Diagnostic approach for classic Hodgkin lymphoma in small samples                    with an emphasis on PD-L1 expression and EBV harboring in tumor cells: a brief                    review from morphology to biology

Takahara, Taishi; Sakakibara, Ayako; Tsuyuki, Yuta; Satou, Akira; Kato, Seiichi; Nakamura, Shigeo

doi:10.3960/jslrt.23003

Cited by 1 publication

(1 citation statement)

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“… 19 In addition, the most frequent genetic alteration of CHL is a copy number gain of 9p24.1 at the locus that includes PD-L1/L2, constituting up to 97% of all CHL. 20 , 21 These data indicate that there may be differences in the pathogenesis of MTX-LPD in different morphologies.…”

Section: Introductionmentioning

confidence: 85%

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders

Okatani,

Nishimura,

Egusa

et al. 2024

J Clin Exp Hematopathol

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Methotrexate (MTX)-associated lymphoproliferative disorder (MTX-LPD) is a lymphoproliferative disorder in patients treated with MTX. The mechanism of pathogenesis is still elusive, but it is thought to be a complex interplay of factors, such as underlying autoimmune disease activity, MTX use, Epstein-Barr virus infection, and aging. The NOTCH genes encode receptors for a signaling pathway that regulates various fundamental cellular processes, such as proliferation and differentiation during embryonic development. Mutations of NOTCH1 have been reported in B-cell tumors, including chronic lymphocytic leukemia/lymphoma, mantle cell lymphoma, and diffuse large B-cell lymphoma (DLBCL). Recently, it has also been reported that NOTCH1 mutations are found in post-transplant lymphoproliferative disorders, and in CD20-positive cells in angioimmunoblastic T-cell lymphoma, which might be associated with lymphomagenesis in immunodeficiency. In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type ( P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this difference was not significant ( P = 0.0605). The results showed that NOTCH1 may be involved in the proliferation and tumorigenesis of B cells under the use of MTX. Further research, including genetic studies, is necessary.

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Section: Introductionmentioning

confidence: 85%