Diagnostic capability of fine‐needle aspiration cytology in assessment of intraosseous lesions of the jaws: A systematic review

Abstract

Purpose To systematically review (SR) and critically appraise studies that investigated the diagnostic capability of fine‐needle aspiration cytology (FNAC) in the assessment of intraosseous lesions of the jaws. Methods Six main electronic databases and three gray literature databases were searched aiming diagnostic studies, which were selected in a two‐phase process. Risk of bias (RoB) of included studies was assessed using the Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies. Results A total of eight articles were included, of which six evaluated the FNAC smear technique exclusively, one assessed both smear and cell‐block techniques, while one investigated only the cell‐block technique. With regard to the FNAC smear technique, from 134 benign lesions investigated, concordance with the histopathological diagnosis was achieved in 64.17% of cases. In addition, considering the 32 malignant lesions assessed through this technique, concordance with histopathology was achieved in all cases. Regarding the cell‐block technique, only benign lesions (n = 40) were evaluated in the included studies, in which the concordance rate with histopathology was of 77.5%. The overall RoB judgment was “at risk of bias” for seven included studies mostly due to lack of information or reportedly absence of blinding of evaluator. Conclusions Within the limitations of this SR, FNAC presented modest to satisfactory diagnostic capability for the assessment of intraosseous jaw lesions, showing concordance rates higher than 64% for the smear and 77% for the cell‐block technique. Also, considerably high concordance rates were found for the assessment of malignant lesions regarding FNAC smear technique.

Fine‐needle aspiration cytology for the diagnosis of plasma cell neoplasms in the head and neck region: A systematic analysis of the literature

“…Current clinical practice guidelines recommend FNAC for the diagnostic investigation of breast and thyroid nodules, suspicious lymph nodes, and deep‐seated mass lesions 12–15 . A recent systematic review identified concordance rates higher than 64% for the smear and 77% for the cell‐block technique regarding diagnostic capability for the evaluation of intraosseous jaw lesions, including malignant lesions 16 . Despite several published reports on the cytopathological diagnosis of PCN, either in isolated manifestations (extramedullary or solitary bone plasmacytoma) or as a consequence of PCM, 17–98 there is a lack of compiled information investigating the agreement of cytopathological and histopathological findings, along with others ancillary cytological methods such as smears and cell blocks.…”

Cytomorphological Characteristics Of Ameloblastoma By Fine Needle Aspiration Biopsy Procedure Confirmed With Histopathological Examination

“…The FNAB technique is quite simple, minimally invasive with a low complication that allows rapid diagnosis, and can differentiate benign and malignant lesions with a high degree of accuracy when correlated with clinical and radiographic findings. The information obtained from the FNAB procedure is useful as a guide for surgical planning, especially in large lesions and patients with systemic disorders (Pilati et al, 2020).…”