Diagnostic and prognostic value of microRNA423-5p in patients with heart failure

Abstract

Objectives MicroRNAs are considered as a class of potential biomarkers for heart failure. This study aimed to retrospectively evaluate the diagnostic and prognostic value of microRNA423-5p in patients with heart failure. Methods A total of 98 patients diagnosed with heart failure were enrolled in the observation group, while 30 healthy volunteers without heart failure were enrolled for the control group. The prognostic significance of microRNA423-5p in patients with heart failure was assessed through laboratory parameter assessments, cardiac ultrasound evaluations, and subsequent follow-up assessments. Results In comparison to the control group, the observation group exhibited notably elevated levels of microRNA423-5p and BNP, as well as significantly lower left ventricular ejection fraction (LVEF) values (P < 0.05). Additionally, within the observation group, a positive correlation was observed between higher heart function ratings and increased levels of microRNA423-5p and B-type natriuretic peptide (BNP), along with a more pronounced decrease in LVEF values (P < 0.05). Spearman correlation analysis revealed a significant positive correlation between microRNA423-5p and BNP indicators (rs = 0.850, P < 0.001). The observation group was monitored for a period of one year, with hospitalization due to recurrent heart failure or all-cause mortality serving as the designated follow-up endpoint. The event group exhibited elevated levels of microRNA423-5p and BNP, along with a decreased LVEF (P < 0.05). The ROC curve analysis indicated that both microRNA423-5p + BNP + LVEF and microRNA423-5p + BNP exhibited strong predictive capabilities, with respective areas under the curve of 0.839 and 0.814. Conclusions Elevated levels of microRNA423-5p in the serum of patients with heart failure suggest its potential utility as a novel biomarker for both the diagnosis and prognosis of this condition.