2019
DOI: 10.1016/j.jpedsurg.2018.12.002
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Diagnostic and prognostic utility of SF1, IGF2 and p57 immunoexpression in pediatric adrenal cortical tumors

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Cited by 11 publications
(12 citation statements)
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“…In our experience, one of the three patients who experienced metastatic disease obtained complete remission with platinum-based chemotherapy and mitotane. Overexpression of the IGF2 and IGF1R genes was described in ACT also in the pediatric setting ( 41 ), but trials testing the utility of insulin like growth factor receptor 1 inhibitors (e.g., linsitinib) have failed to provide advantage for adulthood ACC treatment ( 42 ).…”
Section: Discussionmentioning
confidence: 99%
“…In our experience, one of the three patients who experienced metastatic disease obtained complete remission with platinum-based chemotherapy and mitotane. Overexpression of the IGF2 and IGF1R genes was described in ACT also in the pediatric setting ( 41 ), but trials testing the utility of insulin like growth factor receptor 1 inhibitors (e.g., linsitinib) have failed to provide advantage for adulthood ACC treatment ( 42 ).…”
Section: Discussionmentioning
confidence: 99%
“…As of this, a separate scoring system proposed by Wieneke et al combine nine macroscropic and microscopic features of pediatric adrenal cortical neoplasms associated to clinically malignant cases. This model has since been reproduced by other groups and could potentially also benefit from the inclusion of P53, IGF2, and Ki-67 immunostainings [146][147][148]. ACCs are regularly uniformly positive for synaptophysin and SF1 and usually exhibit some grade of calretinin and melan A expression.…”
Section: Histological Evaluation Of Malignant Behaviormentioning
confidence: 97%
“…However, reliably distinguishing ACC from ACA is difficult on FNAC and CB in absence of capsular and vascular invasion. These become even more difficult in paediatric patients where cytological features alone are not an adequate guide in favour of malignancy 14‐17 …”
Section: Discussionmentioning
confidence: 99%