Diagnostic cutoff points for 123I-MIBG myocardial scintigraphy in a Caucasian population with Parkinson’s disease

Abstract

The diagnostic cutoff point for (123)I-MIBG myocardial scintigraphy in a Caucasian population with PD was 1.43 for the H/M4h index, with a good sensitivity and specificity. The technique is easy to use, with a good reproducibility over a range of interpretation expertise.

MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis

“…In fact, it has been demonstrated that H/M values may decrease with aging, and females usually show significantly higher H/M values than males of the same age [46]. Moreover, the H/M threshold value for a Caucasian population differs from that of a Japanese population, as recently demonstrated by Muxí et al [49], who found in their Caucasian population a H/M threshold value of 1.43, lower than that for a Japanese population [4].…”

Assessment of global cardiac I-123 MIBG uptake and washout using volumetric quantification of SPECT acquisitions

“…Information on the distribution of neurons and function of the (re-)uptake-1 pathway is provided by the heart-to-mediastinum (HM) ratio, while the washout rate (WOR) provides information on the sympathetic drive. Both indices are commonly applied in I-123 MIBG imaging and the inter- and intraobserver variability of the HM ratio are considered low 6,7…”

Response to Montgomery/Turkstra Re: Rational therapy: Defense against evidence based medicine (EBM)

“…5 Moreover, the H/M threshold value for a white population differs from that of a Japanese population. 6,7 Therefore, caution should be exercised when applying an ''ideal'' H/M threshold value to individual centers. 8 Every single nuclear medicine unit should use its own H/M threshold value, based on its own normal controls; this H/M threshold value is usually obtained by computing the 95th percentile of results in normal controls 9 matched for age, sex, and race.…”