Diagnostic evaluation of sentinel lymph node biopsy in early head and neck squamous cell carcinoma: A meta‐analysis

Yamauchi, Kohichi; Kogashiwa, Yasunao; Nakamura, Takehiro; Moro, Yorihisa; Nagafuji, Hiroshi; Kohno, Naoyuki

doi:10.1002/hed.23526

Cited by 32 publications

(23 citation statements)

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“…8,9 Although SLNB might reduce part of these issues, 10 it is a time-consuming and technically challenging procedure, which still does not prevent an open surgical approach. 1,2 Elective neck dissection is currently regarded as the treatment of choice for HNSCC patients with a cN0 status.…”

Section: Discussionmentioning

confidence: 99%

“…Sentinel lymph node biopsy (SLNB) is less invasive than up-front neck dissection and holds promises in HNSCC. 10 However, SLNB is still an invasive procedure. In addition, this technique is time-consuming, technically challenging, and requires a close collaboration between different medical specialties, making its use only possible in dedicated centers.…”

Section: Introductionmentioning

confidence: 99%

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Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification

et al. 2016

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“…Furthermore, most previous individual studies contained too small of a sample size to yield a valid conclusion. In addition, previous meta-analyses mainly focused on head and neck cancer or oral and oropharyngeal carcinoma [13–16]. However, combining different subset of head and neck cancer with differing clinical characteristics and metastasis patterns, can lead to heterogeneous results for SLNB.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Efficacy of Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Meta-Analysis of 66 Studies

et al. 2017

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ObjectivesThe diagnostic efficacy of sentinel lymph node biopsy(SLNB) in early oral squamous cell carcinoma(OSCC) still remains controversial. This meta-analysis was conducted to assess the diagnostic value of SLNB in clinically neck-negative T1-2 OSCC.MethodsA systematic literature search for relevant literature published up to September 11, 2016 was conducted in PubMed, Embase, Web of Science, Cochrane Library and ClinicalTrials, and the reference lists of eligible studies were examined. Data from different studies were pooled to estimate the summary sentinel lymph node(SLN) identification rate, sensitivity, negative predictive value. Summary receiver operator characteristic curve(SROC) was plotted and area under the SROC curve (AUC) was calculated to evaluate the overall diagnostic efficacy. Threshold effect was assessed with use of the spearman correlation coefficient. Between-study heterogeneity was tested using the Q tests and the I2 statistics. Subgroup analyses were conducted in view of the greater effect of different study characteristics on diagnostic efficacy of SLN. Deeks’ funnel plot asymmetry test was performed to evaluate publication bias. Sensitivity analysis was evaluated through omitting studies one by one and comparing the pooled results of random-effects model and fixed-effects model. All analyses were performed using Review Manager (version 5.3.5), Meta-DiSc (version 1.4), Comprehensive Meta Analysis (version 2.0) and STATA (version 12).Results66 studies comprising 3566 patients with cT1-2N0 OSCC were included in this meta-analysis. The pooled SLN identification rate was 96.3%(95% CI: 95.3%-97.0%). The pooled sensitivity was 0.87 (95% CI: 0.85–0.89), pooled negative predictive value was 0.94 (95% CI: 0.93–0.95), and AUC was 0.98 (95% CI: 0.97–0.99). Subgroup analyses indicated that SLN assessment with immunohistochemistry(IHC) achieved a significantly higher sensitivity than without IHC.ConclusionsThis meta-analysis suggests that SLNB has a high diagnostic accuracy in cT1-2N0 oral squamous cell carcinoma, and is an ideal alternative to elective neck dissection. Furthermore, the use of IHC can significantly improve SLNB diagnostic sensitivity for early OSCC.

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“…The pooled false-negative value calculated by a meta-analysis of SLN biopsy studies for head and neck SCC was 13.7%. 76 On the basis of the limited experience with SLN biopsies of SCC of the periocular region, the positivity rate is 12.5% (1/8) 22 to 14% (1/7) 25 with no reports of false-negative biopsies as of yet. One article describes positive SLN biopsy findings in all 5 patients with periocular invasive SCC in their series.…”

Section: Squamous Cell Carcinoma (Scc) Of the Eyelid And Conjunctivamentioning

confidence: 99%

Sentinel Lymph Node Biopsy for Eyelid and Conjunctival Tumors

Mendoza¹,

Grossniklaus²

2015

International Ophthalmology Clinics

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Diagnostic evaluation of sentinel lymph node biopsy in early head and neck squamous cell carcinoma: A meta‐analysis

Abstract: The SLNB procedure has shown a high sensitivity rate, but the pooled sensitivity and false-negative rate were worse in SLNB alone trials than in SLNB validation trials.

Cited by 32 publications

References 50 publications

Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification

Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification

Diagnostic Efficacy of Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Meta-Analysis of 66 Studies

Sentinel Lymph Node Biopsy for Eyelid and Conjunctival Tumors

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