Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients

Abstract

Background and Objectives: Omentin-1, also known as intelectin-1, is a novel adipokine with anti-inflammatory activities implicated in inflammatory diseases and sepsis. We aimed to explore serum omentin-1 and its kinetics in critically ill patients early in sepsis and its association with severity and prognosis. Materials and Methods: Serum omentin-1 was determined in 102 critically ill patients with sepsis during the first 48 h from sepsis onset and 1 week later, and in 102 age- and gender-matched healthy controls. The outcome of sepsis at 28 days after enrollment was recorded. Results: Serum omentin-1 at enrollment was significantly higher in patients compared to controls (763.3 ± 249.3 vs. 451.7 ± 122.3 μg/L, p < 0.001) and it further increased 1 week after (950.6 ± 215.5 vs. 763.3 ± 249.3 μg/L, p < 0.001). Patients with septic shock (n = 42) had higher omentin-1 compared to those with sepsis (n = 60) at enrollment (877.9 ± 241.2 vs. 683.1 ± 223.7 μg/L, p < 0.001) and 1 week after (1020.4 ± 224.7 vs. 901.7 ± 196.3 μg/L, p = 0.007). Furthermore, nonsurvivors (n = 30) had higher omentin-1 at sepsis onset (952.1 ± 248.2 vs. 684.6 ± 204.7 μg/L, p < 0.001) and 1 week after (1051.8 ± 242 vs. 908.4 ± 189.8 μg/L, p < 0.01). Patients with sepsis and survivors presented higher kinetics than those with septic shock and nonsurvivors (Δ(omentin-1)% 39.8 ± 35.9% vs. 20.2 ± 23.3%, p = 0.01, and 39.4 ± 34.3% vs. 13.3 ± 18.1%, p < 0.001, respectively). Higher omentin-1 at sepsis onset and 1 week after was an independent predictor of 28-day mortality (HR 2.26, 95% C.I. 1.21–4.19, p = 0.01 and HR: 2.15, 95% C.I. 1.43–3.22, p < 0.001, respectively). Finally, omentin-1 was significantly correlated with the severity scores, the white blood cells, coagulation biomarkers, and CRP, but not procalcitonin and other inflammatory biomarkers. Conclusions: Serum omentin-1 is increased in sepsis, while higher levels and lower kinetics during the first week of sepsis are associated with the severity and 28-day mortality of sepsis. Omentin-1 may be a promising biomarker of sepsis. However, more studies are needed to explore its role in sepsis.

Alterations of the Adipo–Myokine Irisin in Sepsis and Septic Shock: Diagnostic and Prognostic Implications

“…In addition to irisin, the adipose tissue and the liver secrete many biologically active proteins (adipokines and hepatokines) that exert immunomodulatory actions (regulatory, pro-inflammatory, and anti-inflammatory) and exhibit alterations during sepsis [ 51 , 52 ]. In particular, adiponectin, leptin, resistin, visfatin, chemerin, and omentin increase at sepsis onset, and their kinetics in the early phase of sepsis are associated with sepsis mortality [ 53 , 54 , 55 , 56 , 57 ]. These findings support the hypothesis that the adipose tissue, the liver, and the muscles are active immunomodulators during sepsis.…”

Human Intelectin-1 (hITL-1) as Modulator of Metabolic Syndrome (MetS): An In Silico Study

“…Interesting, intelectin 1 has been known to inhibit TNF-alpha, MyD88, TLR4, COX 2, VCAM 1, IL 6, and NF kappa B. [ 11 ] Thus the above-mentioned background prompted us to carry out the current study, where eight proteins (like hTNF-alpha, hMyD88, hTLR4, hCOX 2, hVCAM 1, hNF kappa B, leptin, and hIL 6) were chosen as interested proteins (ligands) and study the docking potential of these eight proteins (ligands) with target protein hITL 1 (receptor).…”

“…[ 8 ] The clinical investigations have observed that circulating intelectin 1 levels are shown lower in cancer, cardiovascular diseases, chronic inflammation, metabolic syndrome (MetS), obesity, and type 2 diabetes. [ 9 10 11 12 ] Moreover, intelectin 1 has been demonstrated to inhibit the NF-kappa B signaling pathway as well as the TNF-alpha-induced expression of adhesion molecules [like vascular cell adhesion molecule 1 (VCAM 1) and intercellular adhesion molecule 1 (ICAM 1)]. Thus, these adhesion molecules (VCAM 1 and ICAM 1) suppress the pro-inflammatory activity of TNF.…”

25-hydroxyvitamin D and parathyroid hormone in new onset sepsis: A prospective study in critically ill patients

“…We prospectively enrolled consecutive critically ill cases hospitalized in the Intensive Care Unit (ICU) of a tertiary academic hospital with new onset sepsis, fulfilling the SEPSIS-3 diagnostic criteria of sepsis or septic shock [ 23 ]. The protocol of the study has been published in the past [ [24] , [25] , [26] , [27] ]. Patients were enrolled within 48 h from sepsis diagnosis.…”