Diagnostic efficacy and influence factors of urinary protein/creatinine ratio replacing 24-h urine protein as an evaluator of proteinuria in children

Zhai, Panpan; Huang, Yanjie; Yue, Shangsai; Yang, Xiaoqing; Luo, Jinghui; Zhang, Yanan; Mei, Xiaofeng; Bi, Liangliang; Zhai, Wei; Ren, Xianqing; Yang, Yong; Zheng, Xiaoke; Yamamoto, Tatsuo

doi:10.1007/s11255-021-03021-3

Cited by 2 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high correlation between UPCR and 24-h UP is evident in other nephropathies. In pediatric patients with proteinuria due to IgA vasculitis-associated nephritis (IgAVN), lupus nephritis, or primary NS, UPCR and 24-h UP were strongly correlated ( r = 0.869) [ 52 ]. In adults with IgAN, UPCR and 24-h UP were also strongly correlated ( r = 0.847, p < 0.001) [ 40 ], as well as in hepatocellular carcinoma patients with lenvatinib-associated proteinuria ( r = 0.86) [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study investigating amyloid light-chain amyloidosis reported a moderate correlation between UPCR and 24-h UP in patients with proteinuria levels of 500–3,000 mg/day ( r = 0.57) or > 3000 mg/day ( r = 0.62) but a strong correlation in lower levels of proteinuria (< 500 mg/day, r = 0.75) [ 54 ]. Different correlation strengths with different proteinuria levels have been demonstrated in pediatric glomerulonephritis, with a stronger correlation in non-nephrotic-range proteinuria ( r = 0.806) and a moderate correlation in nephrotic-range proteinuria ( r = 0.586) [ 52 ]. The stronger UPCR and 24-h UP correlation in the current study may be caused by the lower range of proteinuria in our participants.…”

Section: Discussionmentioning

confidence: 99%

“…Zhai et al. reported that UPCR had a sensitivity of 89.9% and specificity of 92.2% for diagnosing nephrotic-range proteinuria [ 52 ]. We analyzed the optimal diagnostic boundary to determine remission or relapse using ROC curves ( Figures 2 and 3 ).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of three spot proteinuria measurements for pediatric nephrotic syndrome: based on the International pediatric Nephrology Association 2022 Guidelines

Ambarsari,

Utami,

Tandri

et al. 2023

Renal Failure

View full text Add to dashboard Cite

Background Pediatric nephrotic syndrome (NS) requires routine proteinuria monitoring, which is costly and affects patients’ quality of life. The gold-standard 24-h urine protein (UP) measurement is challenging in children, and first-morning urine collection requires specific conditions, making it difficult in outpatient settings. Studies have reported comparability of second or random morning urine sample to the first-morning specimen. This study aimed to compare outcomes of random morning proteinuria measurements to 24-h UP and the roles of the urinary protein creatinine ratio (UPCR) and dipstick tests in pediatric NS, based on International Pediatric Nephrology Association (IPNA) 2022 Guidelines. Method Twenty-four-hour and morning urine samples were collected from 92 pediatric NS patients. These were subjected to automated analyses for 24-h UP, UPCR, and semi-automated dipstick analysis. A blinded doctor performed manual dipstick analysis. Results UPCR had a stronger correlation with 24-h UP than with automated and manual urine dipstick tests. UPCR had the highest sensitivity and specificity for predicting no remission/relapse and high sensitivity but low specificity for complete remission. The optimal UPCR cutoff for remission was 0.44 mg/mg and for no remission/relapse was 2.08 mg/mg. Automated and manual dipstick tests demonstrated limited sensitivity but high specificity and similar AUC values for remission/relapse. Conclusion UPCR was sensitive and specific for diagnosing no remission/relapse and sensitive but not specific for detecting remission. Manual and automated urine dipstick tests were comparable for remission and no remission/relapse detection. This study supports the IPNA 2022 Guidelines, as 2 mg/mg was the optimal UPCR cutoff for no remission/relapse, while for remission the optimal cutoff was 0.4 mg/mg.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of three spot proteinuria measurements for pediatric nephrotic syndrome: based on the International pediatric Nephrology Association 2022 Guidelines

Ambarsari,

Utami,

Tandri

et al. 2023

Renal Failure

View full text Add to dashboard Cite

show abstract

A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis

Han

Dai

et al. 2022

Front. Physiol.

View full text Add to dashboard Cite

Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acute symptoms usually disappear without treatment. Endothelial cells are distributed on the inner surfaces of blood vessels and lymphatic vessels, and have important functions in metabolism and endocrine function, as well as being the primary targets of external stimuli and endogenous immune activity. Injury to endothelial cells is a feature of IgA vasculitis. Endothelial cell damage may be related to the deposition of immune complexes, the activation of complement, inflammatory factors, and chemokines, oxidative stress, hemodynamics, and coagulation factors. Both epigenetic mechanisms and genetic diversity provide a genetic background for endothelial cell injury. Here, research on the role of endothelial cells in allergic IgA vasculitis is reviewed.

show abstract

Diagnostic efficacy and influence factors of urinary protein/creatinine ratio replacing 24-h urine protein as an evaluator of proteinuria in children

Cited by 2 publications

References 33 publications

Comparison of three spot proteinuria measurements for pediatric nephrotic syndrome: based on the International pediatric Nephrology Association 2022 Guidelines

Comparison of three spot proteinuria measurements for pediatric nephrotic syndrome: based on the International pediatric Nephrology Association 2022 Guidelines

A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis

Contact Info

Product

Resources

About