Diagnostic and Therapeutic Potential of Poly(benzyl L-glutamate)

Yang, David J.; Li, Chun; Nikiforow, Sarah; Gretzer, Matthew; Kuang, Li-Ren; Lopez, Mona S.; Vargas, Karen; Wallace, Sidney

doi:10.1002/jps.2600830312

Cited by 8 publications

(4 citation statements)

References 14 publications

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“…However, the lower size limit for the embolism is somewhere between 7-12 mm [Oppenheim, 1981]. This procedure of chemoembolism has been most effective in the treatment of hypervascular hepatic neoplasms [Yang et al, 1994].…”

Section: Chemoembolism For Hepatic Neoplasmmentioning

confidence: 99%

Biopolymer albumin for diagnosis and in drug delivery

Patil¹

2003

Drug Development Research

156

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This article reviews the developmental stages and strategies used to assess the biomedical utility of biopolymer albumin from the 1970s to early 2002. The basic method and mechanism(s) of preparation of albumin microspheres and subsequent modifications made to overcome the drawbacks of earlier approaches and the need for further developments are discussed, as are the processing parameters and the level of various ingredients affecting the physicochemical properties of the albumin microspheres. Different equations proposed by various investigators to modulate in vitro release kinetics are reviewed. The microscopic structural and surface properties, the chemical modification of the biopolymer (e.g., cationization, tagging with amino acids and sugar moieties) for tissue specificity or to influence the release profile and biodegradation are discussed. An array of potential diagnostic applications and the use of albumin microspheres as a drug delivery system are reviewed. Drug Dev.

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Section: Chemoembolism For Hepatic Neoplasmmentioning

confidence: 99%

Biopolymer albumin for diagnosis and in drug delivery

Patil¹

2003

Drug Development Research

156

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“…Both dextran and PBLG are recognized for their biocompatibility, which makes them suitable candidates for drug-or gene-delivery applications. [16] Previously, we described [17] a straightforward and versatile synthesis of polypeptide-based block copolymers by an approach based on a Huisgen 1,3dipolar cycloaddition, or "click" chemistry, which combines mild experimental conditions, functional-group tolerance, and nearly quantitative yields. [18] We report herein a simple and versatile route to polysaccharide-block-polypeptide copolymers, as illustrated by the synthesis of dextran-block-PBLG (Scheme 1).…”

mentioning

confidence: 99%

Polysaccharide‐block‐polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids

Schatz¹,

Louguet²,

Meins³

et al. 2009

Angew Chem Int Ed

276

229

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Natural inspiration: Amphiphilic polysaccharide-block-polypeptide copolymers were synthesized by click chemistry from dextran end-functionalized with an alkyne group and poly(gamma-benzyl L-glutamate) end-functionalized with an azide group. The ability of these copolymers to self-assemble into small vesicles (see picture) suggests the possibility of a new generation of drug- and gene-delivery systems whose structure mimics that of viruses.

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“…Previous studies have shown that glutamate peptide is a candidate of drug carrier [ 16 , 17 ]. Radiolabeled glutamic acid has shown to be useful in tumor cellular imaging [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Development of ⁶⁸Ga‐Glycopeptide as an Imaging Probe for Tumor Angiogenesis

Tsao

Wang²,

Her³

et al. 2011

BioMed Research International

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Objective. This study was aimed to study tissue distribution and tumor imaging potential of 68Ga-glycopeptide (GP) in tumor-bearing rodents by PET. Methods. GP was synthesized by conjugating glutamate peptide and chitosan. GP was labeled with 68Ga chloride for in vitro and in vivo studies. Computer outlined region of interest (counts per pixel) of the tumor and muscle (at the symmetric site) was used to determine tumor-to-muscle count density ratios. To ascertain the feasibility of 68Ga-GP in tumor imaging in large animals, PET/CT imaging of 68Ga-GP and 18F-FDG were conducted in New Zealand white rabbits bearing VX2 tumors. Standard uptake value of tumors were determined by PET up to 45 min. To determine blood clearance and half-life of 68Ga-GP, blood samples were collected from 10 seconds to 20 min. Results. Radiochemical purity of 68Ga-GP determined by instant thin-layer chromatography was >95%. Tumor uptake values (SUV) for 68Ga-GP and 18F-FDG in New Zealand white rabbits bearing VX2 tumors were 3.25 versus 7.04. PET images in tumor-bearing rats and rabbits confirmed that 68Ga-GP could assess tumor uptake. From blood clearance curve, the half-life of 68Ga-GP was 1.84 hr. Conclusion Our data indicate that it is feasible to use 68Ga-GP to assess tumor angiogenesis.

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Diagnostic and Therapeutic Potential of Poly(benzyl L-glutamate)

Cited by 8 publications

References 14 publications

Biopolymer albumin for diagnosis and in drug delivery

Biopolymer albumin for diagnosis and in drug delivery

Polysaccharide‐block‐polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids

Development of ⁶⁸Ga‐Glycopeptide as an Imaging Probe for Tumor Angiogenesis

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Diagnostic and Therapeutic Potential of Poly(benzyl L-glutamate)

Cited by 8 publications

References 14 publications

Biopolymer albumin for diagnosis and in drug delivery

Biopolymer albumin for diagnosis and in drug delivery

Polysaccharide‐block‐polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids

Development of 68Ga‐Glycopeptide as an Imaging Probe for Tumor Angiogenesis

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Development of ⁶⁸Ga‐Glycopeptide as an Imaging Probe for Tumor Angiogenesis