Diagnostic Biomarkers for Oral and Periodontal Diseases

Abstract

This article provides an overview of periodontal disease diagnosis that uses clinical parameters and biomarkers of the disease process.This article discusses the use of biomarkers of disease that can be identified at the tissue, cellular, and molecular levels and that are measurable in oral fluids such as saliva and gingival crevicular fluid. Biomarkers identified from these biologic fluids include microbial, host response, and connective tissue-related molecules that can target specific pathways of local alveolar bone resorption. Future prospects for oral fluid-based diagnostics that use micro-array and microfluidic technologies are presented.

Microbiology of Periodontal Diseases. A Review

“…These bacterial strains are defined as periodontal pathogens (16,24). In the last three decades, it has been generally accepted that periodontal infections are polymicrobial (1,5,27). only a small percentage of the dental biofilm bacteria are defined as pathogenic for the periodontal tissues.…”

Biomarkers: A Critical Update

“…Professionals in seemingly unrelated arenas such as the insurance industry, the Environment Protection Agency, and Homeland Security are interested in the possible use of oral fluids to monitor biomarkers. Under investigation are possible uses of GCF and saliva in the preliminary screening for biological/chemical warfare agent exposure, environmental toxin detection, and screening for metabolites of drugs of abuse (5).…”

The Effect Of İnitial Periodontal Therapy On Saliva And Plasma Total Antioxidant Capacity Of Non-Smoking Periodontitis Patients

“…Günümüzde plazma enflamasyon varlığında artan veya azalan spesifik biyobelirteçlerin periodontal hastalık ile ilişkisini araştırmak için kullanılmaktadır. 5 Periodontitisli bireylerin plazmalarının incelendiği araştırmalarda periodontal hastalığın, sistemik enflamasyon üzerine etkisinin olabileceği sonucuna varılmış, fakat bu sonuç kesinlik kazanmamıştır.…”