Diagnostic and Prognostic Value of Lung Ultrasound B-Lines in Acute Heart Failure With Concomitant Pneumonia

Mazzola, Matteo; Pugliese, Nicola Riccardo; Zavagli, Martina; Biase, Nicolò De; Bandini, Giulia; Barbarisi, Giorgia; D’Angelo, Gennaro; Sollazzo, Michela; Piazzai, Chiara; David, Simon; Masi, Stefano; Moggi-Pignone, Alberto; Gargani, Luna

doi:10.3389/fcvm.2021.693912

Cited by 6 publications

(7 citation statements)

References 42 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As one of the important components of immunoglobulins, IgM has the same characteristics as CRP to exclude the influences of individual differences, shows a high sensitivity and is often used for clinical differential diagnosis [28,29]. Other clinical studies have shown that ABC count is also an important indicator commonly used to determine bacterial infection in patients, but it is susceptible to a number of factors that can lead to a lower percentage of positivity compared to indicators such as CRP and IgM [30,31]. However, this phenomenon was not reflected in the data from this study, which may be related to the small sample size of this study and the exclusion of differences in age, gender and other factors [32,33].…”

Section: Discussionmentioning

confidence: 99%

Clinical application of C-reactive protein, leukocyte and immunoglobulin in the diagnosis and treatment of infantile pneumonia at acute stage

2023

View full text Add to dashboard Cite

This study aims to explore the clinical significance of C-reactive protein, leukocyte and immunoglobulin in the diagnosis and treatment of infantile pneumonia at acute stage. From January to December 2018, a total of 124 children with pneumonia and healthy children admitted to our hospital were selected as study objects. Among them, 62 children diagnosed with bacterial pneumonia were categorized as the study group, and 62 healthy children who came for physical examination were classified as the control group. The levels of C-reactive protein (CRP), white blood cell (WBC) and immunoglobulin (IgA, IgM and IgG) were observed and compared in the two groups. In this study, higher levels of CRP, IgM, IgG and WBC, along with lower level of IgA were observed in the study group as compared with that in the control group. In the study group, the levels of CRP, IgM, IgG and WBC were lower, but the IgA level was higher in children with mild pneumonia than those with severe pneumonia. After treatment, the levels of CRP, IgM, IgG and WBC were decreased but IgA level was increased after treatment compared with before treatment. In particular, the levels of CRP, WBC, IgA, IgM and IgG in the study group after treatment were restored to comparable levels compared with the control group. Therefore, C-reactive protein, leukocyte and immunoglobulin can be used to determine the diagnosis, condition and outcome of children with pneumonia in the acute stage. This study can provide guidance for clinical diagnosis and treatment of infantile pneumonia based

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical application of C-reactive protein, leukocyte and immunoglobulin in the diagnosis and treatment of infantile pneumonia at acute stage

2023

View full text Add to dashboard Cite

show abstract

“…For instance, Russel et al [31] reported a coefficient of 0,74 after a trial of approximately 11 exams and two hours of theoretical class. Miglioranza et al [25] reported a coefficient of 0.98 (95% IC : 0.98-0.99 ; p < 0.0001) in a set of 20 consecutive patients, M. Mazzola et al [32] found a coefficient of 0.98 (p < 0.0001) in 50 LUS videos evaluated by an expert reader.…”

Section: Strenghsmentioning

confidence: 97%

Interest of Lung Ultrasound in the Management of Acute Heart Failure in Post-emergency Service

