Diagnostic and therapeutic considerations in idiopathic hypereosinophilia with warm autoimmune hemolytic anemia

Abstract

Hypereosinophilic syndrome (HES) encompasses numerous diverse conditions resulting in peripheral hypereosinophilia that cannot be explained by hypersensitivity, infection, or atopy and that is not associated with known systemic diseases with specific organ involvement. HES is often attributed to neoplastic or reactive causes, such as chronic eosinophilic leukemia, although a majority of cases remains unexplained and are considered idiopathic. Here, we review the current diagnosis and management of HES and present a unique case of profound hypereosinophilia associated with warm autoimmune hemolytic anemia requiring intensive management. This case clearly illustrates the limitations of current knowledge with respect to hypereosinophilia syndrome as well as the challenges associated with its classification and management.

The Pattern of Eosinophil Count among Nigerians with Frequent Use of the Commonly Available Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

“…The findings of eosinophil in mural thrombus associated with acute coronary events like myocardial infarction, a condition associated with platelet aggregation further confirms the symbiotic association between the two [33]. The negative relationship between eosinophil count and the hematocrit in this study is in agreement with findings by Sweidan et al [18] who reported a case of autoimmune hemolytic anemia with Ibuprofen use. The pro-inflammatory features of eosinophils stimulate hemolysis, from disruption in membrane proteins, leading to altered cell cellular adhesion, increased permeability and osmotic fragility.…”