Diagnostic Efficacy of 18F-FDG PET/MRI in Peripheral Nerve Injury Models

Nam, Ji Sun; Lee, Mi Jee; Kim, Hyung Jun

doi:10.1007/s11064-019-02846-w

Cited by 11 publications

(10 citation statements)

References 24 publications

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“…These observations may be due to increased spontaneous firing of neurons or part of the response to nerve injury (Behera et al, 2011). After nerve injury, the inflammatory reduces the glucose concentration in the injured nerve, thereby increasing the phosphorylation of FDG, which, in turn, increases the relative SUV (Nam et al, 2019). Our study also found that the sciatic nerve of the CCI group had a higher SUV value than the S group, and the relative SUV of the injured sciatic nerve was significantly lower than that of the CCI group after 10 Hz-rTMS treatment.…”

Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation regulates neuroinflammation, relieves hyperalgesia and reverses despair‐like behaviour in chronic constriction injury rats

Zhu

et al. 2022

Eur J of Neuroscience

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Repetitive transcranial magnetic stimulation (rTMS) could effectively relieve the pain and depression in neuropathic pain (NP) patients. However, the specific treatment parameters and exact mechanism are still unclear. Our purpose is to observe the effects of rTMS on pain and despair-like behaviour in chronic constriction injury (CCI) rats and explore its possible mechanism. Thirty-two 8-week-old male Sprague-Dawley rats were randomly divided into four groups: sham operation group (S, n = 8), CCI group (n = 8), 1 Hz-rTMS group (n = 8) and 10 Hz-rTMS group (n = 8). The rTMS was applied to the left dorsal anterior agranular insular (AId) 1 week after the operation, once a day, 5 days/week for 4 consecutive weeks. Mechanical hyperalgesia, despair-like behaviours and sciatic nerve function were used to evaluate the effects of rTMS. Besides, glucose metabolism, the metabotropic glutamate receptors 5 (mGluR5), N-Methyl-D-Aspartic acid receptor type 2B (NMDAR2B), tumour necrosis factor-α (TNF-α), interleukin-6 (Ll-6) and interleukin-1β (Ll-1β) in AId were tested to explore the possible mechanism. Compared with 1 Hz-rTMS, the rats of 10 Hz-rTMS had higher the mechanical hyperalgesia, higher sugar preference and shorter swimming immobility time. Besides, the expressions of mGluR5, NMDAR2B, TNF-α, Ll-1β and Ll-6 both in 1 Hz-rTMS and 10 Hz-rTMS groups were reduced compared with the CCI group; the 10 Hz-

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Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation regulates neuroinflammation, relieves hyperalgesia and reverses despair‐like behaviour in chronic constriction injury rats

Zhu

et al. 2022

Eur J of Neuroscience

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“…Moreover, rat models provide a nerve trunk with su cient length and space for surgical manipulation and allow the investigator to apply direct trauma [6]. Our previous paper showed the effectiveness of PET/MRI in diagnosing peripheral nerve damage with two well-known nerve models: the chronic constriction injury (CCI) and crushing injury models [4]. PET/MRI showed signi cant ndings consistent with those of histological and functional tests.…”

Section: Introductionmentioning

confidence: 80%

“…There have been few systematic in vivo nerve injury studies (as mentioned in a previous paper) [4]. Rat models are considered ideal models for nerve damage and regeneration due to ease of availability and similarities in the appearance of nerve bundles compared with humans [5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Peripheral Nerve Injury According to the Severity of Damage Using 18F-FDG PET/MRI in a Rat Model of Sciatic Nerve Injury

