Diagnostic efficacy of the magnetic resonance T1w/T2w ratio for the middle cerebellar peduncle in multiple system atrophy and spinocerebellar ataxia: A preliminary study

Abstract

Background The standardized T1-weighted/T2-weighted (sT1w/T2w) ratio for the middle cerebellar peduncle (MCP) has been reported to be sensitive for detecting degenerative changes in the cerebellar subtype of multiple system atrophy (MSA-C), even in the early stages. We aimed to investigate the diagnostic value of the MCP sT1w/T2w ratio for differentiating between MSA-C and spinocerebellar ataxia (SCA). Methods We included 32 MSA-C, 8 SCA type 3 (SCA3), 16 SCA type 6 (SCA6) patients, and 17 controls, and the MCP sT1w/T2w ratio was analyzed using a region-of-interest approach. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating among MSA-C, SCA3, and SCA6 was assessed and compared with diagnosis based on visual interpretation of MCP hyperintensities and the “hot cross bun” (HCB) sign. Results MCP sT1w/T2w ratio values were markedly lower in patients with MSA-C than in those with SCA3, those with SCA6, and controls (p < 0.001). The MCP sT1w/T2w ratio showed high diagnostic accuracy for distinguishing MSA-C from SCA3 (area under curve = 0.934), SCA6 (area under curve = 0.965), and controls (area under curve = 0.980). The diagnostic accuracy of the MCP sT1w/T2w ratio for differentiating MSA-C from SCA3 or SCA6 (90.0% for MSA-C vs. SCA3, and 91.7% for MSA-C vs. SCA6) was comparable to or superior than that of visual interpretation of MCP hyperintensities (80.0–87.5% in MSA-C vs. SCA3 and 87.6–97.9% in MSA-C vs. SCA6) or the HCB sign (72.5–80.0% in MSA-C vs. SCA3 and 77.1–93.8% in MSA-C vs. SCA6). Conclusions The MCP sT1w/T2w ratio might be a sensitive imaging-based marker for detecting MSA-C-related changes and differentiating MSA-C from SCA3 or SCA6.

Differentiation between Parkinson’s Disease and the Parkinsonian Subtype of Multiple System Atrophy Using the Magnetic Resonance T1w/T2w Ratio in the Middle Cerebellar Peduncle

“…Consistent with the current study results, our previous studies revealed that the MCP sT1w/T2w ratio can differentiate patients with early MSA-C from those with hereditary spinocerebellar ataxia [26,27]. Pathologically, reactive gliosis and the loss of axons and myelin are the MSA-related degenerative changes in the MCP [37], presumably reflected in the decreased MSA sT1w/T2w ratio [27].…”

“…Standardization of the T1w/T2w ratio (sT1w/T2w ratio) has been proposed, allowing for a meaningful comparison between subjects and scanners by creating scaled intensity while correcting for inhomogeneities in receiver coil sensitivity [25]. We previously reported that using the sT1w/T2w ratio for evaluating MCP can help detect early MSA-C-related degenerative changes (e.g., myelin loss), considering that it shows high diagnostic accuracy in differentiating patients with MSA-C from healthy individuals and those with spinocerebellar ataxia [26,27]. However, the usefulness of MCP sT1w/T2w ratio in differentiating between MSA-P and PD remains unreported.…”