Diagnostic Capability of Optical Coherence Tomography in Evaluating the Degree of Glaucomatous Retinal Nerve Fiber Damage

Sihota, Ramanjit; Sony, Parul; Gupta, Viney; Dada, Tanuj; Singh, Rajvir

doi:10.1167/iovs.05-1102

Cited by 205 publications

(143 citation statements)

References 19 publications

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“…In the fellow eyes, no significant difference in RNFL measurement was found except the temporal quadrant when compared with the controls. This result is comparable with our study Sihota et al (5) evaluated the role of (OCT) in detecting differences in peripapillary RNFL thickness among normal and glaucomatous eyes and also among different severities of glaucoma. The average RNFL in control subjects, early glaucoma, moderate glaucoma, severe glaucoma, and blind glaucoma were 102.30 plus/minus 10.34, 77.68 plus/minus 15.7, 66.07 plus/minus 15.5, 53.65 plus/minus 14.2, and 44.93 plus/minus 4.95 micron, respectively.…”

Section: Discussionsupporting

confidence: 93%

Analysis of Retinal Nerve Fiber Layer Thickness in Patients with Pseudoexfoliation Syndrome Using Spectral Domain Optical Coherence Tomography

2015

IJSR

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Aim: To detect early glaucomatous damage in PXS with normal IOP, visual field and optic nerve head appearance by assessing the RNFL thickness using SD-OCT. Design: prospective observational study. Methods: The study was carried out on 40 eyes; 20 non-glaucomatous eyes with PXS (group A) and 20 normal control subjects (group B). After informed consent was signed and BCVA, participants underwent slit lamp biomicroscopy, Goldmann applanation tonometry, gonioscopy, ophthalmoscopy, automated refraction and Humphrey (central 24-2 threshold) visual field. Results: In our study we demonstrated the mean overall RNFL thickness in both groups and we found it was lower in group A than B. Conclusion: Pseudo-exfoliation syndrome without glaucoma may be associated with a thinner RNFL compared with those of control subjects so even small rise in IOP causes damage to the RNFL. Thus we can say that structural damage preceeds functional loss and that early RNFL thickness assessment using OCT is important in the early diagnosis, intervention and follow-up of pseudo exfoliation glaucoma.

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Section: Discussionsupporting

confidence: 93%

Analysis of Retinal Nerve Fiber Layer Thickness in Patients with Pseudoexfoliation Syndrome Using Spectral Domain Optical Coherence Tomography

2015

IJSR

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“…A negative correlation was seen between the two and it was significant (r value > 0.5), which means as the severity of glaucoma increases there is a progressive decline in average RNFL thickness. Similar results were found in C. Ajtony et al 9 study and Sihota et al 13 study, but not that of Sujatha Subbaiah et al 7 study which showed a positive correlation between MD and average RNFL thickness (Table no. 2).…”

Section: Correlation Between MD and Average Rnfl Thickness And Comparsupporting

confidence: 80%

A Study of Correlation of Visual Field Changes by Humphrey’s Automated Field Analyser With Retinal Nerve Fiber Layer (Rnfl) Defects on Optical Coherence Tomography (Oct) in Primary Open Angle Glaucoma (Poag)

Pasumarthy¹,

Kumar²,

Syamala³

2017

jemds

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BACKGROUNDGlaucoma is a significant global health problem. Glaucoma is second only to cataract as a cause of blindness worldwide. As of the year 2000, 67 million people worldwide were affected with "primary" glaucoma. Of these patients, 6.7 million were bilaterally blind. 1 According to various studies, the prevalence of glaucoma in India ranges from 2.6% to 4.15%. 2 It is estimated that there will be 60.5 million people with OAG and ACG in 2010, increasing to 79.6 million by 2020, and of these 74% will have OAG.The aim of the study was to correlate the RNFL changes with visual field defects in Primary Open Angle Glaucoma (POAG).

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“…Previous studies [11][12][13][14][15][16] have reported the sensitivity and specificity of OCT for discriminating between healthy and glaucomatous eyes. Very few studies, [17][18][19][20][21] however, have attempted to increase the diagnostic ability of OCT using learning classifiers.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic ability of a linear discriminant function for optic nerve head parameters measured with optical coherence tomography for perimetric glaucoma

Pablo

Ferreras

Pajarín³

et al. 2009

Eye

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Background/aims To calculate and validate a linear discriminant function (LDF) for optical coherence tomography (OCT) to improve the diagnostic ability of isolated optic nerve head (ONH) parameters to discriminate between healthy individuals and glaucoma patients. Methods Two independent samples (teaching and validating sets) were prospectively selected. The teaching set (54 normal eyes and 73 glaucoma patients) was used to calculate the LDF. The validating set (70 healthy individuals and 67 glaucoma patients) was used to test the performance of the LDF in an independent population. Receiver operating characteristic (ROC) curves were plotted and compared with the ONH parameters measured using OCT. Results The optimized function was: LDF ¼ 8.204 þ (2.59 Â disc area)-(9.25 Â horizontal rim width). The largest areas under the ROC curve were 0.923 and 0.898 for our LDF and the vertical rim area in the validating population respectively. There were no significant differences between the areas. At 95% fixed specificity, the LDF (71.64%) and the vertical rim area (65.67%) yielded the highest sensitivity values. Conclusions All ONH parameters obtained with OCT, except disc area, had a good ability to differentiate between healthy and glaucoma individuals. As judged by the area under the ROC curve, the LDF performed better than any single parameter, although statistics did not prove it better than vertical cup/disc ratio or

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Diagnostic Capability of Optical Coherence Tomography in Evaluating the Degree of Glaucomatous Retinal Nerve Fiber Damage

Cited by 205 publications

References 19 publications

Analysis of Retinal Nerve Fiber Layer Thickness in Patients with Pseudoexfoliation Syndrome Using Spectral Domain Optical Coherence Tomography

Analysis of Retinal Nerve Fiber Layer Thickness in Patients with Pseudoexfoliation Syndrome Using Spectral Domain Optical Coherence Tomography

A Study of Correlation of Visual Field Changes by Humphrey’s Automated Field Analyser With Retinal Nerve Fiber Layer (Rnfl) Defects on Optical Coherence Tomography (Oct) in Primary Open Angle Glaucoma (Poag)

Diagnostic ability of a linear discriminant function for optic nerve head parameters measured with optical coherence tomography for perimetric glaucoma

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