Diagnostic Accuracy of the Matrix 24-2 and Original N-30 Frequency-Doubling Technology Tests Compared with Standard Automated Perimetry

Racette, Lyne; Medeiros, Felipe A.; Zangwill, Linda M.; Ng, Diana; Weinreb, Robert N.; Sample, Pamela A.

doi:10.1167/iovs.07-0493

Cited by 46 publications

(39 citation statements)

References 27 publications

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“…Future studies should include results of the FDT Matrix, which has a higher spatial resolution. 43 Our results indicate that additional determination of morphometric integrity in this case RNFL thickness assessed by SDOCT can be justified especially in early diagnosis; in preperimetric patients the sensitivity of SDOCT is considerable higher than sensitivity of the presently used FDT perimeter. In more advanced stages of glaucoma the diagnostic value of both devices seem to be comparable.…”

Section: Discussionmentioning

confidence: 67%

Frequency doubling technique perimetry and spectral domain optical coherence tomography in patients with early glaucoma

Horn

Mardin

Bendschneider

et al. 2010

Eye

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Section: Discussionmentioning

confidence: 67%

Frequency doubling technique perimetry and spectral domain optical coherence tomography in patients with early glaucoma

Horn

Mardin

Bendschneider

et al. 2010

Eye

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“…We found higher mean values in the eye with Akreos AO in all areas (A1 to A4), but a statistical difference (P=0.043) was found only in the 20 o field area (A3). Although the chan ges were not statistically significant, it is noteworthy that an improvement in the perimetry values with such lenses could mask the diagnosis of glaucoma or lead to other diagnostic confusions, especially considering that the functional abnormalities detected by FDT perimetry were shown to be predictive of the future onset and location of VF loss among suspected glaucoma patients (13)(14)(15) . The results of the present study indicate that MD values were higher in the Akreos AO group, and the PSD was higher in the Akreos Fit group.…”

Section: Discussionmentioning

confidence: 87%

“…Maddess et al (12) proposed that a CS test based on the frequency-doubling illusion should be effective in the detection of early glaucomatous VF loss. However, previous studies have yielded divergent views regarding the diagnostic performance of FDT perimetry to standard automatic white-on-white perimetry (SAP) for the detection of glaucoma (13)(14)(15) . Because previous studies have demonstrated an improvement in CS in eyes implanted with aspheric IOLs (6)(7)(8)(9)(10) , is important to investigate its influence on the results of FDT.…”

Section: Introductionmentioning

confidence: 99%

Influence of aspheric intraocular lens on frequency doubling technology and contrast sensitivity: a fellow eye study

Espíndola

Santhiago

Monteiro

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate whether implantation of an aspheric intraocular lens (IOL) results in reduced ocular aberrations and improved contrast sensitivity after cataract surgery and, therefore, changes on frequency-doubling technology (FDT) testing. Methods: The present prospective clinical study enrolled 25 patients with bilateral cataract (50 eyes), who randomly received either an aspheric (Akreos AO) or a spherical (Akreos Fit) IOL in one eye and the other IOL in the second eye. Assessment 12 months postoperatively included photopic and mesopic contrast sensitivity testing. Higher-order aberrations (HOAs) were computed. FDT testing was divided into four areas to evaluate the variation of the values at different points. The median values of the local pattern thresholds (median area contrast sensitivity [MACS]) obtained with that division were calculated. Results: The Akreos AO group obtained statistically significantly lower values of HOAs and spherical aberration compared with the Akreos Fit group. There was a statistically significant between-group difference in contrast sensitivity under mesopic conditions at all spatial frequencies. No statistically significant differences were observed in mean deviation and pattern standard deviation. The aspheric IOL exhibited higher MACS in all areas, although a statistically significant difference was reached only in the 20-degree field area (P=0.043). Conclusions: Aspheric IOLs significantly reduced spherical aberration and HOAs, improving mesopic contrast sensitivity. Although there was a trend toward slightly improved FDT in the aspheric IOL group, it was not statistically significant.

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“…Similar to SAP, FDT Matrix also provides raw sensitivity values, total and pattern deviation probability plots, and the summary indices of MD and PSD. Matrix FDT has been reported by some to be better than SAP for discriminating glaucomatous and healthy eyes (Racette et al, 2008); however, others found no difference between Matrix FDT and SAP (Spry et al, 2005). SWAP has also been modified over the years and now utilizes the SITA strategy to shorten the test duration.…”

Section: Figurementioning

confidence: 99%

Strategies to improve early diagnosis in glaucoma

Tatham¹,

Medeiros²,

Zangwill³

et al. 2015

Progress in Brain Research

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Early diagnosis and treatment of glaucoma is important to reduce the risk of progressive and irreversible visual loss. The key to diagnosis is recognition of morphological changes to the optic nerve head and retinal nerve fiber layer, but in some patients, functional abnormalities are detected first. This review describes recent innovations with the potential to improve the early detection of glaucoma. Developments in imaging include novel optic nerve head metrics such as Bruch's membrane opening-minimum rim width, enhanced ability to quantify inner layers of the glaucomatous macula, and ability to image deep optic nerve head structures, including the lamina cribrosa. Developments in detection of early glaucomatous functional loss include novel perimetric tests using frequency-doubling technology and flicker-defined form stimuli. Methods to combine results of structural and functional assessments are also presented that may improve early detection of glaucoma. KeywordsGlaucoma, Optical coherence tomography, OCT, Perimetry, Spectral domain, Early diagnosis Glaucoma is a leading cause of blindness, affecting more than 70 million people worldwide, of whom approximately 10% are bilaterally blind (Quigley and Broman, 2006). Glaucomatous visual losses can be prevented with early diagnosis and treatment; however, affected individuals are typically asymptomatic until later stages of the disease and a large proportion of those affected remain undiagnosed. Population-level surveys suggest only 10-50% of people with glaucoma are aware that they have the condition and consequently there are a large number of people Progress in Brain Research, Volume 221, ISSN 0079-6123, http://dx

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Diagnostic Accuracy of the Matrix 24-2 and Original N-30 Frequency-Doubling Technology Tests Compared with Standard Automated Perimetry

Cited by 46 publications

References 27 publications

Frequency doubling technique perimetry and spectral domain optical coherence tomography in patients with early glaucoma

Frequency doubling technique perimetry and spectral domain optical coherence tomography in patients with early glaucoma

Influence of aspheric intraocular lens on frequency doubling technology and contrast sensitivity: a fellow eye study

Strategies to improve early diagnosis in glaucoma

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