Diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma

Abstract

This study aimed to explore the value of combined detection of serum thyroglobulin (Tg), interferon - γ (IFN - γ) and thyroglobulin antibody (TgAb) in the diagnosis and prognosis of thyroid adenoma (TA). For this purpose, 100 patients with TA in our hospital from January 2017 to December 2020 were selected as the observation group, and they were divided into good prognosis group (83 cases) and poor prognosis group (17 cases) according to the surgical treatment; another 50 healthy people who received physical examination in our hospital. The levels of serum Tg, IFN - γ and TgAb in each group were detected and compared; the diagnostic and prognostic value of combined detection of serum Tg, IFN - γ and TgAb in thyroid adenoma were analyzed. Results showed that compared with the control group, the levels of Tg and TgAb in the observation group were significantly increased, and the levels of IFN - γ were significantly decreased (P < 0.05); compared with the poor prognosis group, the levels of Tg and TgAb in the good prognosis group were significantly decreased, and the levels of IFN - γ were significantly increased (P < 0.05); The area under curve (AUC) of the combined detection of serum Tg, IFN-γ and TgAb for TA diagnosis and prognosis assessment was significantly higher than the value detected by a single indicator. In general, the combined detection of serum Tg, IFN - γ and TgAb has high diagnostic and prognostic value for TA, and has high clinical reference value.

Evaluation of the value of combined thyroid function-related indexes in the prognosis prediction of patients with differentiated thyroid cancer

“…[23] Elevated Tg-Ab levels may indicate heightened immunoreactivity, possibly linked to an increased risk of recurrence or metastasis in DTC patients. [24] Notably, the present study found no significant difference in the levels of FT3 and FT4 between the good and poor prognosis groups, which may be related to several factors. First, thyroid hormones are precisely regulated by the hypothalamicpituitary-thyroid axis, and the negative feedback mechanism helps to maintain FT3 and FT4 at relatively stable levels.…”

“…[23] Elevated Tg-Ab levels may indicate heightened immunoreactivity, possibly linked to an increased risk of recurrence or metastasis in DTC patients. [24]…”

GLP-1 receptor agonist liraglutide inhibits the proliferation and migration of thyroid cancer cells

“…Starting with the approval of GLP-1RAS, there have been many discussions about the potential safety of GLP-1RAs for the treatment of diabetes, since it may induce thyroid disease. Although GLP-1RAs can effectively control blood sugar and reduce body weight, based on research on rodents during the drug development stage, people have raised concerns about the occurrence of medullary thyroid carcinoma (MTC) (10)(11)(12)(13). Therefore, in the United States, labels of GLP-1RAs product contain a black box warning.…”

“…In rats, the activation of GLP-1R can increase the amount of cyclic adenosine monophosphate in C-cells, which leads to the secretion of intracellular calcitonin, which promotes the proliferation and carcinogenesis of C-cells (16,17). Although calcitonin is a critical biomarker for MTC existence (13,18,19), it was not found that GLP-1RAs mediates elevation of calcitonin in non-human primates (17,18) or patients with type 2 diabetes (20,21). In view of these findings, we need to comprehensively and scientifically balance the benefits and possible risks of GLP-1RAs treatment in diabetes.…”