Diagnostic and Therapeutic Implications of Organic Delusional Disorder due to Tuberculous Adrenalitis

Govind, Pooja; Subramanian, Karthick; Kumar, S. Vinod

doi:10.1155/2022/5056976

Cited by 4 publications

(4 citation statements)

References 7 publications

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“… 12 Another 56-year-old male was admitted for organic delusional disorder at onset of tuberculosis-associated AD. 13 …”

Section: Resultsmentioning

confidence: 99%

“…12 Another 56-year-old male was admitted for organic delusional disorder at onset of tuberculosis-associated AD. 13 Cardiologic anomalies were reported as a first step in identifying AD. A 63-year-old male was admitted for junctional rhythm requiring vasopressor support; another 26-year-old male was admitted for Brugada syndrome-like electrocardiogram elements.…”

Section: Diagnosis Of Addison's Disease: Clinical Biochemical and Hor...mentioning

confidence: 99%

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Addison’s Disease: Diagnosis and Management Strategies

Cârșote¹,

Nistor²

2023

IJGM

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We aim to overview Addison’s disease (AD) with regard to current diagnosis and management. This is a narrative review of full-length articles published in English between January 2022 and December 2022 (including online ahead of print versions) in PubMed-indexed journals. We included original studies in living humans regardless of the level of statistical significance starting from the key search terms “Addison’s disease” or “primary adrenal insufficiency” in title or abstract. We excluded articles with secondary adrenal insufficiency. Briefly, 199 and 355 papers, respectively were identified; we manually checked each of them, excluded the duplicates, and then selected 129 based on their clinical relevance in order to address our 1-year analysis. We organized the data in different subsections covering all published aspects on the subject of AD. To our knowledge, this is the largest AD retrospective from 2022 on published data. A massive role of genetic diagnosis especially in pediatric cases is highlighted; the importance of both pediatric and adult awareness remains since unusual presentations continue to be described. COVID-19 infection is a strong player amid this third year of pandemic although we still not do have large cohorts in this particular matter as seen, for instance, in thyroid anomalies. In our opinion, the most important topic for research is immune checkpoint inhibitors, which cause a large panel of endocrine side effects, AD being one of them.

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“… 12 Another 56-year-old male was admitted for organic delusional disorder at onset of tuberculosis-associated AD. 13 …”

Section: Resultsmentioning

confidence: 99%

Section: Diagnosis Of Addison's Disease: Clinical Biochemical and Hor...mentioning

confidence: 99%

Addison’s Disease: Diagnosis and Management Strategies

Cârșote¹,

Nistor²

2023

IJGM

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“…Notwithstanding the homogeneity in symptom severity, an increased rate of relapse was seen in the patient with a history of progressively invasive tubercular adrenal involvement (Lever and Stansfeld, 1983). Tubercular involvement has also been noted in a patient who developed organic delusional disorder, with a similarly challenging symptom profile of recurrent delusions, vomiting, and giddiness (Govind et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Acute Mania and Psychosis in the Context of Primary Adrenal Insufficiency: A Systematic Review of the Literature

Ovakimyan

Patel

Brown

et al. 2023

Cognitive and Behavioral Neurology

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Background: Given the sparse nature of acute mania or psychosis in primary adrenal insufficiency (PAI), physicians may not be aware of the association of these two entities.Objective: To conduct a systematic review of the literature for the purpose of identifying all studies reporting mania and/or psychosis in individuals with PAI.Method: We conducted a systematic review according to PRIS-MA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using the PubMed, Embase, and Web of Science databases from June 22, 1970 to June 22, 2021, for the purpose of identifying all studies reporting instances of mania or psychosis associated with PAI.Results: We identified nine case reports featuring nine patients (M age = 43.3 years, male = 44.4%) over eight countries that fit our inclusion/exclusion criteria. Eight (89%) of the patients had experienced psychosis. Manic and/or psychotic symptom resolution was achieved in 100% of the cases, of which steroid replacement therapy was efficacious in seven (78%) cases and was sufficient in six (67%). Conclusion:Acute mania and psychosis in the context of PAI is a very rare presentation of an already uncommon disease. Resolution of acute psychiatric change is reliably achieved with the correction of underlying adrenal insufficiency.

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“…Delusional disorder has a later onset age than schizophrenia and does not show gender dominance [ 4 , 5 ]. The cause of delusional disorder is unknown, but genetic, biochemical, and environmental factors are thought to play an important role in its development [ 6 , 7 , 8 , 9 , 10 , 11 ]. In terms of etiopathogenesis and clinical features, delusional disorder has not been well studied compared to schizophrenia and other psychotic disorders.…”

Section: Introductionmentioning

confidence: 99%

Is the Caudate, Putamen, and Globus Pallidus the Delusional Disorder's Trio? A Texture Analysis Study

Baykara,

Baykara

2024

Actas Esp Psiquiatr

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Background: The neurobiological basis of delusional disorder is less explored through neuroimaging techniques than in other psychotic disorders. This study aims to provide information about the neural origins of delusional disorder (DD) by examining the neuroanatomical features of some basal nuclei with magnetic resonance imaging (MRI) texture analysis. Materials and Methods: Twenty DD patients and 20 healthy individuals were included in the study. Globus pallidus, putamen, and caudate nuclei were selected individually with a region of interest (ROI) on the axial MRI images. The entire texture analysis algorithm applied to all selected ROIs was done with an in-house software. Nuclei on both sides were taken as separate samples. Results: There were no significant differences between groups in terms of age and gender. The average “mean, median and maximum” values of all three nuclei were decreased in DD patients. The small putamen area and the differences detected in different tissue parameters for all three nuclei in delusional disorder patients indicate that they differ in delusional disorder from normal controls (p < 0.05). Conclusion: The differences detected in the texture parameters for all three nuclei indicate that there is something different in the DD from in the normal controls. Neuroimaging studies with larger samples and different techniques in the future may shed light on the etiology of delusional disorder.

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Diagnostic and Therapeutic Implications of Organic Delusional Disorder due to Tuberculous Adrenalitis

Cited by 4 publications

References 7 publications

Addison’s Disease: Diagnosis and Management Strategies

Addison’s Disease: Diagnosis and Management Strategies

Acute Mania and Psychosis in the Context of Primary Adrenal Insufficiency: A Systematic Review of the Literature

Is the Caudate, Putamen, and Globus Pallidus the Delusional Disorder's Trio? A Texture Analysis Study

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