Diagnostic and predictive value of speckle tracking echocardiography in cardiac sarcoidosis

Stefano, Cristina Di; Bruno, Giulia; Calle, Maria C. Arciniegas; Acharya, Gayatri; Fussner, Lynn M.; Ungprasert, Patompong; Cooper, Leslie T.; Blauwet, Lori A.; Ryu, Jay H.; Pellikka, Patricia A.; Porquera, Eva M. Carmona; Villarraga, Hector R.

doi:10.1186/s12872-019-01323-0

Cited by 42 publications

(40 citation statements)

References 40 publications

(37 reference statements)

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“…Several other groups have studied echo-derived strain using 2D or 3D speckle tracking echocardiography (STE) [ 25 – 30 ]. From the results, GLS has seemed to be the best marker.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular myocardial deformation assessment in asymptomatic patients with recently diagnosed sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis

Panovský

Doubková

Mojica-Pisciotti

et al. 2021

Orphanet J Rare Dis

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Background Sarcoidosis is a systemic granulomatous disease affecting different organs including the heart. Myocardial strain analysis could potentially detect the early stages of cardiac dysfunction in sarcoidosis patients. The present study aims to assess the use of cardiac magnetic resonance (CMR) strain analysis using feature tracking (FT) in the detection of early cardiac involvement in asymptomatic patients with sarcoidosis. Methods One hundred and thirteen CMR studies of patients with sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis without pre-existing known cardiovascular disease were included in the study and analysed using FT and compared to 22 age and gender-matched controls. Global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS) of the left ventricle (LV) were measured. Results The sarcoidosis patients did not significantly differ from the controls in basic demographic data and had normal global and regional systolic LV function—LV ejection fraction (EF) 66 ± 7% vs 65 ± 5% in the controls (p = NS). No statistically significant differences were found in all strain parameters between patients and controls: GLS (− 13.9 ± 3.1 vs. − 14.2 ± 2.5), GCS (− 23.4 ± 4.0 vs. − 22.2 ± 2.9) and GRS (53.4 ± 13.5 vs. 51.2 ± 13.6%) (p = NS). Conclusion Patients with sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis had normal myocardial deformation measured by CMR-FT derived global strain

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“…Several other groups have studied echo-derived strain using 2D or 3D speckle tracking echocardiography (STE) [ 25 – 30 ]. From the results, GLS has seemed to be the best marker.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular myocardial deformation assessment in asymptomatic patients with recently diagnosed sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis

Panovský

Doubková

Mojica-Pisciotti

et al. 2021

Orphanet J Rare Dis

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“…In all the echocardiographic parameters, this study showed that GLS is the best indicator to determine myocardial dysfunction due to PHP. Di Stefano et al 22 also reported a reduction in strain values in left ventricular GLS and right ventricular GLS in patients with cardiac sarcoidosis, Karadag et al 23 reported left ventricular GLS reduction in patients with systemic sclerosis, and Negishi et al 24 demonstrated that of the early subclinical changes in LV functions, GLS provided the most accurate prediction of chemotherapeutic cardiotoxicity in cancer treatment. In accordance with the findings of all the above‐mentioned studies, the current study results also showed a statistically significant early deterioration in GLS as an indicator for myocardial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The effect of successful parathyroid surgery on left ventricle function in patients with primary hyperparathyroidism evaluated with strain echocardiography

