2013
DOI: 10.1177/0004563213491078
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Diagnostic applications of newborn screening for α-thalassaemias, haemoglobins E and H disorders using isoelectric focusing on dry blood spots

Abstract: Background: Neonatal screening for haemoglobin (Hb) disorders is a standard of care in several developed countries with the main objective to detect Hb S. Such practice has not been established in Thailand where a-thalassaemia and haemoglobin E (Hb E) are highly prevalent. Early identification of thalassaemias could be helpful and strengthen the programme for prevention and control for severe thalassaemias. Methods: Data from isoelectric focusing (IEF) and IsoscanÕ for detecting types and amount (%) of each ha… Show more

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Cited by 16 publications
(6 citation statements)
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“…Each year, approximately 5500 severe α‐thalassemia patients die during the perinatal period, and 50 500 β‐thalassemia major patients are born throughout the entire world, which at least 30 000 require lifetime standard blood transfusions to survive 3 . Early identification of thalassemia is beneficial for timely prevention and control of thalassemia major 4 . Thalassemia gene screening and related genetic counseling are the most effective ways to reduce the incidence of thalassemia major 5 …”
Section: Introductionmentioning
confidence: 99%
“…Each year, approximately 5500 severe α‐thalassemia patients die during the perinatal period, and 50 500 β‐thalassemia major patients are born throughout the entire world, which at least 30 000 require lifetime standard blood transfusions to survive 3 . Early identification of thalassemia is beneficial for timely prevention and control of thalassemia major 4 . Thalassemia gene screening and related genetic counseling are the most effective ways to reduce the incidence of thalassemia major 5 …”
Section: Introductionmentioning
confidence: 99%
“…As the high prevalence of thalassemia and abnormal hemoglobin in Thailand, one of the possible causes of anemia in these donors is thalassemia carriers. [22][23][24] The complete blood count testing is necessary for donor screening to reject the mild anemia case and prevent IDA.…”
Section: Discussionmentioning
confidence: 99%
“…In regions with high prevalence and also in some low prevalence areas for α-thalassemia, HbH disease is included in the newborn screening program as a target disease. Technologies such as IEF, HPLC, and CE are able to detect Hb Bart's [20][21][22][23][24]. Several cut-offs were evaluated for HPLC or a qualitative detection of Hb Bart's in the fraction of fast-eluting hemoglobins (≥15% or ≥20% or ≥25% for the FAST fraction on the Bio-Rad™ nbs System, evaluated on different integration principles).…”
Section: Severe α-Thalassemia Hbh Diseasementioning
confidence: 99%