Diagnostic criteria for left ventricular non-compaction in cardiac computed tomography

Fuchs, Tobias A.; Erhart, Ladina; Ghadri, Jelena R.; Herzog, Bernhard A.; Giannopoulos, Andreas A.; Buechel, Ronny R.; Stämpfli, Simon F.; Gruner, Christiane; Pazhenkottil, Aju P.; Niemann, Markus; Kaufmann, Philipp A.; Tanner, Felix C.

doi:10.1371/journal.pone.0235751

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…on transthoracic echocardiography [13] and MRI which is the second modality, with an excellent spatial resolution, is the best method because it has not only a diagnostic but also a prognostic role" [14]. "LVNC can be diagnosed with ECG-triggered low-dose CCT (cardiac computed tomography) with a very good correlation of NC:C ratio in TTE and CCT" [15]. Our patient was diagnosed and confirmed with coupled TTEcardiac MRI.…”

Section: Discussionmentioning

confidence: 55%

A Young Healthy Woman with Supraventricular Tachycardia Reveals an Underlying Left Ventricular Non-compaction Cardiomyopathy: A Rare Case Report

Tahir

Mulendelé²,

Foudail³

et al. 2023

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LVNC (left ventricular non-compaction) is a rare congenital cardiomyopathy with a reported incidence of 0.05% in adults. It can occur in isolation or affect both ventricles. It’s characterized by prominent LV trabeculae and deep intertrabecular recesses which are filled with blood from the ventricular cavity without evidence of communication to the epicardial coronary artery system. Frequent premature supra ventricular tachycardia as unique finding in LVNC cardiomyopathy is rare manifestation of this disease. We report a case of a frequent persistent supraventricular tachycardia as first manifestation of a patient with LVNC cardiomyopathy in a young healthy woman who despite radio frequency ablation therapy of the supraventricular tachycardia remains symptomatic. The patient was later placed on medical therapy based on a non-cardio selective beta-blocker with a good clinical outcome without recurrent of supra-ventricular arrythmias.

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Section: Discussionmentioning

confidence: 55%

A Young Healthy Woman with Supraventricular Tachycardia Reveals an Underlying Left Ventricular Non-compaction Cardiomyopathy: A Rare Case Report

Tahir

Mulendelé²,

Foudail³

et al. 2023

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“…Fuchs et al analyzed ECG-triggered low-dose cardiac CT and could discriminate patients with NCCM from normal individuals by using an NC:C ratio of >1.8 in diastole. Their results showed a good correlation of NC:C ratio between transthoracic echocardiography (TTE) and cardiac CT with the threshold of 1.8 [ 97 ].…”

Section: Additional Diagnostic Armamentariummentioning

confidence: 99%

Noncompaction Cardiomyopathy—History and Current Knowledge for Clinical Practice

Gerecke

Engberding

2021

JCM

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Noncompaction cardiomyopathy (NCCM) has gained increasing attention over the past twenty years, but in daily clinical practice NCCM is still rarely considered. So far, there are no generally accepted diagnostic criteria and some groups even refuse to acknowledge it as a distinct cardiomyopathy, and grade it as a variant of dilated cardiomyopathy or a morphological trait of different conditions. A wide range of morphological variants have been observed even in healthy persons, suggesting that pathologic remodeling and physiologic adaptation have to be differentiated in cases where this spongy myocardial pattern is encountered. Recent studies have uncovered numerous new pathogenetic and pathophysiologic aspects of this elusive cardiomyopathy, but a current summary and evaluation of clinical patient management are still lacking, especially to avoid mis- and overdiagnosis. Addressing this issue, this article provides an up to date overview of the current knowledge in classification, pathogenesis, pathophysiology, epidemiology, clinical manifestations and diagnostic evaluation, including genetic testing, treatment and prognosis of NCCM.

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“…Non-compact myocardium is diagnosed based on the results of cardiac imaging tests. Several methods can be used for diagnosis: transthoracic echocardiography, cardiac magnetic resonance imaging (CMR), and, less commonly, cardiac computed tomography [20,21]. Although there is no unanimously accepted non-compaction diagnostic gold standard, one of the main criteria used in the clinical practice are the echocardiographic criteria described by Jenni et al in 2001: the ratio of non-compact to compact myocardial layers (NCM:CM) is greater than 2 at the end of systole, the non-compaction of myocardium is expressed in the localizations typical for this pathology, the colour Doppler method shows blood flow in the intertrabecular pockets, and no concomitant cardiac disorders are found in the patient [22,23].…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance diagnostic criteria of non-compaction cardiomyopathy: new diagnostic criteria still needed?

Gaižauskienė

Glembockytė

Glaveckaitė

et al. 2023

Seminars in Cardiovascular Medicine

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Summary Non-compaction cardiomyopathy (NCC) is a rare pathology, but the exact rates of its prevalence are not known due to the lack of a diagnostic gold standard. The purpose of this article is to analyse the available cardiovascular magnetic resonance (CMR) diagnostic criteria of non-compaction described in the literature and to compare their sensitivity and specificity in the diagnosis of NCC. A search of available literature related to the CMR diagnostic criteria of myocardial non-compaction was conducted in the medical database PubMed in February of 2022. The period of publication of scientific articles covered the years from 1996 to 2022. A total of 7 full-text scientific articles were included in the final literature review. The main diagnostic criteria were used: the maximum non-compact (NCM) to compact myocardial layers (CM) ratio (NCM:CM), the percentage of trabeculated left ventricular (LV) myocardial mass, the percentage of trabeculated LV myocardial volume, the non-compact myocardial mass index of the total LV, and the determination of the total LV and the maximal fractal dimension (FD) of the apex with the use of fractal analysis. The lack of accurate diagnostic criteria results in an overdiagnosis of NCC. The highest sensitivity and specificity are associated with the maximum FD > 1.30 of the apex established by applying the fractal analysis method. Fractal analysis requires dedicated software, and this method is difficult to apply in routine clinical practice. Thus, the diagnostic criteria for the NCC using magnetic resonance imaging with higher diagnostic value remain to be sought.

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Diagnostic criteria for left ventricular non-compaction in cardiac computed tomography

Cited by 11 publications

References 32 publications

A Young Healthy Woman with Supraventricular Tachycardia Reveals an Underlying Left Ventricular Non-compaction Cardiomyopathy: A Rare Case Report

A Young Healthy Woman with Supraventricular Tachycardia Reveals an Underlying Left Ventricular Non-compaction Cardiomyopathy: A Rare Case Report

Noncompaction Cardiomyopathy—History and Current Knowledge for Clinical Practice

Magnetic resonance diagnostic criteria of non-compaction cardiomyopathy: new diagnostic criteria still needed?

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