Diagnostic and Therapeutic Approach to Cats with Chronic Diarrhoea

Marks, Stanley L.

doi:10.1053/jfms.2000.0081

Cited by 3 publications

(6 citation statements)

References 7 publications

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“…These may include parasites (Giardia, hookworms), genetic susceptibility, stress, dietary factors (protein hypersensitivity) or reduced immune tolerance (Simpson, 1998). Bacterial infections with Clostridium difficile have been implicated in cases of diarrhoea and enterocolitis in cats (Marks, 2000) and Clostridium perfringens , Escherichia coli and Campylobacter spp. in dogs (Nair et al., 1985; Beutin, 1999; Brown et al., 1999; Sasaki et al., 1999).…”

Section: Introductionmentioning

confidence: 99%

Molecular characterisation of the gut microflora of healthy and inflammatory bowel disease cats using fluorescence in situ hybridisation with special reference to Desulfovibrio spp.

Inness

McCartney

Khoo

et al. 2006

Animal Physiology Nutrition

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Inflammatory bowel disease (IBD) is a common cause of chronic large bowel diarrhoea in cats. Although the aetiology of IBD is unknown, an immune-mediated response to a luminal antigen is thought to be involved. As knowledge concerning the colonic microflora of cats is limited and requires further investigation, the purpose of this study was to determine the presence of specific bacterial groups in normal and IBD cats, and the potential role they play in the health of the host. Total bacterial populations, Bacteroides spp., Bifidobacterium spp., Clostridium histolyticum subgp., Lactobacillus-Enterococcus subgp. and Desulfovibrio spp. were enumerated in 34 healthy cats and 11 IBD cats using fluorescence in situ hybridisation. The study is one of the first to show the presence of Desulfovibrio in cats. Total bacteria, Bifidobacterium spp. and Bacteroides spp. counts were all significantly higher in healthy cats when compared with IBD cats, whereas Desulfovibrio spp. (producers of toxic sulphides) numbers were found to be significantly higher in colitic cats. The information obtained from this study suggests that modulation of bacterial flora by increasing bifidobacteria and decreasing Desulfovibrio spp. may be beneficial to cats with IBD. Dietary intervention may be an important aspect of their treatment.

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Section: Introductionmentioning

confidence: 99%

Molecular characterisation of the gut microflora of healthy and inflammatory bowel disease cats using fluorescence in situ hybridisation with special reference to Desulfovibrio spp.

Inness

McCartney

Khoo

et al. 2006

Animal Physiology Nutrition

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“…Produkowany przez te drobnoustroje siarkowodór hamuje proces utleniania maślanów w komórkach enterocytów, co prawdopodobnie -przy udziale innych czynników -może prowadzić do rozwoju zmian patologicznych w komórkach jelita i rozwoju colitis (28,31). Z kolei w innej publikacji Marks (24), opisującej etiopatogenezę NZJ zasugerowano, że na rozwój zapalenia jelita grubego u kotów może mieć wpływ zakażenie bakteriami z gatunku Clostridium difficile.…”

Section: Etiologia I Patogenezaunclassified

Feline inflammatory bowel disease

Stęgierska¹,

Puchalski²,

Staniec³

et al. 2019

Medycyna Weterynaryjna

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Inflammatory bowel disease (IBD) is one of the most common causes of chronic clinical signs from the gastrointestinal tract, associated with histological evidence of inflammation in the lamina propria of the small and/or large intestine in cats. The underlying etiopathogenesis of this inflammation remains unclear. IBD is probably caused by a combination of environmental and immune factors in genetically susceptible individuals. The process of diagnosing IBD involves several steps and is based on the exclusion of other causes of gastrointestinal signs and on the confirmation of the presence of inflammatory infiltration in the intestinal wall by histopathological assessment of biopsies. The treatment is based on anti-inflammatory and immunosuppressive drugs. In addition, dietotherapy, antibiotics, antiparasitic drugs, prebiotics, probiotics and supplementation of vitamin b12 are also used. For most patients, the response to treatment is satisfactory, but the maintenance of clinical remission in most of them may require anti-inflammatory drugs for the rest of their lives.

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“…A cat that is unwell may present with inappetence or anorexia as one of the first clinical signs. 1 Cats have a higher protein and amino acid requirement than most other species and become protein malnourished quickly when anorexic. 2 Cats are dependent on protein for gluconeogenesis and are unable to downregulate production of aminotransferases and urea cycle enzymes in response to low protein intake.…”

Section: Detrimental Effects Of Prolonged Inadequate Nutritionmentioning

confidence: 99%

“…4 A number of other neurotransmitters such as catecholamines, serotonin and gamma-aminobutyric acid (GABA) also have a physiological role in the control of food intake, as described schematically in the box below. 1,4…”

Section: Appetite Regulationmentioning

confidence: 99%

“…Food aversion may be an important factor in feline inappetence, and can be associated with any food that is offered when a cat is feeling nauseous, vomiting, 1 painful or indisposed. 9 This aversion may persist even after recovery and highlights the importance of addressing these issues, not only to help improve appetite and hydration status, but also to help prevent continued rejection of certain foods after the patient returns home.…”

Section: Appetite Regulationmentioning

confidence: 99%

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