tissues during the biopsy procedure . In the last 2 decades, several CT‐ and MRI‐guided stereotactic brain biopsy devices have been developed for veterinary use …”

Section: Introductionmentioning

confidence: 99%

“…11 In the last 2 decades, several CT-and MRI-guided stereotactic brain biopsy devices have been developed for veterinary use. 5,[7][8][9][11][12][13][14][15][16][17][18][19][20][21] The CT-guided modified Pelorus Mark III stereotactic system was 1 of the first biopsy devices in veterinary medicine. The mean needle placement error is determined to be 3.5 mm (SD: 1.6 mm).…”

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confidence: 99%

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Accuracy of a magnetic resonance imaging‐based 3D printed stereotactic brain biopsy device in dogs

Gutmann

Winkler

Müller

et al. 2020

Veterinary Internal Medicne

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Background Brain biopsy of intracranial lesions is often necessary to determine specific therapy. The cost of the currently used stereotactic rigid frame and optical tracking systems for brain biopsy in dogs is often prohibitive or accuracy is not sufficient for all types of lesion. Objectives To evaluate the application accuracy of an inexpensive magnetic resonance imaging‐based personalized, 3D printed brain biopsy device. Animals Twenty‐two dog heads from cadavers were separated into 2 groups according to body weight (<15 kg, >20 kg). Methods Experimental study. Two target points in each cadaver head were used (target point 1: caudate nucleus, target point 2: piriform lobe). Comparison between groups was performed using the independent Student's t test or the nonparametric Mann‐Whitney U Test. Results The total median target point deviation was 0.83 mm (range 0.09‐2.76 mm). The separate median target point deviations for target points 1 and 2 in all dogs were 0.57 mm (range: 0.09‐1.25 mm) and 0.85 mm (range: 0.14‐2.76 mm), respectively. Conclusion and Clinical Importance This magnetic resonance imaging‐based 3D printed stereotactic brain biopsy device achieved an application accuracy that was better than the accuracy of most brain biopsy systems that are currently used in veterinary medicine. The device can be applied to every size and shape of skull and allows precise positioning of brain biopsy needles in dogs.

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Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens

Cited by 25 publications

References 22 publications

Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors

Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors

Radiomics Features Predict CIC Mutation Status in Lower Grade Glioma

Accuracy of a magnetic resonance imaging‐based 3D printed stereotactic brain biopsy device in dogs

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