Diagnostic and prognostic role of serum miR‐20b, miR‐17‐3p, HOTAIR, and MALAT1 in diabetic retinopathy

Shaker, Olfat G.; Abdelaleem, Omayma O; Mahmoud, Rania H.; Abdelghaffar, Noha K.; Ahmed, Tarek I.; Said, Omar M; Zaki, Othman M.

doi:10.1002/iub.1970

Cited by 79 publications

(70 citation statements)

References 44 publications

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“…Among the findings in this study, one of them indicated that miR‐20b‐3p was poorly expressed, while TXNIP was highly expressed in retinal tissues of DR rats. Similarly, Shi et al have demonstrated that the expression level of miR‐20b‐3p reduced in both urine of patients and kidney tissues from animal models with hyperoxaluria‐induced calcium oxalate deposition, and it has also been clarified that miR‐20b was decreased in serum of patients with proliferative and non‐proliferative DR in contrast to the healthy controls . The overexpression of TXNIP has also been unraveled in various human diseases.…”

Section: Discussionmentioning

confidence: 90%

Elevated microRNA‐20b‐3p and reduced thioredoxin‐interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes

Wang

et al. 2020

IUBMB Life

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Over the years, microRNA‐20b‐3p (miR‐20b‐3p) has been found to play an essential role in human diseases; we aimed to investigate the effect of miR‐20b‐3p on the progression of diabetic retinopathy (DR). The DR rat models were established by streptozotocin injection and treated with miR‐20b‐3p mimics, silenced, or overexpressed thioredoxin‐interacting protein (TXNIP). Afterward, the expression of miR‐20b‐3p and TXNIP, visual function, inflammatory factors, microvascular injury, vascular permeability, cell apoptosis, and angiogenesis in rats' retinal tissues were assessed. The target relation between miR‐20b‐3p and TXNIP was confirmed by dual luciferase reporter gene assay. MiR‐20b‐3p was poorly expressed while TXNIP was highly expressed in DR rats' retinal tissues. Elevated miR‐20b‐3p and inhibited TXNIP promoted the visual function, and restricted the inflammatory reaction, microvascular injury, vascular permeability, cell apoptosis, and angiogenesis in DR rats, thereby decelerating the development of DR. Furthermore, TXNIP was targeted by miR‐20b‐3p. We have found in this study that elevated miR‐20b‐3p could repress the levels of inflammatory factors by inhibiting TXNIP, thus attenuating the pathology of retina in DR rats, which provided new candidates for DR treatment.

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Section: Discussionmentioning

confidence: 90%

Elevated microRNA‐20b‐3p and reduced thioredoxin‐interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes

Wang

et al. 2020

IUBMB Life

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“…It is speculated that miRNA regulates one third of the human genes [4]. Meanwhile, some breakthrough study in 2016 [5] demonstrated that miRNAs are also extracellular, being present in a cell-free circulating form in the serum, plasma, saliva, tears, aqueous and vitreous humor, and urine [6,7], which could be called circulating miRNAs.…”

Section: Circulating Mirnas As Biomakers In Drmentioning

confidence: 99%

MicroRNAs: Potential Targets in Diabetic Retinopathy

Wang

et al. 2020

Horm Metab Res

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Diabetic retinopathy (DR), a serious microvascular complication of diabetes, is a leading cause of blindness in adults. The pathogenesis of DR involves a variety of tissues and complex mechanisms, such as inflammation, oxidative stress, optic neurodegeneration, and autophagy. Nowadays, microRNAs (miRNAs), a novel group of non-coding small RNAs, have been extensively studied and recognized to play a key role in the pathogenesis of DR through aforementioned pathways. Furthermore, some miRNAs have been proposed as biomarkers that may be utilized to screen for DR. Also, miRNAs are a new therapy for DR. In this review, we summarize several miRNAs and, their roles in the pathogenesis of DR. miRNAs, as potential pharmacological targets for the diabetic retinopathy, may provide new insights for the treatment of DR.

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“…While a significant decrease in serum miR-20b was found in diabetic patients compared to healthy subjects, a decrease in serum miR-20b and miR-17-3p was found in NPDR and PDR groups when compared with healthy subjects. A combined analysis of these noncoding RNAs with two regulators of retinal endothelial dysfunction, Homebox antisense intergenic RNA (HOTAIR) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), was able to discriminate diabetic patients without retinopathy from healthy controls and NPDR and PDR from diabetic patients without retinopathy, suggesting that miR-20b and miR-17-3p may be used as noninvasive biomarkers for screening of DR and the early diagnosis of PDR [115].…”

Section: Mirna In Dr: Role In Oxidative Stress and Inflammatory Signamentioning

confidence: 99%

Extracellular Vesicles and MicroRNA: Putative Role in Diagnosis and Treatment of Diabetic Retinopathy

et al. 2020

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Diabetic retinopathy (DR) is a complex, progressive, and heterogenous retinal degenerative disease associated with diabetes duration. It is characterized by glial, neural, and microvascular dysfunction, being the blood-retinal barrier (BRB) breakdown a hallmark of the early stages. In advanced stages, there is formation of new blood vessels, which are fragile and prone to leaking. This disease, if left untreated, may result in severe vision loss and eventually legal blindness. Although there are some available treatment options for DR, most of them are targeted to the advanced stages of the disease, have some adverse effects, and many patients do not adequately respond to the treatment, which demands further research. Oxidative stress and low-grade inflammation are closely associated processes that play a critical role in the development of DR. Retinal cells communicate with each other or with another one, using cell junctions, adhesion contacts, and secreted soluble factors that can act in neighboring or long-distance cells. Another mechanism of cell communication is via secreted extracellular vesicles (EVs), through exchange of material. Here, we review the current knowledge on deregulation of cell-to-cell communication through EVs, discussing the changes in miRNA expression profiling in body fluids and their role in the development of DR. Thereafter, current and promising therapeutic agents for preventing the progression of DR will be discussed.

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Diagnostic and prognostic role of serum miR‐20b, miR‐17‐3p, HOTAIR, and MALAT1 in diabetic retinopathy

Cited by 79 publications

References 44 publications

Elevated microRNA‐20b‐3p and reduced thioredoxin‐interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes

Elevated microRNA‐20b‐3p and reduced thioredoxin‐interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes

MicroRNAs: Potential Targets in Diabetic Retinopathy

Extracellular Vesicles and MicroRNA: Putative Role in Diagnosis and Treatment of Diabetic Retinopathy

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