Diagnostic and Prognostic Value of Lactate Threshold and pH - Threshold Determination during Cardiopulmonary Testing in Patients with Chronic Heart Failure

Lelyavina, T. A.; Sitnikova, M. Yu.; Shlyakhto, Е. V.

doi:10.9734/bjmmr/2015/12920

Cited by 4 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study design is given in Figure 1. Clinical data are presented as metanalysis performed on the whole cohort of HF patients, including those described earlier [15,16,17,18]. All CHF patients enrolled in this project were NYHA class III, in most cases of ischemic etiology, were on stable individually adjusted medical therapy regimes, including angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists (100%), diuretics (100%), beta-blockers (100%).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the lactate (anaerobic) threshold gives an understanding of how the muscles utilize available oxygen, being a more informative indicator of overall athletic performance compared to the VO2 peak [13,14]. We have previously shown that VO2 at lactate threshold and pH threshold might be used as a significant diagnostic and prognostic marker in HF patients [15], and that the prescription of individualized aerobic exercise program based on the definition of lactate threshold resulted in significantly better therapeutic outcome (VO2 peak, left ventricular ejection fraction, exercise tolerance) than in patients who undergo aerobic training prescribed based on the estimation of the VO2 peak [16,17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Response to Personalized Exercise Therapy in Heart Failure Patients with Reduced Ejection Fraction Is Accompanied by Skeletal Muscle Histological Alterations

Lelyavina

Galenko

Ivanova

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

Heart failure (HF) is associated with skeletal muscle wasting and exercise intolerance. This study aimed to evaluate the exercise-induced clinical response and histological alterations. One hundred and forty-four HF patients were enrolled. The individual training program was determined as a workload at or close to the lactate threshold (LT1); clinical data were collected before and after 12 weeks/6 months of training. The muscle biopsies from eight patients were taken before and after 12 weeks of training: histology analysis was used to evaluate muscle morphology. Most of the patients demonstrated a positive response after 12 weeks of the physical rehabilitation program in one or several parameters tested, and 30% of those showed improvement in all four of the following parameters: oxygen uptake (VO2) peak, left ventricular ejection fraction (LVEF), exercise tolerance (ET), and quality of life (QOL); the walking speed at LT1 after six months of training showed a significant rise. Along with clinical response, the histological analysis detected a small but significant decrease in both fiber and endomysium thickness after the exercise training course indicating the stabilization of muscle mechanotransduction system. Together, our data show that the beneficial effect of personalized exercise therapy in HF patients depends, at least in part, on the improvement in skeletal muscle physiological and biochemical performance.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Response to Personalized Exercise Therapy in Heart Failure Patients with Reduced Ejection Fraction Is Accompanied by Skeletal Muscle Histological Alterations

Lelyavina

Galenko

Ivanova

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…АП определяется как интенсивность упражнений до достижения точки перегиба, при которой концентрация лактата в крови начинает нарастать быстрее, чем мышцы могут его утилизировать; таким образом, АП дает представление о том, как мышцы используют доступный кислород, являясь более информативным показателем общей работоспособности по сравнению с пиковым VO 2 [5]. Ранее было показано, что назначение индивидуальной программы аэробных упражнений, основанной на определении АП, приводит к лучшему терапевтическому результату (пик VO 2 , фракция выброса левого желудочка, толерантность к физической нагрузке), чем назначение аэробных тренировок на основе оценки пика VO 2 [6][7][8]. Также, наряду с клиническим ответом, гистологический анализ выявил уменьшение толщины как мышечных волокон, так и эндомизия после курса физических упражнений, что указывает на стабилизацию системы механотрансдукции скелетной мускулатуры пациентов в ответ на 12-нед.…”

Section: Transcriptome Analysis Of Skeletal Muscles Revealed the Effeunclassified