et al. 2020

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Background: Hyperparathyroidism (PHP) is the most common cause of hypercalcemia in outpatients. It is characterized by many cardiac complications including chronic cardiac arrhythmia, hypertrophy, and diastolic insufficiency. However, there are insufficient data about the cardiac systolic function in PHP. Data regarding the positive effects of surgical treatment on cardiac complications are limited and inadequate. The aim of this study was to evaluate the postoperative changes in the left ventricle functions of patients with PHP using strain echocardiography (STE) instead of traditional echocardiographic evaluation. Methods: This prospective study included 29 patients with PHP. Detailed echocardiographic evaluations were made including conventional and STE‚ ventricle function preoperatively and at 6 months after surgery. Then, preoperative and postoperative STE changes, global longitudinal (GLS) and circumferential strain (GCS), were compared. Patients with recurrent surgery, poor echogenicity, and comorbid conditions affecting STE were excluded.Results: No significant change was determined in ejection fraction in the period from preoperative to 6 months postoperative (P > .05). The GLS value increased from 18.53 ± 3.06 to 20.25 ± 3.89, to a statistically significant level (P = .004). The other echocardiographic parameters remained unchanged for the same patients. Conclusion:Despite normal 2D echocardiography data, it was determined that the GLS values deteriorated preoperatively and improved by the 6th postoperative month. The detection of early disorders in PHP that cannot be detected on 2D echocardiography, even in asymptomatic patients, may suggest a new treatment indication. For asymptomatic PHP patients, strain echocardiography may be more valuable than 2D echocardiographic evaluation to determine myocardial dysfunction. The recent literature is insufficient, and there is a need for further, more extensive studies with longer follow-up periods. K E Y W O R D Shyperparathyroidism, myocardial dysfunction, parathyroidectomy, strain echocardiography | 671 ATASEVER ET Al.

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“…The risk of potential malignant arrhythmias due to acute myocardits during competetive sport or in the presence of high responsibilities might justify the approaches to improve diagnostic tools like echocardiography which is widely available. A second diagnostic target of CS and LV rotation analysis by 2DSTE might be the early detection of cardiotoxic alterations in cancer patients during chemotherapy and of regional abnormalities of LV deformation due to granulomatous or storage diseases [43][44][45][46][47].…”

Section: The Rationale To Focus On Cs Rs and LV Rotation And Layer-smentioning

confidence: 99%

Analysis of left ventricular rotational deformation by 2D speckle tracking echocardiography: a feasibility study in athletes

Hofrichter

Hagendorff

Laufs

et al. 2021

Int J Cardiovasc Imaging

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Abstract2D speckle tracking echocardiography (2DSTE) is established to analyse left ventricular (LV) longitudinal function. The analysis of LV rotational deformation is challenging and requires standardization of image acquisition as well as postprocessing analysis. The aim of this study was to test the feasibility to analyse LV rotational deformation using 2DSTE by introducing a novel algorithm for the detection of artefacts. The study was performed in 20 healthy subjects serving as a control group and in 53 competitive sportsmen. Circumferential, radial strain (CS, RS) and LV rotation were analysed by 2DSTE in parasternal short axis views. The stepwise algorithm to exclude potential artefacts starts with the visual estimation of the image quality with respect to complete visualization of all myocardial segments during the entire cardiac cycle followed by the exclusion of data sets in participants with conduction abnormalities. The next step is the optimization of tracking areas and a cross-check of implausible strain waveforms in multiple acquired comparable cineloops. The last step is the exclusion of strain curves with persisting implausible waveforms if standardization failures and incorrect LV wall tracking are fixed. Plausible physiological strain curves were observed in 89% (n = 65/73) of all subjects. In controls all implausible waveforms could be verified as artefacts. The algorithm was applied in 53 professional athletes to test and confirm its feasibility. Abnormal CS waveforms were documented in 25 athletes, verified as artefacts due to tracking failures in 22 athletes and due to incorrect image acquisition in 3 athletes. CS artefacts were mostly located in the basal posterior and lateral LV segments. (endocardial: 6%, n = 4/70; p < 0.05) and basal posterior (endocardial: 8%, n = 5/70; p < 0.05) segments were highly susceptible to artefacts. 2DSTE of parasternal short axis views to analyse circumferential and radial deformation as well as LV rotation is feasible in athletes. The proposed algorithm helps to avoid artefacts and might contribute to standardization of this technique. 2DSTE might provide an interesting diagnostic tool for the detection of viral myocarditis, e.g. in athletes.

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Diagnostic and predictive value of speckle tracking echocardiography in cardiac sarcoidosis

Cited by 42 publications

References 40 publications

Left ventricular myocardial deformation assessment in asymptomatic patients with recently diagnosed sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis

Left ventricular myocardial deformation assessment in asymptomatic patients with recently diagnosed sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis

The effect of successful parathyroid surgery on left ventricle function in patients with primary hyperparathyroidism evaluated with strain echocardiography

Analysis of left ventricular rotational deformation by 2D speckle tracking echocardiography: a feasibility study in athletes

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