Diagnostic and Prognostic Value of Serum miR-296-5p and miR-28-3p in Human Gastric Cancer

Guo, Yuntong; Cui, Xiaolong; Ma, Xiaobo; Ren, Aigang; Huang, He

doi:10.1089/cbr.2020.4144

Cited by 9 publications

(4 citation statements)

References 27 publications

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“…MiRNA 487b-3p is involved in colon cancer, osteosarcoma, and anaphylactic reactions [38,39]. MiRNA 28-3p is involved in Alzheimer's, nasopharyngeal cancer, gastric cancer, thyroid cancer, and esophageal squamous cell carcinoma [40,41,42]. MiRNA 532-5p is involved in breast cancer, glioma, gastric cancer, ovarian cancer, renal carcinoma, and ischemic stroke [27,43,44,45,46,47].…”

Section: Discussionmentioning

confidence: 99%

Potential microRNA biomarker panel for predicting evolution of pancreatitis to pancreatic ductal adenocarcinoma

Nuthakki¹,

Utti²,

McCalla³

2023

Preprint

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Purpose Pancreatitis is one of the most important risk factors for pancreatic ductal adenocarcinoma (PDAC). PDAC is a silent, aggressive malignancy that has less than 5% survival rate at 5 years. Detection at early stage and resection of PDAC significantly improves survival. A differentially expressed microRNA panel was sought that could predict the risk of progression to PDAC from pancreatitis. Methods Differentially expressed microRNA (DEM) in serum that were common between pancreatitis and PDAC were extracted from two microarray GSE datasets containing pancreatitis, PDAC, and control samples. Eight groups of DEM were derived from multiple bioinformatics methods such as differential expression, miRNA interaction networks, target gene prediction tools, functional enrichment analysis, and machine learning models. The functional enrichment pathway of these groups were identified. Results These groups were trained on the original datasets and were used to predict pancreatic cancer in a validation set consisting of six other GSE datasets containing pancreatic cancer and controls. The miRNA panel with the highest precision and recall was the group derived from the target hub genes with the highest interaction (hsa-miR-28-3p, 320b, 320c, 320d, 532-5p, and 423-5p, with a mean F1 of 0.968, mean recall of 0.99, mean precision of 0.947, and mean AUC of 0.995). Conclusion These results provide a potential biomarker to identify and follow individuals at high risk for pancreatic cancer after pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Potential microRNA biomarker panel for predicting evolution of pancreatitis to pancreatic ductal adenocarcinoma

Nuthakki¹,

Utti²,

McCalla³

2023

Preprint

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“…miR-28-3p was discovered to have a biological function role in several diseases. The level of circulating miR-28-3p has significantly changed in several diseases, including severe asthma [18], colorectal cancer [19], gastric cancer [20], amyotrophic lateral sclerosis[21], non-ST-segment elevation acute coronary syndrome [22], pulmonary embolism [23],…”

Section: Discussionmentioning

confidence: 99%

MiR-28-3p regulates high glucose-induced endothelial dysfunction by targeting CXXC5

Wang,

Fang,

Dong

et al. 2023

Arch Med Sci

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IntroductionIntroduction: Data from the CEO database shows microRNA (miR) -28-3p levels are elevated in diabetic patients. Nevertheless, the role of miR-28-3p in peripheral artery disease with diabetes have not been investigated.Material and methodsThe level of miR-28-3p, CXXC5, CXXC-type zinc finger protein 5, and CXXC5’s downstream molecules as well as endothelial function were investigated. Dual luciferase analyses were used to confirm the binding site of miR-28-3p and CXXC5.ResultsResults: Under high-glucose condition, miR-28-3p expression is increased whereas CXXC5 expression is downregulated. Overexpression of miR-28-3p increased cell apoptosis and inhibited cell proliferation, migration, and vessel formation, whilst inhibiting its expression had the opposite effect. The overexpression and inhibition of miR-28-3p could also influence both the mRNA and protein levels of CXXC5 and its known downstream molecules. Analysis of bioinformatics data revealed a potential binding site for miR-28-3p and CXXC5. Dual luciferase analyses demonstrated that miR-28-3p suppressed CXXC5 expression by targeting the 3'-untranslated region (3'-UTR) of CXXC5. Following that, we overexpressed both miR-28-3p and CXXC5. The level of CXXC5 and its known downstream signaling molecules decreased with miR-28-3p overexpression alone. As anticipated, co-overexpression of miR-28-3p and CXXC5 partially reversed the effect of miR-28-3p mimics.ConclusionsConclusion: These findings indicated that miR-28-3p regulated high glucose-induced endothelial dysfunction by targeting CXXC5.

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“…Moreover, decreased expression of miRNA-100 and miRNA-125b paves the way for overexpression of IGF2 and subsequent cancer stem cell features in hepatocellular carcinoma [ 299 ]. Further studies have shown that miRNAs can be considered as reliable biomarkers for cancer diagnosis [ 300 , 301 ]. Because exosomes are capable of transmitting miRNAs, we dedicated this section to the study of exosomal miRNAs in the regulation of cancer progression.…”

Section: Exosomal Mirnasmentioning

confidence: 99%

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

et al. 2022

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Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment. Graphical Abstract

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Diagnostic and Prognostic Value of Serum miR-296-5p and miR-28-3p in Human Gastric Cancer

Cited by 9 publications

References 27 publications

Potential microRNA biomarker panel for predicting evolution of pancreatitis to pancreatic ductal adenocarcinoma

Potential microRNA biomarker panel for predicting evolution of pancreatitis to pancreatic ductal adenocarcinoma

MiR-28-3p regulates high glucose-induced endothelial dysfunction by targeting CXXC5

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

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