Introduction Peroneal neuropathy is one of the most common mononeuropathies in the lower extremities and usually occurs at the fibular head where the nerve is superficial and vulnerable to injury. Peroneal neuropathy at the fibular head (PNFH) can result from a variety of conditions such as trauma, traction injuries, masses, entrapment, and external compression from prolonged immobilization. Patients with PNFH usually have weak toe and ankle dorsiflexion, weak foot eversion, and numbness over the lower lateral calf and the dorsum of the foot. Therefore, patients with sciatic neuropathy, lumbosacral plexopathy, or L5 radiculopathy may present a similar clinical pattern and differentiating PNFH from these conditions may sometimes be difficult (1,2). The diagnosis of PNFH is based on clinical findings and electrophysiological studies. Electrophysiological evaluation is usually adequate for the diagnosis of PNFH. However, additional tests may be required, especially in nonlocalizing peroneal nerve lesions with severe axonal loss. Although ultrasonography has proven to be useful in entrapment neuropathies of the upper extremities (3,4), there are few studies that investigated the validity of ultrasonography in the diagnosis of PNFH (5-8). In this study, we analyzed ultrasonographic findings in patients with PNFH and evaluated the efficiency of ultrasonography in the diagnosis of PNFH. 2. Materials and methods 2.1. Patients and controls This study included 15 peroneal nerves of 12 patients with PNFH and 24 peroneal nerves of 12 healthy controls. Three patients had PNFH bilaterally. The inclusion criteria were based on both clinical and electrophysiological findings. To make the clinical diagnosis, we looked for weak toe and ankle dorsiflexion, weak foot eversion, and sensory loss over the lateral calf and the dorsum of the foot. Local pain or Tinel's sign may also be present at the fibular head. Patients with any symptoms of polyneuropathy were excluded from the study. Patients with diseases related to polyneuropathy, hypothyroidism, diabetes mellitus, amyloidosis rheumatoid arthritis, or pregnancy were also excluded from the study. Histories of acute trauma, peroneal surgery, and duration of symptoms longer than Background/aim: Peroneal neuropathy at the fibular head (PNFH) is one of the most common entrapment neuropathies. Our aim in this study was to analyze the efficiency of ultrasonography in the diagnosis of PNFH. Materials and methods: The study included 15 peroneal nerves of 12 patients with PNFH and 24 peroneal nerves of 12 healthy controls. PNFH confirmation was based on clinical and electrophysiological findings. All patients and controls underwent ultrasonographic evaluations for peroneal nerves. The cross-sectional area (CSA) was measured. Echogenicity of the nerve was evaluated by comparing it with the adjacent connective tissue deep under the subcutaneous fat. Results: CSA measurement of the peroneal nerve is a valuable diagnostic tool in predicting PNFH (AUC: 0.87, 95% CI: 0.73-1.00, P < 0.01). The CSA ...