Diagnostic and prognostic value of tumor-infiltrating B cells in lymph node metastases of papillary thyroid carcinoma

Yang, Zeyu; Li, Yin; Zeng, Yiyu; Li, Yao; Chen, Hongdan; Yin, Supeng; Zhang, Fan; Yang, Wang

doi:10.1007/s00428-021-03137-y

Cited by 14 publications

(9 citation statements)

References 45 publications

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“…Some other studies suggest that lymphocyte accumulations in and around the thyroid tumors are also seen as the body's defense against the tumors [ 29 , 30 ]. Similarly, lymphocyte infiltration in or around the tumor in PTC patients is associated with a good prognosis and protects against tumor recurrence [ 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

Incidental Papillary Microcarcinoma and Papillary Thyroid Carcinoma in Multinodular Goiter

Arican¹,

Öztürk

Sağer

et al. 2023

Analytical Cellular Pathology

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Introduction. This study aimed to examine the incidence of incidental papillary microcarcinoma (PMC) and papillary thyroid carcinoma (PTC) in patients with benign multinodular goiter (MNG) and to compare their relationship with some prognostic factors from a new perspective. Methods. Bilateral total thyroidectomy (BTT) was used to evaluate the data of 716 patients who underwent a surgery for MNG. The prognostic data for these tumors and the relationship between patients with bilateral and multifocal tumors were evaluated using statistical tests. Results. Papillary carcinomas were detected in 201 patients, PMC in 134 of them, and PTCs in 67. Bilaterality was more common in patients with PTCs than in those with PMC. The incidence of bilaterality in male patients with PTC was statistically more common. The presence of intra-tumoral lymphocytes was higher in multifocal PTC cases than in unifocal PTC cases. Conclusion. The results revealed that the number of PMC s was high in incidental tumors, and patients with PTC with male sex, bilaterality, multifocality, and tumor capsule invasion were associated with poor prognosis.

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Section: Resultsmentioning

confidence: 99%

Incidental Papillary Microcarcinoma and Papillary Thyroid Carcinoma in Multinodular Goiter

Arican¹,

Öztürk

Sağer

et al. 2023

Analytical Cellular Pathology

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“…Thus, the long-term use of thyroid hormone replacement drugs can be avoided, and it has little effect on patients' quality of life (36). The ablation is generally performed under local anesthesia, and due to precise positioning by ultrasound, the location, size, texture, and blood supply of the tumor nodules can be comprehensively explored (37). Additionally, by reducing the risk of tissue damage around the thyroid gland, such as the esophagus, trachea, and parathyroid glands, and protecting the surrounding tissue by the intraoperative fluid barrier, the treatment effect is enhanced and the risk of complications is reduced.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of microwave ablation versus conventional open surgery for the treatment of papillary thyroid microcarcinoma: a systematic review and meta-analysis

Wang¹,

Jiang²,

Liu³

et al. 2022

Gland Surg

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Background: Microwave ablation (MWA) technology has been applied to the treatment of papillary thyroid microcarcinoma (PTMC); however, its use as an alternative to conventional open surgery (OS) remains controversial, because it belongs to non-tumor radical treatment. Our article sought to compare the efficacy and safety of MWA and OS in the treatment of PTMC.Methods: We searched seven databases for studies evaluating the treatment of patients with PTMC using MWA as intervention group and OS as control group, the main outcome contained intra-operative, postoperative and follow-up outcomes. Review Manager 5.4 was used to estimate the effects of the results of the included articles and Cochrane Risk of Bias 2.0 was used to assess the risk of bias. The data were pooled to calculate the mean differences (MD) with 95% confidence intervals (CIs) for the continuous data and the odds ratio (OR) with 95% CIs for the dichotomous data.Results: A total of 13 studies, comprising 1,088 and 1,081 patients in the MWA and OS groups, respectively, were identified that compared the results of MWA to OS in the treatment of PTMC. All of the articles were at low risk of bias. There were no differences in terms of the recurrence rate (OR =0.80, 95% CI: 0.37 to 1.77; P=0.59) or lymph node metastasis (OR =0.71, 95% CI: 0.26 to 1.95; P=0.51) between the 2 groups. However, compared to the OS group, the MWA group had a shorter operation time (MD =-44.

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“…A higher TB score was associated with a better prognosis [19]. High infiltration of B cells was closely associated with a better prognosis in a variety of tumor types, including breast, ovarian, renal cell, thyroid papillary and lung cancers [20][21][22][23]. Furthermore, TIL-Bs were related to negative lymphatic invasion in gastric cancer, lymph node metastases in papillary thyroid carcinoma, and negative distant metastasis in colorectal cancer [23,24].…”

Section: Association Between B Cells and Prognosis Of Tumor Metastasismentioning

confidence: 98%

“…High infiltration of B cells was closely associated with a better prognosis in a variety of tumor types, including breast, ovarian, renal cell, thyroid papillary and lung cancers [20][21][22][23]. Furthermore, TIL-Bs were related to negative lymphatic invasion in gastric cancer, lymph node metastases in papillary thyroid carcinoma, and negative distant metastasis in colorectal cancer [23,24]. Elevated numbers of peripheral B cells could also help to improve the survival of locally advanced or metastatic pancreatic cancer [25].…”

Section: Association Between B Cells and Prognosis Of Tumor Metastasismentioning

confidence: 99%

B cells in tumor metastasis: friend or foe?

Xu¹,

Mao²,

Yang³

et al. 2023

Int. J. Biol. Sci.

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Metastasis is an important cause of cancer-related death. Immunotherapy may be an effective way to prevent and treat tumor metastasis in the future. Currently, many studies have focused on T cells, whereas fewer have focused on B cells and their subsets. B cells play an important role in tumor metastasis. They not only secrete antibodies and various cytokines but also function in antigen presentation to directly or indirectly participate in tumor immunity. Furthermore, B cells are involved in both inhibiting and promoting tumor metastasis, which demonstrates the complexity of B cells in tumor immunity. Moreover, different subgroups of B cells have distinct functions. The functions of B cells are also affected by the tumor microenvironment, and the metabolic homeostasis of B cells is also closely related to their function. In this review, we summarize the role of B cells in tumor metastasis, analyze the mechanisms of B cells, and discuss the current status and prospects of B cells in immunotherapy.

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Diagnostic and prognostic value of tumor-infiltrating B cells in lymph node metastases of papillary thyroid carcinoma

Cited by 14 publications

References 45 publications

Incidental Papillary Microcarcinoma and Papillary Thyroid Carcinoma in Multinodular Goiter

Incidental Papillary Microcarcinoma and Papillary Thyroid Carcinoma in Multinodular Goiter

The efficacy and safety of microwave ablation versus conventional open surgery for the treatment of papillary thyroid microcarcinoma: a systematic review and meta-analysis

B cells in tumor metastasis: friend or foe?

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