Diagnostic approach in lymphoplasmacytic plaque

Abstract

LPP is a long-standing skin disease, which may also occur in adults and in other body regions than the lower leg. Reproducible clinical and histological criteria allow delineating a diagnostic work-up for LPP.

Case of lymphoplasmacytic plaque in children: Analysis of the distribution of infiltrating immune cells

“…APACHE and LPP share similar histological findings, but LPP can be distinguished from APACHE based on the clinical findings of small reddish nodules. 5 Ultimately, we diagnosed this case as LPP. Topical corticosteroid application and ultraviolet irradiation failed to improve the lesion.…”

“…The affected sites are usually the extremities, and 10 of 16 cases have involved the lower limbs. 5 Histologically, a dense dermal lymphocytic infiltrate admixed with polyclonal plasma cells are seen. Here, we report a case of LPP with a histological analysis of the distribution of infiltrating immune cells.…”

“…In addition to the pseudolymphomatous lymphoplasmacytic infiltrate, a lichenoid tissue reaction is a crucial histological finding that has been noted in 11 cases, including our case. 5 To gain insight into the pathogenic immune cells of this eruption, the distribution of the infiltrating cells was analyzed. Interestingly, we found that each immune cell population had a preferential distribution in the dermis (Fig.…”

A case of lymphoplasmacytic plaque in children

“…Primary cutaneous plasma cell infiltrates are rare in children and are mostly reactional, in response to infection. A recently recognized entity has been described under the name of ‘lymphoplasmacytic plaque in children’ or ‘isolated benign primary cutaneous plasmacytosis in children’ or ‘pretibial lymphoplasmacytic plaque’ . They have characteristic clinical and histopathological features and no systemic manifestations.…”

“…Lymphoplasmacytic plaque in children is a recently recognized entity, also reported under the name of isolated benign primary cutaneous plasmacytosis in children or pretibial lymphoplasmacytic plaque. Less than 20 cases have been reported so far . The clinical presentation is very distinctive with isolated reddish brown to violaceous well‐defined plaques with small papules, sometimes scaling, appearing in children from age 7–15.…”