Diagnostic des retards pubertaires

Busiah, Kanetee; Bélien, Valérie; Dallot, N.; Fila, Marc; Guilbert, J.; Harroche, Annie; Léger, Juliane

doi:10.1016/j.arcped.2007.05.012

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Weight and height were recorded, and individual body mass index (BMI) was calculated (weight, kg/height, m 2 ) both for patients and for controls and evaluated 23. Assessment of puberty in adolescent patients was done according to sexual maturity rating and cases of delayed puberty are identified as regards absence of breast development in girls more than 13 years old or testicular volume less than 4 ml in boys older than 14 years old 24. Complete general physical, systemic and neurological examination was conducted.…”

Section: Methodsmentioning

confidence: 99%

<p>Vitamin D receptor rs7975232, rs731236 and rs1544410 single nucleotide polymorphisms, and 25-hydroxyvitamin D levels in Egyptian children with type 1 diabetes mellitus: effect of vitamin D co-therapy</p>

Ahmed¹,

Sakhr²,

Hassan³

et al. 2019

DMSO

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Purpose: We aimed to examine the possible association role of vitamin D and vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) in type 1 diabetes mellitus (T1DM) development, glycemic control and complications among a cohort of Egyptian children. Subjects and methods: A prospective case-control study has been conducted on 50 Egyptian children with T1DM who were comparable with 50 controls. Vitamin D and HbA1c were measured. VDR-SNPs [ Apa I (rs7975232), Taq I (rs731236) and Bsm I (rs1544410)] detection was done by polymerase chain reaction through restriction fragment length polymorphism (PCR-RFLP) technique. Vitamin D supplements were given to the included T1DM children with low vitamin D and reassessments of both HbA1c% and 25(OH)D serum levels were performed in those children three months later. Results: Eighty percent of the included diabetic patients have poor glycemic control. Vitamin D was deficient in 68% and insufficient in 16% of diabetic patients. Significant improvements in both vitamin D and glycemic status among T1DM children, who have low vitamin D and received vitamin D supplementations. There were significantly negative correlations between serum levels of vitamin D with both HbA1c % (r= –0.358, P ˂0.05) and daily insulin dose (r=−0.473, P ˂0.05). Compared with controls, T1DM children presented more commonly with Apa I a allele (OR: 2.87; 95%CI: 1.39–5.91, P ˂0.05) and Bsm I b allele (OR: 4.38; 95%CI: 2.30–8.33, P ˂0.05). Taq I t allele wasn’t significantly differing among patients and controls ( P ˃0.05). Aa+aa and Bb+bb genotypes were significantly higher among T1DM vs the controls (OR: 3.08;, 95%CI: 1.33–7.15, P ˂0.05 and OR: 9.33; 95%CI: 3.61–24.17, P ˂0.05respectively). Conclusion: Apa I and Bsm I were associated with risk of T1DM development among Egyptian children. Low vitamin D status was frequently occurring among T1DM with significant improvement in the glycemic control of such children when adding vitamin D supplements to the standard insulin therapy.

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Section: Methodsmentioning

confidence: 99%

<p>Vitamin D receptor rs7975232, rs731236 and rs1544410 single nucleotide polymorphisms, and 25-hydroxyvitamin D levels in Egyptian children with type 1 diabetes mellitus: effect of vitamin D co-therapy</p>

Ahmed¹,

Sakhr²,

Hassan³

et al. 2019

DMSO

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“…Pubertal development represents a physical, biological and psychological process, which results in the acquisition of reproductive capacities [1]. Abnormalities of pubertal development constitute a frequent reason for consultation [2]. Pubertal development is regulated by activating and inhibitory factors.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Pubertal Delay in Adolescents with Homozygous Sickle Cell Disease and Socio-Demographic, Clinical Factors

Mbamognoua,

Edzan,

Mawa

et al. 2023

OJEMD

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Introduction: Pubertal development is a process leading to the acquisition of reproductive capacities. Among the factors that inhibit pubertal development are chronic diseases including sickle cell anemia, which is a public health problem. Objectives: Describe the sociodemographic and clinical characteristics of adolescents with sickle cell disease. Report the prevalence of abnormalities of pubertal development. Identify associated factors that delay pubertal development. Patients and Methods: This was a multicenter analytical cross-sectional study over 7 months at the National Reference Center for Sickle Cell Disease and, at the Brazzaville University Hospital. It concerned adolescents with sickle cell disease aged between 10 to 19 years. The study focused on the sociodemographic characteristics of adolescents, the natural history of sickle cell anemia and the evaluation of secondary sexual characteristics using the Tanner classification. Nutritional status was assessed by calculating body mass index (BMI) and height/age and weight/age ratios. Results: Of the 347 adolescents included, the average age of the adolescents was 15.1 ± 2.5 years, 56.5% had normal puberty, 42.6% had delayed puberty and 0.9% had impuberty. The associated factors were under-nutrition with less than 3 meals/day (p = 0.0000), social status with more marked pubertal delay in orphans (p = 0.00127), more than 5 hospitalizations per year (p = 0.0013), pubertal delay was statistically significant in adolescents who had more than 3 vaso-occlusive crises (p = 0.0000), and those who had more than 5 blood How to cite this paper: Mbamognoua,

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Hypogonadisme hypergonadotrophique et galactosémie congénitale

Odièvre

Labrune

2008

Archives de Pédiatrie

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Diagnostic des retards pubertaires

Cited by 5 publications

References 28 publications

<p>Vitamin D receptor rs7975232, rs731236 and rs1544410 single nucleotide polymorphisms, and 25-hydroxyvitamin D levels in Egyptian children with type 1 diabetes mellitus: effect of vitamin D co-therapy</p>

<p>Vitamin D receptor rs7975232, rs731236 and rs1544410 single nucleotide polymorphisms, and 25-hydroxyvitamin D levels in Egyptian children with type 1 diabetes mellitus: effect of vitamin D co-therapy</p>

Correlation between Pubertal Delay in Adolescents with Homozygous Sickle Cell Disease and Socio-Demographic, Clinical Factors

Hypogonadisme hypergonadotrophique et galactosémie congénitale

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