Park

Lee

Kim

et al. 2022

Preprint

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Reports suggest a high incidence of nerve injuries, and diverse methods, such as two-point discrimination and the pin prick test, have been attempted to evaluate the severity of nerve damage. However, these tests rely on subjective sensations and may not accurately represent the damaged area. A previous experiment revealed that 18F‑FDG positron emission tomography/magnetic resonance imaging (PET/MRI) detect peripheral nerve damage. This study aimed to assess peripheral nerve damage according to severities of damage using 18F-FDG PET/MRI in a rat sciatic nerve. Eighteen rats were divided into three groups: 30-second (G1), 2-minute (G2), and 5-minute (G3) crushing injury groups. The severity of nerve damage was measured in the third week after the crushing injury using three methods: revised withdrawal threshold (RevWT)), standardized uptake values ratio on PET/MRI (SUVR), and immunohistochemistry (intensity ratio (IntR)). There were significant differences between G1 and G3 in both SUVR and IntR. There were no significant differences in both SUVR and IntR between G2 and G3 and no significant differences in RevWT among the three groups. There was a significant difference in SUVR but no significant difference in IntR between G1 and G2. Although PET/MRI did not show results consistent with the immunohistochemistry in all respects, this study demonstrated that the severity of nerve damage as assessed by PET/MRI increased with a longer crushing time. PET/MRI showed potential as an objective diagnostic tool in this peripheral nerve injury model. If research is supplemented through further experiments, PET/MRI can be used as an effective diagnostic modality.

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“…To date, several studies have reported the potential of 18 F-FDG as a tool for imaging peripheral and chronic pain. 34,35 However, for cancer patients, such a strategy is particularly challenging, given that 18 F-FDG often serves as the gold standard for whole-body imaging of many cancers, limiting its effectiveness in visualizing peripheral nerves.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Of the imaging modalities available for noninvasive imaging, positron emission tomography (PET) has established itself as one of the most powerful tools in this field. To date, several studies have reported the potential of 18 F-FDG as a tool for imaging peripheral and chronic pain. , However, for cancer patients, such a strategy is particularly challenging, given that 18 F-FDG often serves as the gold standard for whole-body imaging of many cancers, limiting its effectiveness in visualizing peripheral nerves.…”

Section: Discussionmentioning

confidence: 99%

Bimodal Imaging of Mouse Peripheral Nerves with Chlorin Tracers

et al. 2021

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Almost 17 million Americans have a history of cancer, a number expected to reach over 22 million by 2030. Cancer patients often undergo chemotherapy in the form of antineoplastic agents such as cis-platin and paclitaxel. Though effective, these agents can induce debilitating side effects; the most common neurotoxic effect, chemotherapy-induced peripheral neuropathy (CIPN), can endure long after treatment ends. Despite the widespread and chronic nature of the dysfunction, no tools exist to quantitatively measure chemotherapy-induced peripheral neuropathy. Such a tool would not only benefit patients but their stratification could also save significant financial and social costs associated with neuropathic pain. In our first step toward addressing this unmet clinical need, we explored a novel dual approach to localize peripheral nerves: Cerenkov luminescence imaging (CLI) and fluorescence imaging (FI). Our approach revolves around the targeting and imaging of voltage-gated sodium channel subtype Na V 1.7, highly expressed in peripheral nerves from both harvested human and mouse tissues. For the first time, we show that Hsp1a, a radiolabeled Na V 1.7-selective peptide isolated from Homoeomma spec. Peru, can serve as a targeted vector for delivering a radioactive sensor to the peripheral nervous system. In situ, we observe high signal-to-noise ratios in the sciatic nerves of animals injected with fluorescently labeled Hsp1a and radiolabeled Hsp1a. Moreover, confocal microscopy on fresh nerve tissue shows the same high ratios of fluorescence, corroborating our in vivo results. This study indicates that fluorescently labeled and radiolabeled Hsp1a tracers could be used to identify and demarcate nerves in a clinical setting.

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Diagnostic Efficacy of 18F-FDG PET/MRI in Peripheral Nerve Injury Models

Cited by 11 publications

References 24 publications

Repetitive transcranial magnetic stimulation regulates neuroinflammation, relieves hyperalgesia and reverses despair‐like behaviour in chronic constriction injury rats

Repetitive transcranial magnetic stimulation regulates neuroinflammation, relieves hyperalgesia and reverses despair‐like behaviour in chronic constriction injury rats

Evaluation of Peripheral Nerve Injury According to the Severity of Damage Using 18F-FDG PET/MRI in a Rat Model of Sciatic Nerve Injury

Bimodal Imaging of Mouse Peripheral Nerves with Chlorin Tracers

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