Diagnostic and therapeutic aspects of neuregulin-1: A review

Abstract

In recent decades, the prospect of using a biomarker strategy for early personalized diagnosis of cardiovascular pathology has been actively explored. The use of new markers seems promising, and the search for an ideal marker is actively ongoing, which will make it possible to understand many mechanisms of cardiovascular diseases. In recent years, the attention of scientists has been actively focused on studying the role of neuregulin-1 as a laboratory biological marker in cardiac pathology. Neuregulins belong to a superfamily of epidermal growth factors that are synthesized by the vascular endothelium in response to ischemia, adrenergic stimulation, and oxidative stress. A number of studies have shown the potentially important diagnostic and prognostic value of assessing neuregulin-1 as a biological marker. It is expected that further scientific and clinical studies will demonstrate the possibility of using this marker as an additional laboratory tool for diagnosing, risk stratifying and predicting cardiovascular events in patients with cardiovascular pathology. The therapeutic effect of recombinant neuregulin-1 on reducing morbidity and mortality in cardiac patients remains to be assessed in more detail.