Transcriptome analysis of skeletal muscles revealed the effect of exercise on the molecular mechanisms regulating muscle growth and metabolism in patients with heart failure

et al. 2020

View full text Add to dashboard Cite

Aim. Heart failure (HF) is accompanied by skeletal muscle atrophy and exercise intolerance. The aim was to study the molecular mechanisms underlying the therapeutic effect of personalized exercise in patients with HF.Material and methods. RNA sequencing obtained from skeletal muscle biopsies before and after a 12-week exercise course was used to identify changes in gene expression and signaling pathways induced by the physical rehabilitation program for patients with HF.Results. We have shown that personalized exercise program in patients with HF stimulates the activation of molecular pathways regulating the differentiation and functioning of skeletal muscles: commitment of muscle progenitor cells; mechanisms regulating the calcium release and sensitivity of myofibrillar contraction, electrical excitability of the muscle membrane, synaptic vesicle proton gradient creation, maintenance of electrochemical gradients of Na+ /K+ . Also, the analysis of differentially expressed genes revealed an increase in the expression of transcription factors MyoD and MEF2, which are responsible for the differentiation of muscle stem cells, and sarcomeric genes MYOM1, MYOM2, MYH7. Along with this, we observed activation of the CYR61 expression — a potential prognostic biomarker for HF patients.Conclusion. Our data show that the beneficial effect of personalized aerobic exercise in patients with HF depends, at least in part, on an improvement in the physiological and biochemical parameters of skeletal muscle.

show abstract

“…1,2 Its measurement in clinical diagnosis is important for monitoring heart failure, respiratory insufficiency and metabolic disorders. [3][4][5] Lactate is also related to stability, storage quality and freshness in the food industry products such as beer, milk, wine and cider. [6][7][8] Lactate determination has been performed by liquid chromatography and capillary electrophoresis.…”

Section: Introductionmentioning

confidence: 99%

Os-complex-based amperometric bienzyme biosensor for continuous determination of lactate in saliva

Liu

Zhang

2015

Anal. Methods

View full text Add to dashboard Cite

An amperometric biosensor, constructed through a specific design featuring a bienzyme doped sol-gel and an Os-complex mediator layer, capped with electropolymerized polyphenol semipermeable membranes, is presented for lactate quantification in saliva. The new enzymatic biosensor exhibits impressive linear and low response times in a phosphate buffer solution of pH 7.0, and a linear dependence of the catalytic current upon lactate bulk concentration is obtained between 0.1 and 1.0 mM (r ¼ 0.997). A detection limit of 0.013 mM can be calculated as three times the standard deviation of the blank signal divided by the sensitivity of the sensor. The selectivity of the biosensor is evaluated by adding common interferent species such as ascorbic acid and uric acid to 0.2 mM lactate; current responses for the interferents are nearly negligible compared to that of the lactate, indicating excellent discriminatory selectivity. The lactate biosensor presents remarkable operational stability in 0.2 mM lactate over a 2 h period and good repeatability in a carry-over test by alternating lactate concentrations. The successful application to whole human saliva samples for continuous monitoring of lactate dynamics makes the amperometric bienzyme biosensor hold considerable promise for diverse biomedical and fitness applications.

show abstract

Diagnostic and Prognostic Value of Lactate Threshold and pH - Threshold Determination during Cardiopulmonary Testing in Patients with Chronic Heart Failure

Cited by 4 publications

References 15 publications

Clinical Response to Personalized Exercise Therapy in Heart Failure Patients with Reduced Ejection Fraction Is Accompanied by Skeletal Muscle Histological Alterations

Clinical Response to Personalized Exercise Therapy in Heart Failure Patients with Reduced Ejection Fraction Is Accompanied by Skeletal Muscle Histological Alterations

Transcriptome analysis of skeletal muscles revealed the effect of exercise on the molecular mechanisms regulating muscle growth and metabolism in patients with heart failure

Os-complex-based amperometric bienzyme biosensor for continuous determination of lactate in saliva

Contact Info

Product

Resources

About