Diagnostic and Therapeutic Applications of Quantum Dots in Nanomedicine

Kamila, Sukanta; McEwan, Conor; Costley, David; Atchison, Jordan; Sheng, Yinjie; Hamilton, Graham R. C.; Fowley, Colin; Callan, John F.

doi:10.1007/978-3-319-22942-3_7

Cited by 29 publications

(14 citation statements)

References 77 publications

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“…According to Fakruddin et al [8], thanks to the achievements of nanotechnology, it will soon be possible to increasingly or even fully control the matter structure; hence, to overcome numerous obstacles, the medicine is nowadays struggling against. For example, by using quantum dots, nanotechnology might greatly assist in an early stage cancer diagnosis and therapy [9]. The regeneration and remodeling of damaged neuronal connections is going to be possible, thanks to dendrimers [10].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e.g., in nanomedicine. NMs and NPs are perceived as very promising in cancer therapy since they can perform as drug carriers, as well as photo- or sonosensitizers (compounds that generate the formation of reactive oxygen species as a result of either electromagnetic radiation excitation with an adequate wavelength or ultrasound activation, respectively). Consequently, two new treatment modalities, the photodynamic therapy (PDT) and the sonodynamic therapy (SDT) have been created. The attachment of ligands or antibodies to NMs or to NPs improve their selective distribution into the targeted organ or cell; hence, the therapy effectiveness can be improved. An important advantage of the targeted tumor treatment is lowering the cyto- and genotoxicity of active substance towards healthy cells. Therefore, both PDT and SDT constitute a valuable alternative to chemo- or radiotherapy. The vital role in cancer eradication is attributed to two inorganic sensitizers in their nanosized scale: titanium dioxide and zinc oxide.

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Section: Introductionmentioning

confidence: 99%

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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“…Though these probes have not yet been used in humans, combining them with existing imagining and surgical technology has the potential to increase the efficacy of future surgeries. A great deal of current research and clinical trials are examining the potential use of quantum dots as an alternative fluorescent marker (65,(142)(143)(144)(145). These molecules would overcome the obstacle of iodine allergy and can be easily modified to alter their biodistribution and fluorescence emission.…”

Section: Discussionmentioning

confidence: 99%

Advances in fluorescent-image guided surgery

2016

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“…Typically they consist of a group IIB metal, mostly cadmium combined with a chalcogenic element (e.g. CdS, CdSe or CdTe) with all three nanocrystal dimensions in the 2-10 nm range [154]. The peculiarity of these nanoscale semiconductors is that they consist of only a few hundred to a few thousand atoms and, in that dimension, QDs acquire properties different from the bulk solid because of size quantization effects, leading to restricted mobility of electrons and holes.…”

Section: Quantum Dots (Qds)mentioning

confidence: 99%

Strategies for optimizing the delivery to tumors of macrocyclic photosensitizers used in photodynamic therapy (PDT)

Moret

Reddi

2017

J. Porphyrins Phthalocyanines

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This review briefly summaries the principles and mechanisms of action of photodynamic therapy (PDT) as concerns its application in the oncological field, highlighting its drawbacks and some of the strategies that have been or are being explored to overcome them. The major aim is to increase the efficiency and selectivity of the photosensitizer (PS) uptake in the cancer cells for optimizing the PDT effects on tumors while sparing normal cells. Some attempts to achieve this are based on the conjugation of the PS to biomolecules (small ligands, peptides) functioning as carriers with the ability to efficiently penetrate cells and/or specifically recognize and bind proteins/receptors overexpressed on the surface of cancer cells. Alternatively, the PS can be entrapped in nanocarriers derived from various types of materials that can target the tumor by exploiting the enhanced permeability and retention (EPR) effects. The use of nanocarriers is particularly attractive because it allows the simultaneous delivery of more than one drug with the possibility of combining PDT with other therapeutic modalities.

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Diagnostic and Therapeutic Applications of Quantum Dots in Nanomedicine

Cited by 29 publications

References 77 publications

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Advances in fluorescent-image guided surgery

Strategies for optimizing the delivery to tumors of macrocyclic photosensitizers used in photodynamic therapy (PDT)

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