Diagnostic Enigma of Adenoid Ameloblastoma: Literature Review Based Evidence to Consider It as a New Sub Type of Ameloblastoma

Jayasooriya, Primali Rukmal; Abeyasinghe, W A M Udari L; Liyanage, Rubasinha Liyanage Pemith Ranura; Uthpali, Gunandahandi N; Tilakaratne, Wanninayake Mudiyanselage

doi:10.1007/s12105-021-01358-w

Cited by 25 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Metastasizing ameloblastoma was reclassified as a benign tumor rather than a malignant odontogenic tumor, as this tumor shows benign histopathology, in spite of its metastatic potential, thus rendering it difficult to differentiate histopathologically from conventional ameloblastoma [5]. Recently, there has been an effort for the inclusion of adenoid ameloblastoma as a sub-type of ameloblastoma in the next revision of the WHO odontogenic tumor classification [8]. Adenoid ameloblastoma is a hybrid odontogenic tumor showing histopathological features of both ameloblastoma and adenomatoid odontogenic tumor.…”

Section: Classificationmentioning

confidence: 99%

“…Adenoid ameloblastoma is a hybrid odontogenic tumor showing histopathological features of both ameloblastoma and adenomatoid odontogenic tumor. Adenoid ameloblastoma is demographically similar to conventional ameloblastoma but with histopathological differences and presents with a higher rate/multiple recurrences, indicating its biological aggressiveness [8].…”

Section: Classificationmentioning

confidence: 99%

“…Recently, there has been an effort for the inclusion of adenoid ameloblastoma as a sub-type of ameloblastoma in the next revision of the WHO odontogenic tumor classification [ 8 ]. Adenoid ameloblastoma is a hybrid odontogenic tumor showing histopathological features of both ameloblastoma and adenomatoid odontogenic tumor.…”

Section: Reviewunclassified

See 2 more Smart Citations

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ghai¹

2022

Cureus

View full text Add to dashboard Cite

Ameloblastoma is one of the most common benign odontogenic tumors of the jaw that constitutes about 10% of all tumors that arise in the mandible and maxilla. It is a slow-growing but locally invasive tumor that presents with painless swelling of the mandible or maxilla. The World Health Organization (WHO) classification of 2017 describes ameloblastomas of the following four types: ameloblastoma; unicystic ameloblastoma; extraosseous/peripheral ameloblastoma; and metastasizing ameloblastoma. The diagnosis of ameloblastoma requires computerized tomography (CT) imaging as well as a biopsy. A biopsy is helpful in differentiating ameloblastoma from ossifying fibroma, osteomyelitis, giant cell tumor, cystic fibrous dysplasia, myeloma, and sarcoma. The best treatment of ameloblastoma is aggressive en bloc resection with simultaneous reconstruction. The high recurrence rate and large tissue defects have been long-standing issues in the treatment of ameloblastoma. Recent molecular developments strongly suggest the possibility of targeted therapy with better outcomes in ameloblastomas. We present a detailed updated narrative review of our current understanding and management of this enigmatic tumor.

show abstract

Section: Classificationmentioning

confidence: 99%

Section: Classificationmentioning

confidence: 99%

See 1 more Smart Citation

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ghai¹

2022

Cureus

View full text Add to dashboard Cite

show abstract

“…Moreover, adenoid ameloblastoma is considered as more biologically aggressive type with higher recurrence rate than conventional ameloblastoma. In contrast to other ameloblastoma types, BRAF V600E mutations are not present in the adenoid type [23].…”

Section: Classificationmentioning

confidence: 62%

“…It is also characterized by possible presence of dentinoid, ghost and clear cells [22]. The hybrid histological pattern including both ameloblastoma and adenomatoid odontogenic tumor characteristics was reported in approximately 40 cases in the literature [23]. Moreover, adenoid ameloblastoma is considered as more biologically aggressive type with higher recurrence rate than conventional ameloblastoma.…”

Section: Classificationmentioning

confidence: 99%

Perspective Chapter: Ameloblastoma – Present and Future Concepts of Managing

Gabrić¹,

Bjelica²,

Sušić³

et al. 2023

Bone Tumours - A Comprehensive Review of Selected Topics

View full text Add to dashboard Cite

Ameloblastoma is a benign odontogenic tumor of epithelial origin with locally aggressive behavior. It affects a broad age range of patients and it is most commonly found in the mandible, especially posterior area. The majority of ameloblastomas are conventional (multicystic), which are more difficult to eradicate than the unicystic or peripheral types. Although most of ameloblastoma cases can be treated predictably with radical surgical treatment, the management of recurrent and metastasizing ameloblastomas remains a major challenge. Surgical treatment is standard, but the extent of resection is controversial. Radical resection with segmental and marginal mandibulectomy or curettage and enucleation with better quality of life, but with higher recurrence rate. Besides the conventional surgical treatment, novel therapy options like neoadjuvant molecular targeted therapy and decompression in young patients could make a significant improvement in the management of the disease. The aim of this chapter was to determine the present and future concepts of treatment and discuss significant factors responsible for recurrence.

show abstract

Die neue WHO-Klassifikation der Kiefertumoren

Haefliger

Baumhoer

2023

Pathologie

View full text Add to dashboard Cite

ZusammenfassungOdontogene Tumoren und Kiefertumoren umfassen ein breites Spektrum an Läsionen, darunter Neoplasien, hamartomatöse Veränderungen und Entwicklungsstörungen. Seit Anfang 2022 ist eine Beta-Version der 5. Auflage der WHO-Klassifikation für Kopf-Hals-Tumoren online verfügbar, die voraussichtlich Mitte 2023 auch als Printversion erscheinen wird. Konzeptionell hat sich im Vergleich zur 4. Auflage nicht viel verändert. Die Reihenfolge der Läsionen ist stringenter nach Dignität geordnet und die gleichen Tumoren werden nicht mehr in verschiedenen Kapiteln lokalisationsabhängig mehrfach beschrieben. Diagnostische Kriterien werden neu in „essential“ und „desirable“ zusammengefasst. Zusätzlich zu den klinischen Aspekten wird nun auch die Bildgebung miteinbezogen und die Klassifikation damit interdisziplinär. Vereinzelt sind auch neue Läsionen erstmals aufgeführt. Dieser Artikel gibt einen Überblick über die Neuerungen der neuen Klassifikation mit einem speziellen Fokus auf die Einteilung der fibroossären Kieferläsionen.

show abstract

Diagnostic Enigma of Adenoid Ameloblastoma: Literature Review Based Evidence to Consider It as a New Sub Type of Ameloblastoma

Cited by 25 publications

References 25 publications

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Perspective Chapter: Ameloblastoma – Present and Future Concepts of Managing

Die neue WHO-Klassifikation der Kiefertumoren

Contact Info

Product

Resources

About