Diagnostic and prognostic value of circulating miR-21 for cancer: A systematic review and meta-analysis

Wang, Yang; Gao, Xiujuan; Wei, Feng; Zhang, Xinwei; Yu, Jinpu; Zhao, Hua; Sun, Qian; Fan, Yan; Yan, Chunhong; Li, Hui; Ren, Xiubao

doi:10.1016/j.gene.2013.09.038

Cited by 134 publications

(110 citation statements)

References 60 publications

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“…Furthermore, circulating miR-21 also shows many advantages compared with histopathological examination, most notably that its detection does not require an invasive or harmful procedure. Wang et al (2014c) also demonstrated that serum miR-21 was a significant independent factor for HCC recurrence, and this measure was also reported to be more sensitive than AFP for the detection of HCC. This observation suggests that serum miRNAs, such as miR-21, might be useful for the prediction of HCC risk and the early detection of HCC (Wang et al, 2014a).…”

Section: Discussionmentioning

confidence: 84%

“…miRNAs have been proposed to represent ideal biomarker candidates because of their resistance to endogenous RNase resistance and high stability under different storage conditions (Schwarzenbach et al, 2014) and in the peripheral blood (Zhu et al, 2012;Wang et al, 2014c). Abnormal miRNA expression is closely associated with HCC (Tomimaru et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

Yan

Liu

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The diagnostic and prognostic value of miR-21 has been examined for hepatocellular carcinoma (HCC), with inconsistent results. Present meta-analysis summarized the diagnostic accuracy and the predictive role for survival of miR-21 in patients with HCC. All eligible studies were searched using PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases up to October 2014. For the diagnostic meta-analysis, the indices of miR-21 in the diagnosis of HCC were pooled using bivariate random-effect approach models. For the prognostic meta-analysis, data were synthesized with a random effect model, and the hazard ratio (HR) or odd ratio (OR) with its 95% confidence interval (95%CI) was used as the effect size estimate. Ten studies dealing with HCC were included. The overall pooled results for sensitivity, specificity, and the area under the curve (AUC) for the diagnostic meta-analysis (five studies) were 74. The combined data for the prognostic meta-analysis (seven studies) suggested that miR-21 overexpression in HCC correlated with poor overall survival [HR = 1.19 (95%CI = 0.44-1.94)], and higher miR-21 expression was associated with tumor, node, metastases (TNM) stage [OR = 0.34 (95%CI = 0.13-0.91)]. We concluded that miR-21 might be complementary to alpha fetal protein in HCC diagnosis, and might serve as an attractive estimator of HCC. We also demonstrated that miR-21 overexpression was associated with HCC TNM stage and with poor survival. As our study was limited, additional prospective studies are needed to validate these results.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

Yan

Liu

et al. 2015

Genet. Mol. Res.

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“…And there have been numerous meta-analyses about miR-21 for cancer detection. In the meta-analysis of Wang et al, the pooled sensitivity and specificity of miR-21 in cancer diagnosis were 75.7% (95%CI: 67.5%-82.65%) and 79.3% (95%CI: 74.2%-83.5%), respectively (Wang et al, 2014). Chan et al have also demonstrated that miR-21 was over-expressed in tissues of 92% patients with gastric cancer (Chan et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Detection of MicroRNA-21 Expression as a Potential Screening Biomarker for Colorectal Cancer: a Meta-analysis

Jiang

Zhang²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is a major cause of cancer-related death and cancer-related incidence worldwide. The potential of microRNA-21 (miR-21) as a biomarker for CRC detection has been studied in several studies. However, the results were inconsistent. Therefore, we conducted the present meta-analysis to systematically assess the diagnostic value of miR-21 for CRC. Materials and Methods: Using a random-effect model, the pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated to evaluate the diagnostic performance of miR-21 for CRC. A summary receiver operating characteristic (SROC) curve and an area under the curve (AUC) were also generated to assess the diagnosis accuracy of miR-21 for CRC. Q test and I2 statistics were used to assess betweenstudy heterogeneity. Subgroup analyses further suggested that blood-based studies showed a better diagnostic accuracy compared with feces-based studies, indicating that blood may be a better matrix for miR-21 assay and CRC detection. Conclusions: Our findings suggest that miR-21 has a potential diagnostic value for CRC with a moderate level of overall diagnostic accuracy. Hence, it could be used as auxiliary means for the initial screening of CRC and avoid unnecessary colonoscopy, which is an invasive and expensive procedure.

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“…The same holds true for miR-155 that is not only over-expressed in different malignant tumors but also plays a role in a variety of physiological and pathophysiological conditions such as immunity, inflammation and cardiovascular diseases (more examples of aberrantly regulated cfmiRNAs in more than one organ are summarized in Table 3) [111]. In a recently published meta-analysis, it was demonstrated that cfmiR-21 is not suitable as a diagnostic marker for cancer [124]. This statement does not come as a surprise given the facts that in most studies cancer patients (i) were compared Overexpressed [97] Overexpressed in multiple myeloma [114] 21 Overexpressed in several papers, see Table 2 Overexpressed in: colorectal cancer [115] pancreatic cancer [116] Overexpressed in: hepatitis C patients with/ without hepatocellular Tong squamous cell carcinoma [117] Carcinoma [119] Osteosarcoma [118] Students performing acute exhaustive excercise [120] Gastric cancer [113] 155 Overexpressed in several papers, see Table 2 Overexpressed in: pancreatic cancer [116] Breast cancer [121] 372…”

Section: Mirnamentioning

confidence: 95%

Extracellular Nucleic Acids and Cancer

Fleischhacker¹,

Schmidt²

2014

Advances in Predictive, Preventive and Personalised Medicine

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Since the clear proof of the presence of tumor-associated genetic alterations in extracellular nucleic acids almost 20 years ago this field gained has attracted much interest. According to our current knowledge it seems as if all tumor-associated alterations found in tumor cells are also found in the extracellular environment. The isolation of extracellular nucleic acids from tumor patients and its genetic characterization with very sensitive and highly specific methods led to the concept of "liquid biopsy". This means that for follow-up analysis of tumor patients, the physicians no longer depend exclusively on a single examination of tissue biopsies (usually at the time of diagnosis) but are able by longitudinally analyzing the extracellular nucleic acids to follow the reaction of a tumor to e.g. a given therapy, the development of resistance mechanisms. In this chapter we will discuss the detection and characterization of different genetic (e.g. mutation analysis and structural variations as seen in microsatellites), epigenetic (e.g. hypermethylation of selected sequences) and regulatory alterations (as in different miRNA expression patterns found in tumor patients). We will also touch on some confounding factors that have to be taken into consideration as well as the functional and biological aspects of extracellular nucleic acids.

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Diagnostic and prognostic value of circulating miR-21 for cancer: A systematic review and meta-analysis

Cited by 134 publications

References 60 publications

Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

Detection of MicroRNA-21 Expression as a Potential Screening Biomarker for Colorectal Cancer: a Meta-analysis

Extracellular Nucleic Acids and Cancer

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