Diagnostic and Predictive Values of Circulating Extracellular Vesicle-Carried microRNAs in Ischemic Heart Disease Patients With Type 2 Diabetes Mellitus

Zhang, Li; Zhang, Jianchao; Qin, Zhen; Liu, Na; Zhang, Zenglei; Lu, Yongzheng; Xu, Yanyan; Zhang, Jinying; Tang, Junnan

doi:10.3389/fcvm.2022.813310

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…A small study investigated the expression of miR-210 in plasma-derived extracellular vesicles in T2DM patients with ischemic heart disease. They reported a downregulation of miR-210 compared to healthy controls and concluded that plasma-derived extracellular vesicles and their cargo could be a potential biomarker for ischemic heart disease in T2DM [ 86 ]. Zhu and Leung concluded that miR-221 is significantly upregulated in the serum of T2DM patients and is one of the most important biomarkers for T2DM [ 71 ].…”

Section: The Role Of Micrornas In Atherosclerosis Psoriasis T2dm and Ramentioning

confidence: 99%

A Review of MicroRNAs and lncRNAs in Atherosclerosis as Well as Some Major Inflammatory Conditions Affecting Atherosclerosis

Letonja,

Petrovič

2024

Biomedicines

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It is generally accepted that atherosclerosis is a chronic inflammatory disease. The link between atherosclerosis and other inflammatory diseases such as psoriasis, type 2 diabetes mellitus (T2DM), and rheumatoid arthritis (RA) via metabolic, inflammatory, and immunoregulatory pathways is well established. The aim of our review was to summarize the associations between selected microRNAs (miRs) and long non-coding RNAs (lncRNAs) and atherosclerosis, psoriasis, T2DM, and RA. We reviewed the role of miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, let-7, lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, and lncRNA-XIST in atherosclerosis and psoriasis, T2DM, and RA. Extracellular vesicles (EVs) are a method of intracellular signal transduction. Their function depends on surface expression, cargo, and the cell from which they originate. The majority of the studies that investigated lncRNAs and some miRs had relatively small sample sizes, which limits the generalizability of their findings and indicates the need for more research. Based on the studies reviewed, miR-146a, miR-155, miR-145, miR-200, miR-133, and lncRNA-H19 are the most promising potential biomarkers and, possibly, therapeutic targets for atherosclerosis as well as T2DM, RA, and psoriasis.

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Section: The Role Of Micrornas In Atherosclerosis Psoriasis T2dm and Ramentioning

confidence: 99%

A Review of MicroRNAs and lncRNAs in Atherosclerosis as Well as Some Major Inflammatory Conditions Affecting Atherosclerosis

Letonja,

Petrovič

2024

Biomedicines

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“…A small study investigated the expression of miR-210 in plasma-derived extracellular vesicles in T2DM patients with ischemic heart disease. They reported a downregulation of miR-210 compared to healthy controls and concluded that plasma-derived extracellular vesicles and their cargo could be a potential biomarker for ischemic heart disease in T2DM [77]. Zhu and Leung concluded that miR-221 is significantly upregulated in the serum of T2DM patients and is one of the most important biomarkers for T2DM [62].…”

Section: Mir-210mentioning

confidence: 99%

Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions

Letonja,

Petrovič

2023

Preprint

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It is generally accepted that atherosclerosis is a chronic inflammatory disease. The link between atherosclerosis and other inflammatory diseases such as psoriasis, type 2 diabetes mellitus (T2DM), and rheumatoid arthritis (RA) via metabolic, inflammatory, and immunoregulatory pathways is well established. The aim of our review was to summarize the associations between selected microRNAs (miRs) and long non-coding RNAs (lncRNAs) and atherosclerosis, psoriasis, T2DM, and RA. MicroRNAs are short noncoding RNA molecules involved in cell signaling, intracellular communication, and gene expression. We reviewed the role of miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, and let-7 in atherosclerosis, psoriasis, T2DM, and RA. LncRNAs are RNA transcripts longer than 200 nucleotides that are involved in cellular processes such as apoptosis, metabolism, inflammation, cell differentiation, and proliferation. We evaluated the role of lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, and lncRNA-XIST in atherosclerosis and psoriasis, T2DM, and RA. Extracellular vesicles (EVs) are a method of intracellular signal transduction. Their function depends on surface expression, cargo, and the cell from which they originate.

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“…Another inflammation-associated miR that downregulates the MR is miR-155-5p. Reduced blood levels of miR-155-5p were not only found in patients with coronary artery disease with intermittent hypoxic states for cardiomyocytes, but also in patients with diabetes mellitus and ischemic heart disease [ 179 , 180 , 181 ]. Additionally, age was inversely correlated to miR-155-5p blood levels [ 179 ].…”

Section: Mr Signaling and Micromilieumentioning

confidence: 99%

Importance of Micromilieu for Pathophysiologic Mineralocorticoid Receptor Activity—When the Mineralocorticoid Receptor Resides in the Wrong Neighborhood

Griesler

Schuelke

Uhlig

et al. 2022

IJMS

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The mineralocorticoid receptor (MR) is a member of the steroid receptor family and acts as a ligand-dependent transcription factor. In addition to its classical effects on water and electrolyte balance, its involvement in the pathogenesis of cardiovascular and renal diseases has been the subject of research for several years. The molecular basis of the latter has not been fully elucidated, but an isolated increase in the concentration of the MR ligand aldosterone or MR expression does not suffice to explain long-term pathologic actions of the receptor. Several studies suggest that MR activity and signal transduction are modulated by the surrounding microenvironment, which therefore plays an important role in MR pathophysiological effects. Local changes in micromilieu, including hypoxia, ischemia/reperfusion, inflammation, radical stress, and aberrant salt or glucose concentrations affect MR activation and therefore may influence the probability of unphysiological MR actions. The surrounding micromilieu may modulate genomic MR activity either by causing changes in MR expression or MR activity; for example, by inducing posttranslational modifications of the MR or novel interaction with coregulators, DNA-binding sites, or non-classical pathways. This should be considered when developing treatment options and strategies for prevention of MR-associated diseases.

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Diagnostic and Predictive Values of Circulating Extracellular Vesicle-Carried microRNAs in Ischemic Heart Disease Patients With Type 2 Diabetes Mellitus

Cited by 8 publications

References 41 publications

A Review of MicroRNAs and lncRNAs in Atherosclerosis as Well as Some Major Inflammatory Conditions Affecting Atherosclerosis

A Review of MicroRNAs and lncRNAs in Atherosclerosis as Well as Some Major Inflammatory Conditions Affecting Atherosclerosis

Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions

Importance of Micromilieu for Pathophysiologic Mineralocorticoid Receptor Activity—When the Mineralocorticoid Receptor Resides in the Wrong Neighborhood

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