Bel Alonso,

Grember,

Cheval

et al. 2024

Preprint

View full text Add to dashboard Cite

(1) Background: LUS has emerged as a simple, rapid and non-invasive method for the dynamic assessment of pulmonary congestion, a major prognostic factor and a therapeutic target in AHF. (2) Methods: In the single-center prospective observational study, 42 patients hospitalized for AHF in the post-emergency polyvalent medicine department of CHU Grenoble were successively included between May 2021 and July 2022. Clinical examination, LUS and electrolyte panel results were collected daily. Vital status was assessed 30 days after the last LUS. The primary endpoint was the evolution of the number of B-lines according to the dose of diuretic administered ; (3) Results: We performed 188 LUS. Our patients were elderly (85.8 [SD 8.1]) and comorbid. The median number of B-lines decreased from 17 at admission to 7 in the middle of the hospital stay, then stagnated until discharge. Simultaneously, the median dose of diuretics, initially stable at a maximum of 40 mg/d IV, decreased to 20mg/d IV by the end of hospital stay. Patients with CKD had a higher mean number of B-lines at entry (24.2 [SD 11.6]) compared to those without CKD (8.2 [SD 8.8]). However, the evolution of B-lines number was independent of creatinine levels. 30-day all-causes mortality was significantly related to the number of B-lines at discharge (15.2 [SD 10.1] in deceased patients versus 3.9 [SD 5.4] in living patients, p

show abstract

“…Then, the univariate and multivariate logistic regression, least absolute shrinkage selector operator (LASSO) regression analysis, nomogram, receiver operating characteristic (ROC) curve plot, and internal validation were performed to construct the visualization model and validation. Thus, we aimed to develop a preliminary clinical prediction model for the prognosis of pneumonia complicated with HF based on NGS of metagenome and hope that this model will be helpful to the assessment of prognosis of HF with pneumonia [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Investigation on the clinical trials of PARADIGM-HF [4] and PARAGON-HF [5] demonstrated that pneumonia incidence was high in patients with HF followed by 4-fold higher mortality [6]. However, the predictive factors of prognosis in patients with pneumonia complicated with HF were not fully investigated yet [7][8][9][10], especially with the help of next-generation sequencing (NGS) of metagenome.…”

Section: Introductionmentioning

confidence: 99%

Developing a Preliminary Clinical Prediction Model for Prognosis of Pneumonia Complicated with Heart Failure Based on Metagenomic Sequencing

Yang

Duan

Wang

et al. 2023

Critical Care Research and Practice

View full text Add to dashboard Cite

Background. The predictive factors of prognosis in patients with pneumonia complicated with heart failure (HF) have not been fully investigated yet, especially with the use of next-generation sequencing (NGS) of metagenome. Methods. Patients diagnosed with pneumonia complicated with HF were collected and divided into control group and NGS group. Univariate and multivariate logistic regression and LASSO regression analysis were conducted to screen the predictive factors for the prognosis, followed by nomogram construction, ROC curve plot, and internal validation. Data analysis was conducted in SPSS and R software. Results. The NGS of metagenome detected more microbial species. Univariate and multivariate logistic regression and LASSO regression analysis revealed that Enterococcus (χ2 = 7.449, P = 0.006), Hb (Wals = 6.289, P = 0.012), and ProBNP (Wals = 4.037, P = 0.045) were screened out as potential predictive factors for the prognosis. Nomogram was constructed with these 3 parameters, and the performance of nomogram was checked in ROC curves (AUC = 0.772). The specificity and sensitivity of this model were calculated as 0.579 and 0.851, respectively, with the threshold of 0.630 in ROC curve. Further internal verification indicated that the predictive value of our constructed model was efficient. Conclusion. This study developed a preliminary clinical prediction model for the prognosis of pneumonia complicated with HF based on NGS of metagenome. More objects will be collected and tested to improve the predictive model in the near future.

show abstract

Diagnostic and Prognostic Value of Lung Ultrasound B-Lines in Acute Heart Failure With Concomitant Pneumonia

Cited by 6 publications

References 42 publications

Clinical application of C-reactive protein, leukocyte and immunoglobulin in the diagnosis and treatment of infantile pneumonia at acute stage

Clinical application of C-reactive protein, leukocyte and immunoglobulin in the diagnosis and treatment of infantile pneumonia at acute stage

Interest of Lung Ultrasound in the Management of Acute Heart Failure in Post-emergency Service

Developing a Preliminary Clinical Prediction Model for Prognosis of Pneumonia Complicated with Heart Failure Based on Metagenomic Sequencing

Contact Info

Product

Resources

About