Diagnostic des infections spontanées du liquide d’ascite chez le cirrhotique par bandelette urinaire

Wisniewski, B; Rautou, Pierre‐Emmanuel; Sirafi, Y. Al; Lambare-Narcy, B.; Drouhin, F; Constantini, D.; Fischer, Daniel A.; Labayle, D; Denis, Jacques

doi:10.1016/s0755-4982(05)84098-9

Cited by 19 publications

(4 citation statements)

References 15 publications

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“…Tumor necrosis factor-α [13,16,17] Interleukin-6 [13,16,17] Lactoferrin [4,19,20] Calprotectin [13,18,35] Leukocyte esterase reagent strips [4,5,10,[36][37][38][39][40][41][42][43][44][45][46][47][48] Macrophage inflammatory protein type 1 β [21] Interferon-γ-induced protein 10 kDa [16] Triggering receptor expressed on myeloid cells 1 [51] High-sensitivity CRP [53]…”

Section: Ascitic Fluidmentioning

confidence: 99%

“…In the past two decades, several studies have examined the usefulness of leukocyte esterase reagent strips for the diagnosis of SBP. Oey et al [38] summarized 23 studies published from 2002 to 2015 and concluded that the accuracy of the strips for the diagnosis of SBP varied, with a sensitivity of 45% [41] to 100% [38,42], a specificity of 90% to 100% [43], a positive predictive value of 42% [44] to 100% [43], and a negative predictive value of 93% [45] to 100% [38,42]. Thus, leukocyte esterase reagent strips have poor sensitivity and poor positive predictive value [4,37,38].…”

Section: Leukocyte Esterase Reagent Stripsmentioning

confidence: 99%

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Diagnostic Laboratory Markers for Spontaneous Bacterial Peritonitis

Shizuma¹

2016

Ann Clin Lab Res

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Spontaneous bacterial peritonitis (SBP) is an often-lifethreatening bacterial infection in patients with liver cirrhosis with ascites. Useful laboratory methods for early diagnosis are essential. The gold standard method for the diagnosis of SBP is a polymorphonuclear leukocyte (PMN) count of ≥250 cells/mm 3 in the ascitic fluid. Some studies have investigated the usefulness of other novel laboratory methods for the diagnosis of SBP. This paper reviews studies of diagnostic markers for SBP, such as procalcitonin, calprotectin, and leukocyte esterase reagent strips in ascitic fluid. At present, serum procalcitonin is a relatively sensitive and specific marker for the diagnosis of SBP. The usefulness of ascitic levels of procalcitonin and calprotectin for differentiating between SBP and sterile ascites is still uncertain because of the small number of studies. Although the sensitivity of leukocyte esterase reagent strips for diagnosing SBP is variable, a negative test result may predict absence of SBP.

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Section: Ascitic Fluidmentioning

confidence: 99%

Section: Leukocyte Esterase Reagent Stripsmentioning

confidence: 99%

Diagnostic Laboratory Markers for Spontaneous Bacterial Peritonitis

Shizuma¹

2016

Ann Clin Lab Res

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“…Leukocyte esterase enzyme has been shown as an important marker for PMN cell activity (3,9) . The efficacy of LER test for diagnosis of SBP has been reported in previous studies (4,13,18,26,28,29) . Leukocyte esterase was used for urine analysis first, but recently it has been found to be useful across a wide range of body fluid infections (2,17) .…”

Section: Discussionmentioning

confidence: 61%

Evaluation of Leukocyte Esterase Reagent Strips Test in the Diagnosis of Spontaneous Bacterial Peritonitis in Children With Cirrhosis

Honar

Geramizadeh

Dehghani

et al. 2015

Arq. Gastroenterol.

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“…The sensitivity of urinary reagent strips in these studies for the diagnosis of SBP has ranged between 85% and 100%, and the specificity between 98% and 100%. [ 30 31 32 33 34 35 36 37 ] In India, till date only two studies have been published on the use of LERS in AF. They reported the sensitivity and specificity as follows: Jha et al .…”

Section: Discussionmentioning

confidence: 99%

Diagnosing bacterial peritonitis made easy by use of leukocyte esterase dipsticks

Chugh

Agrawal

Goyal

et al. 2015

Int J Crit Illn Inj Sci

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Introduction:Spontaneous bacterial peritonitis (SBP) requires rapid diagnosis for the initiation of antibiotics. Its diagnosis is usually based on manual examination of ascitic fluid (AF) having long reporting time. AF infection is diagnosed when the fluid polymorphonuclear leukocyte (PMNL) concentration ≥250 cells/mm3.Aims and Objectives:Aim was to evaluate the diagnostic utility of leukocyte esterase (LE) reagent strip for rapid diagnosis of SBP in patients who underwent abdominal paracentesis and to calculate the sensitivity, specificity, positive, and negative predictive values.Materials and Methods:The study was carried out on 103 patients with ascites. Cell count of AF as determined by colorimetric scale of Multistix 10 SG reagent strip was compared with counting chamber method (PMNL count ≥250 cells/mm3 was considered positive).Results and Observations:Of the 103 patients SBP was diagnosed in 20 patients, 83 patients were negative for SBP by manual cell count. The sensitivity and specificity of the LE test for detecting neutrocytic SBP taking grade 2 as cut off were 95% and 96.4% respectively, with a positive predictive value of 86.4% and a negative predictive value of 98.8%. Diagnostic accuracy of LE test was 96.1%.Discussion:There was a good correlation between the reagent strip result and PMNL count. The LE strip test is based on the esterase activity of activated granulocytes which reacts with an ester-releasing hydroxyphenylpyrrole causing a colour change in the azo dye of reagent strip. It is a very sensitive and specific method for the prompt detection of elevated PMNL count, and represents a convenient, inexpensive, simple, and bedside method for diagnosis of SBP. A negative LE test result excludes SBP with a high degree of certainty.

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Diagnostic des infections spontanées du liquide d’ascite chez le cirrhotique par bandelette urinaire

Cited by 19 publications

References 15 publications

Diagnostic Laboratory Markers for Spontaneous Bacterial Peritonitis

Diagnostic Laboratory Markers for Spontaneous Bacterial Peritonitis

Evaluation of Leukocyte Esterase Reagent Strips Test in the Diagnosis of Spontaneous Bacterial Peritonitis in Children With Cirrhosis

Diagnosing bacterial peritonitis made easy by use of leukocyte esterase dipsticks

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