Diagnostic accuracy of two endocervical sampling method: randomized controlled trial

Goksedef, Behiye Pinar Cilesiz; Apı, Murat; Kaya, Onur; Görgen, Hüsnü; Tarlaci, Ahmet; Çetin, Ahmet

doi:10.1007/s00404-012-2542-9

Cited by 17 publications

(21 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is interesting to note that in our study we conclude the exact opposite: one of the reasons for the better adequacy in our specimens of the ECB groups is the tendency of the physicians to apply an increased pressure during the procedure due to the perception of decreased pain in this group of patients. Goksedef et al [ 7 ] is the final study that found a benefit in the use of ECC compared to ECB. They prospectively randomized 208 patients to either ECB or ECC.…”

Section: Discussionmentioning

confidence: 99%

“…One of the fundamental steps in the diagnosis of dysplasia and cervical cancer is colposcopy and the evaluation of the endocervical canal. The latter is usually done by endocervical curettage, but due to its high rate of false negative results and important patient discomfort, efforts have been made to find alternative techniques [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

User perception of endocervical sampling: A randomized comparison of endocervical evaluation with the curette vs cytobrush

et al. 2017

View full text Add to dashboard Cite

ObjectivesTo evaluate whether the endocervical brush (ECB) is better accepted by patients and health care providers for endocervical evaluation when compared to the endocervical curette (ECC), without a decrease in the quality of sampling.MethodsTwo hundred patients with cervical dysplasia were randomized at the colposcopy clinic of the University Hospital of Geneva into two groups according to technique. Patients and physicians’ preference regarding the technique as well as the quality of samples were assessed. ECB samples were analyzed using both cytological (cell block) and histologic analysis, while ECC samples were analyzed using standard histologic analysis.ResultsOf the 200 patients, 89 were randomized to ECC, 101 to ECB and 10 were excluded due to incomplete information or cervical stenosis. Physicians preferred ECB against ECC, classifying it more frequently as an easy technique (94.1% vs.61.4%, p<0.001). Physicians more frequently evaluated the ECB as little or not uncomfortable for patients (28.7% vs.10.2%, p<0.001), though patients themselves didn’t express a preference for either technique. From a quality standpoint, the brush allowed for a better quality of samples, with a lower rate of inadequate samples (2.0% vs 14.3%, p = 0.002) and greater amount of material.ConclusionEndocervical sampling using ECB seems to be easier to perform and provides better quality samples. ECB can therefore be an acceptable alternative to ECC in standard practice.Trial registrationClinicalTrials.gov NCT01435590

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

User perception of endocervical sampling: A randomized comparison of endocervical evaluation with the curette vs cytobrush

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Endocervical brushing has better sensitivity than curettage with similar specificity, better tolerance, and fewer insufficient samples, although grading may be more difficult because stroma is rarely sampled with brushing. 15,16 Either is acceptable for endocervical sampling. In 2006, working groups assessing management of cytology reported as atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesions (LSIL) defined indications for endocervical sampling, guidance that should be valid for women with cytology results of Box 1.…”

Section: Guiding Principlesmentioning

confidence: 98%

2012 Updated Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors

Massad

Einstein

Huh

et al. 2013

Obstetrics &Amp; Gynecology

683

477

View full text Add to dashboard Cite

A group of 47 experts representing 23 professional societies, national and international health organizations, and federal agencies met in Bethesda, MD, September 14-15, 2012, to revise the 2006 American Society for Colposcopy and Cervical Pathology Consensus Guidelines. The group's goal was to provide revised evidence-based consensus guidelines for managing women with abnormal cervical cancer screening tests, cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS) following adoption of cervical cancer screening guidelines incorporating longer screening intervals and co-testing. In addition to literature review, data from almost 1.4 million women in the Kaiser Permanente Northern California Medical Care Plan provided evidence on risk after abnormal tests. Where data were available, guidelines prescribed similar management for women with similar risks for CIN 3, AIS, and cancer. Most prior guidelines were reaffirmed. Examples of updates include: Human papillomavirus-negative atypical squamous cells of undetermined significance results are followed with co-testing at 3 years before return to routine screening and are not sufficient for exiting women from screening at age 65 years; women aged 21-24 years need less invasive management, especially for minor abnormalities; postcolposcopy management strategies incorporate co-testing; endocervical sampling reported as CIN 1 should be managed as CIN 1; unsatisfactory cytology should be repeated in most circumstances, even when HPV results from co-testing are known, while most cases of negative cytology with absent or insufficient endocervical cells or transformation zone component can be managed without intensive follow-up.

show abstract

“…In the study thus identified, Goksedef et al 11 to present low prevalence. Moreover, those authors used a different brushing technique for sample collection: the material obtained through brushing was fixed in formaldehyde and processed for embedding in paraffin blocks, followed by histological analysis (rather than using conventional cytological analysis).…”

Section: Ninety-one Women Seen Between January 2012 and April 2017mentioning

confidence: 81%

Accuracy of endocervical cytological tests in diagnosing preinvasive lesions of the cervical canal in patients with type 3 transformation zone: a retrospective observational study

et al. 2020

View full text Add to dashboard Cite

BACKGROUND: Cervical cancer screening in Brazil is done using Pap smears. Women who are most likely to have a preinvasive lesion or cervical cancer are immediately referred for colposcopy. OBJECTIVE: The aim of this study was to evaluate the diagnostic performance of endocervical cytological tests in diagnosing preinvasive cervical lesions in women with initial high-grade squamous intraepithelial lesions (HSIL), or atypical squamous cells in which high-grade lesions could not be ruled out (ASC-H), or atypical glandular cells (AGC), and whose colposcopy did not show any abnormalities, with no fully visible transformation zone (types 2 and 3). DESIGN AND SETTING: Retrospective observational study conducted in Rio de Janeiro, Brazil. METHODS: Data from women who came to the cervical pathology outpatient clinic between January 2012 and April 2017 were analyzed. The results from endocervical cytological tests were compared with the final diagnosis, which was obtained through examination of a surgical specimen or, among women who did not undergo an excisional procedure, after cytological and colposcopic follow-up for two years. RESULTS: We included 78 women. The sensitivity of endocervical cytological tests was 72.7%; specificity 98.5%; positive and negative predictive values 88.9% and 95.6%, respectively; and positive and negative likelihood ratios 48.7 and 0.28. CONCLUSION: Endocervical cytological tests are simple, inexpensive and noninvasive, and form a reliable method for determining management among patients with HSIL, ASC-H and AGC cytological findings and negative colposcopic findings without visualization of the squamocolumnar junction.

show abstract

Diagnostic accuracy of two endocervical sampling method: randomized controlled trial

Cited by 17 publications

References 13 publications

User perception of endocervical sampling: A randomized comparison of endocervical evaluation with the curette vs cytobrush

User perception of endocervical sampling: A randomized comparison of endocervical evaluation with the curette vs cytobrush

2012 Updated Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors

Accuracy of endocervical cytological tests in diagnosing preinvasive lesions of the cervical canal in patients with type 3 transformation zone: a retrospective observational study

Contact Info

Product

Resources

About