Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer

Yörüker, Ebru Esin; Keskin, Metin; Kulle, Cemil Burak; Holdenrieder, Stefan; Gezer, Uğur

doi:10.3892/br.2018.1116

Cited by 40 publications

(35 citation statements)

References 29 publications

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“…lncRNAs have essential biological functions, and H19 is one of the few well‐characterized lncRNAs, which is an imprinted and maternally expressed transcript . Aberrant expression of H19 has been associated with numerous disease conditions . The current study showed that BA patients had significantly higher levels of H19 mRNA in livers when compared to control subjects, which indicates that H19 may play a role in the pathogenesis of BA.…”

Section: Discussionsupporting

confidence: 51%

Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia

et al. 2019

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Biliary atresia (BA) is a neonatal liver disease featuring cholestasis and severe liver fibrosis (LF). Despite advances in the development of surgical treatment, lacking an early diagnostic marker and intervention of LF invariably leads to death from end-stage liver disease in the early years of life. We previously reported that knockout of sphingosine 1-phosphate receptor 2 (S1PR2) protected mice from bile duct ligation (BDL)-induced cholangiocyte proliferation and LF. Our recent studies further showed that both hepatic and serum exosomal long noncoding RNA H19 (lncR-NAH19) levels are correlated with cholestatic injury in multidrug resistance 2 knockout (Mdr2−/−) mice. However, the role of lncRNAH19 in BA progression remains unclear. Here, we show that both hepatic and serum exosomal H19 levels are positively correlated with severity of fibrotic liver injuries in BA patients. H19 deficiency protects mice from BDL-induced cholangiocyte proliferation and LF by inhibiting bile-acid–induced expression and activation of S1PR2 and sphingosine kinase 2 (SphK2). Furthermore, H19 acts as a molecular sponge for members of the microRNA let-7 family, which results in up-regulation of high-mobility group AT-hook 2 (HMGA2), a known target of let-7 and enhancement of biliary proliferation. Conclusion: These results indicate that H19 plays a critical role in cholangiocyte proliferation and cholestatic liver injury in BA by regulating the S1PR2/SphK2 and let-7/HMGA2 axis. Serum exosomal H19 may represent a noninvasive diagnostic biomarker and potential therapeutic target for BA.

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Section: Discussionsupporting

confidence: 51%

Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia

et al. 2019

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“…H19 is an imprinted and maternally expressed transcript, which is one of the few well-characterized lncRNA [32,33]. Aberrant expression of H19 has been related to a variety of human diseases [34][35][36][37][38]. The current study showed that IPF patients had higher levels of H19 mRNA in lungs when compared to the control subjects using a public datasets, which indicates that H19 may play an important role in the pathogenesis of IPF.…”

Section: Discussionsupporting

confidence: 49%

Long non-coding RNA H19 deficiency ameliorates bleomycin-induced pulmonary inflammation and fibrosis

Wan

TIAN²,

DU³

et al. 2020

Preprint

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Background: The poor understanding of pathogenesis in idiopathic pulmonary fibrosis (IPF) impaired development of effective therapeutic strategies. The aim of the current study is to investigate the roles of long non-coding RNA H19 (lncRNA H19) in the pathogenesis of IPF. Methods: Bleomycin was used to induce pulmonary inflammation and fibrosis in mice. The mRNAs and proteins expression in lung tissues was determined by quantitative real-time polymerase chain reaction and western blot. H19 knockout (H19-/-) mice were generated by CRISPR/Cas9 and used to investigate the roles of H19 in the pulmonary inflammation and fibrosis in vivo.Results: The expression of H19 mRNA was up-regulated in fibrotic lungs patients with IPF as well as in lungs tissues that obtained from bleomycin-treated mice. H19-/- mice suppressed bleomycin-mediated pulmonary inflammation and inhibited the Il6/Stat3 signaling. H19 deficiency ameliorated bleomycin-induced pulmonary fibrosis and repressed the activation of TGF-β/Smad and S1pr2/Sphk2 in the lungs of bleomycin-treated mice. Conclusions: Our data suggests that H19 is a profibrotic lncRNA and a potential therapeutic target for pulmonary fibrosis.

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“…H19-lncRNA regulates gene expression of CDK4, CCND, and certain cancer-related proteins, such as RB1, and indirectly the activity of β-catenin via reduction of CDK8 expression by interacting with macroH2A [68]. H19 lncRNA is highly abundant in many tumors, including CRC [69]. Yoshimizu et al [70] demonstrated that lack of H19-lncRNA expression may be considered as an initiating step in increasing the number of polyp appearance in APC mutated carcinogenesis mice model.…”

Section: Long Non-coding Rnas (Lncrnas)mentioning

confidence: 99%

Colorectal Adenomas—Genetics and Searching for New Molecular Screening Biomarkers

Siskova

Červená

Král

et al. 2020

IJMS

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Colorectal cancer (CRC) is a malignant disease with an incidence of over 1.8 million new cases per year worldwide. CRC outcome is closely related to the respective stage of CRC and is more favorable at less advanced stages. Detection of early colorectal adenomas is the key to survival. In spite of implemented screening programs showing efficiency in the detection of early precancerous lesions and CRC in asymptomatic patients, a significant number of patients are still diagnosed in advanced stages. Research on CRC accomplished during the last decade has improved our understanding of the etiology and development of colorectal adenomas and revealed weaknesses in the general approach to their detection and elimination. Recent studies seek to find a reliable non-invasive biomarker detectable even in the blood. New candidate biomarkers could be selected on the basis of so-called liquid biopsy, such as long non-coding RNA, microRNA, circulating cell-free DNA, circulating tumor cells, and inflammatory factors released from the adenoma into circulation. In this work, we focused on both genetic and epigenetic changes associated with the development of colorectal adenomas into colorectal carcinoma and we also discuss new possible biomarkers that are detectable even in adenomas prior to cancer development.

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Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer

Cited by 40 publications

References 29 publications

Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia

Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia

Long non-coding RNA H19 deficiency ameliorates bleomycin-induced pulmonary inflammation and fibrosis

Colorectal Adenomas—Genetics and Searching for New Molecular Screening Biomarkers

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