Diagnostic and Therapeutic Applications of Exosomes in Cancer with a Special Focus on Head and Neck Squamous Cell Carcinoma (HNSCC)

Ebnoether, Eliane; Müller, Laurent

doi:10.3390/ijms21124344

Cited by 26 publications

(25 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though exosomes have been widely employed to investigate head and neck squamous cell carcinomas [100][101][102][103], unraveling the biologic mechanisms and application of salivary tumor -derived exosomes is still an evolving science [67]. This emergent field of saliva-exosomics warrants further investigation.…”

Section: Salivary Exosomes and Oral Cancermentioning

confidence: 99%

Diagnostic Potential of Salivary Exosomes in Oral Cancer

Adeola¹,

Holmes²,

Temilola³

2022

Oral Cancer - Current Concepts and Future Perspectives

View full text Add to dashboard Cite

“Omics” based concepts and techniques are gaining momentum in the field of oral medicine, spurred on by rapid advancements within the field of precision diagnostics and therapeutics. Oral cancer, specifically oral squamous cell carcinoma is the most common head and neck cancer, posing both diagnostic and prognostic challenges globally. Saliva offers several advantages as a diagnostic tool and has gained recognition as a biological medium for liquid biopsy. Salivary biomarkers, such as exosomes not only contain the full spectrum of genomic, lipidomic and proteomic material from its cell of origin, but are also more stable and consistently measurable in saliva due to their phospholipid structural protection of their merchandise/contents. Salivary exosomes are mediators in communication and transfer of contents between cancer and normal cells and thus key role players in mediating the tumor environment. Even though exosomes have been widely employed to investigate systemic diseases including head and neck cancers, unraveling the biologic mechanisms, scope of application of salivary tumor-derived exosomes and overcoming restrictions in this emergent field of saliva-exosomics warrants further investigation.

show abstract

Section: Salivary Exosomes and Oral Cancermentioning

confidence: 99%

Diagnostic Potential of Salivary Exosomes in Oral Cancer

Adeola¹,

Holmes²,

Temilola³

2022

Oral Cancer - Current Concepts and Future Perspectives

View full text Add to dashboard Cite

show abstract

“…Exosomes are released by practically all cells and found in nearly all body fluids [ 30 ]. Exosomes differ from other EVs by their biogenesis through the endosomal compartment, thus carrying, for example, tsg101 as a typical marker [ 31 ]. They carry a lot of the molecular characteristics of the parental cell and due to their small size can reach nearly every part of the body.…”

Section: Exosomes: the Smallest Group Of Evsmentioning

confidence: 99%

“…After this huge run, he is said to have collapsed and died [ 32 ]. Exosomes are also mostly used up after transmitting their message [ 31 ]. In order to keep the communication system running and to have a constant influence on the organism, and in particular on the immune system, tumor cells constantly produce large amounts of exosomes, called tumor-derived exosomes (TEX).…”

Section: Exosomes: the Smallest Group Of Evsmentioning

confidence: 99%

Exosomes: Small EVs with Large Immunomodulatory Effect in Glioblastoma

Benecke

Coray

Umbricht

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Glioblastomas are among the most aggressive tumors, and with low survival rates. They are characterized by the ability to create a highly immunosuppressive tumor microenvironment. Exosomes, small extracellular vesicles (EVs), mediate intercellular communication in the tumor microenvironment by transporting various biomolecules (RNA, DNA, proteins, and lipids), therefore playing a prominent role in tumor proliferation, differentiation, metastasis, and resistance to chemotherapy or radiation. Exosomes are found in all body fluids and can cross the blood–brain barrier due to their nanoscale size. Recent studies have highlighted the multiple influences of tumor-derived exosomes on immune cells. Owing to their structural and functional properties, exosomes can be an important instrument for gaining a better molecular understanding of tumors. Furthermore, they qualify not only as diagnostic and prognostic markers, but also as tools in therapies specifically targeting aggressive tumor cells, like glioblastomas.

show abstract

“…PD-L1 on these vesicles may inhibit the anti-tumor response by down-regulating the expression of CD69 on effector T cells. Ebnoether et al (102) showed that the expression of plasma-released sEV membrane protein TGF-b was increased in patients with active head and neck cancer (HNC), and the expression in patients with III/IV stage was higher than that in I/II stage, which may serve as a progressive marker of HNC.…”

Section: Head and Neck Cancermentioning

confidence: 99%

Advances in Biological Function and Clinical Application of Small Extracellular Vesicle Membrane Proteins

Huang

Chen

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

Small extracellular vesicles are membrane-bound vesicles secreted into extracellular spaces by virtually all types of cells. These carry a large number of membrane proteins on their surface that are incorporated during their biogenesis in cells. The composition of the membrane proteins hence bears the signature of the cells from which they originate. Recent studies have suggested that the proteins on these small extracellular vesicles can serve as biomarkers and target proteins for the diagnosis and treatment of diseases. This article classifies small extracellular vesicle membrane proteins and summarizes their pathophysiological functions in the diagnosis and treatment of diseases.

show abstract

Diagnostic and Therapeutic Applications of Exosomes in Cancer with a Special Focus on Head and Neck Squamous Cell Carcinoma (HNSCC)

Cited by 26 publications

References 112 publications

Diagnostic Potential of Salivary Exosomes in Oral Cancer

Diagnostic Potential of Salivary Exosomes in Oral Cancer

Exosomes: Small EVs with Large Immunomodulatory Effect in Glioblastoma

Advances in Biological Function and Clinical Application of Small Extracellular Vesicle Membrane Proteins

Contact Info

Product

Resources

About