Diagnostic Efficiency of Quantitative Contrast‐Enhanced Ultrasound Indicators for Discriminating Benign From Malignant Solid Thyroid Nodules

Zhang, Xiaohui; Zhou, Ping; Hu, Zheyu; Tian, Shuang Ming; Zhao, Yongfeng; Liu, Wengang; Jin, Qiuzi

doi:10.1002/jum.14347

Cited by 33 publications

(34 citation statements)

References 19 publications

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“…The main reason that thyroid malignant tumors show a lack of blood supply is that the tumors grows with complex neovascularization inside it; once the growth outweighs neovascularization, necrosis and embolus formation happens within the tumor, ultimately leading to hypoenhancement on CEUS. Moreover, Zhou et al [ 20 ] found that instead of hypoenhancement, the nodule-to-perinodule peak intensity ratio showed the best diagnostic efficiency, with an optimal cutoff value of 0.9.…”

Section: Ceus Patterns Characteristic Of Malignant Thyroid Nodulesmentioning

confidence: 99%

“…A previous study [ 41 ] reported that the combination of US, RTE, and CEUS could increase both the sensitivity and specificity of all three methods. With regard to comparisons between individual methods, most studies [ 20 , 42 , 43 ] showed that RTE was the most valuable tool. Giusti et al [ 44 ] found that RTE and CEUS showed no advantages over US, and in a further study, demonstrated that the information added by CEUS was less sensitive than that provided by US and RTE.…”

Section: Ceus Combined With Real-time Elastography and Conventional Umentioning

confidence: 99%

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Application of contrast-enhanced ultrasound for evaluation of thyroid nodules

Zhan

Ding

2018

Ultrasonography

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Contrast-enhanced ultrasound (CEUS) is widely used to evaluate tumor microcirculation, which is useful in the differential diagnosis between benignity and malignancy. In the last 10 years, the applicability of CEUS to thyroid nodules has greatly improved due to technological refinements and the development of second-generation contrast agents. In this review, we summarize the applications of CEUS for thyroid nodules, focusing on the imaging findings of malignant and benign nodules in the existing literature and the use of those findings to predict malignancies, with an additional brief description of the utilization of CEUS for other thyroid-related diseases.

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Section: Ceus Patterns Characteristic Of Malignant Thyroid Nodulesmentioning

confidence: 99%

Section: Ceus Combined With Real-time Elastography and Conventional Umentioning

confidence: 99%

Application of contrast-enhanced ultrasound for evaluation of thyroid nodules

Zhan

Ding

2018

Ultrasonography

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“…Is an FNA biopsy indicated in cases involving combined calcification in the same nodule, even if a high risk of a false negative has been described? In a retrospective study, Zhou et al [12] studied the quantitative contrast-enhanced US indicators for discriminating between benign and malignant thyroid nodules. The authors concluded that quantitative contrast-enhanced US may be useful and that the nodule to peri-nodule peak intensity ratio showed the best diagnostic efficacy; however, the situation remains unclear and controverted.…”

Section: Discussionmentioning

confidence: 99%

A case of mixed-pattern calcifications in multinodular goiter associated with a benign diagnosis

Bianchi

Morandi

Stefani

et al. 2019

International Journal of Surgery Case Reports

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Highlights Calcified nodules in a goiter are often found when performing an ultrasound of the neck. Analysis of different calcification patterns could contribute to discriminating between nodules. Mixed pattern calcifications is not so frequent and not interpreted. We believe that a better radiologic evaluation setting of thyroid nodules needs to be performed.

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“…In previous studies, researchers have demonstrated that, under CEUS, ring enhancement showed an accuracy of 88.5% for benign lesions, and heterogeneous enhancement showed an accuracy of 90.4% for malignant lesions (22). Li et al (23) concluded that low, weak, or uneven enhancements are valuable perfusion features for evaluating papillary thyroid carcinoma but that a uniform, high-enhanced perfusion mode was typical of benign nodules.…”

Section: Discussionmentioning

confidence: 99%

Advantages of the Korean Thyroid Imaging Reporting and Data System Combined with Contrast-Enhanced Ultrasound in Diagnosing Papillary Thyroid Microcarcinoma

Huaqun

Liu

et al. 2019

Iran J Radiol

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Background:A papillary thyroid microcarcinoma (PTMC) may have the characteristics of different types of lesions, usually leading to preoperative ultrasound diagnosis. Therefore, new diagnostic methods need to be developed. Objectives: This study aimed to evaluate the advantages of the Korean thyroid imaging reporting and data system (TI-RADS) combined with contrast-enhanced ultrasound (CEUS) in diagnosing PTMC. Patients and Methods: In total, 143 patients who had a total of 150 micro space-occupying lesions of the thyroid and underwent conventional ultrasonography (US) and CEUS were enrolled. The diagnostic value of the benign nodule and PTMC by TI-RADS, CEUS and combined method were compared. The independent US and CEUS predictors for PTCM were determined and quantified using logistic regression analysis. Results: The TI-RADS + CEUS combination had the highest accuracy (95.10%), sensitivity (96.74%), specificity (94.83%), positive prediction value (87.92%) and negative prediction value (98.02%), significantly greater than that of TI-RADS alone (area under the curve [AUC]: 0.930 vs. 0.873, P < 0.001; accuracy: 95.10% vs. 89.78%, P = 0.032; sensitivity: 96.74% vs. 86.05%, P = 0.041; positive predictive value [PPV]: 87.92% vs. 76.47%, P = 0.029) and CEUS alone (AUC: 0.930 vs. 0.857, P < 0.001; accuracy: 95.10% vs. 86.93%, P < 0.001; negative predictive value [NPV]: 98.02% vs. 90.83%, P = 0.047). Multivariate stepwise logistic regression showed that calcification (odds ratio [OR] = 1.586; 95% confidence interval [CI]: 1.037 -2.311; P = 0.027), hypoechogenicity (OR = 1.432; 95%CI: 0.975 -1.925; P = 0.035), and hypo-enhancement (OR = 2.140; 95%CI: 1.237 -2.840; P = 0.019) were the optimal predictor for PTMC. Conclusion: TI-RADS in combination with CEUS has superior diagnostic efficiency in the discrimination of micro-thyroid spaceoccupying lesions, which can improve the diagnostic accuracy of PTMC.

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Diagnostic Efficiency of Quantitative Contrast‐Enhanced Ultrasound Indicators for Discriminating Benign From Malignant Solid Thyroid Nodules

Abstract: Quantitative contrast-enhanced US indicators help discriminate benign from malignant thyroid nodules. The nodule-to-perinodule peak intensity ratio showed the best diagnostic efficiency.

Cited by 33 publications

References 19 publications

Application of contrast-enhanced ultrasound for evaluation of thyroid nodules

Application of contrast-enhanced ultrasound for evaluation of thyroid nodules

A case of mixed-pattern calcifications in multinodular goiter associated with a benign diagnosis

Advantages of the Korean Thyroid Imaging Reporting and Data System Combined with Contrast-Enhanced Ultrasound in Diagnosing Papillary Thyroid Microcarcinoma

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