Diagnostic fibreoptic bronchoscopy in the immunocompromised host with pulmonary infiltrates.

Matthay, Richard A.; Farmer, William; Odero, Dixon

doi:10.1136/thx.32.5.539

Cited by 58 publications

(11 citation statements)

References 18 publications

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“…A considerably lower yield is obtained if bronchial brushing alone is employed, varying from 28%8 to 63%. 16 In the initial phase of the study we repeated the procedure for a second or even third time in those patients where TBB revealed nonspecific changes. We found these repeat procedures unhelpful in that they did not provide further information, and the patients' later progress did not suggest that any treatable condition had been missed.…”

Section: Discussionmentioning

confidence: 99%

“…The bronchoscope was passed transnasally into the trachea after lignocaine administration into the nose and oropharynx. 16 Once the trachea had been entered, a trap was inserted into the suction line to collect any secretions or washings, and the bronchoscope was advanced further into the tracheobronchial tree with administration of 2% lignocaine to prevent and control coughing. In the two patients who were venti'lated, the bronchoscope was passed directly into the trachea via an endotracheal tube through a connector that provides an airtight seal.…”

Section: Methodsmentioning

confidence: 99%

“…Many studies have shown FOB to be a useful and relatively safe technique in the diagnosis of pulmonary lesions,'13-1 but very few patients with lymphoma or leukaemia have been studied using full bronchoscopic technique. 16 We describe an evaluation of FOB in a group of patients with Hodgkin's disease, lymphoma, or leukaemia, many of whom had risk factors present. All these patients had FOB, with regional alveolar lavage, endobronchial brushing, and transbronchial lung biopsies where appropriate.…”

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confidence: 99%

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Fibreoptic bronchoscopy and diagnosis of pulmonary lesions in lymphoma and leukaemia.

Phillips¹,

Knight²,

Green³

1980

Thorax

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Fifty-six fibreoptic bronchoscopies were performed on 42 patients with Hodgkin's disease, lymphoma, or leukaemia and pulmonary complications which did not respond to conventional antibiotics. All these patients had received chemotherapy, radiotherapy, or both for the treatment of their underlying conditions. Twenty-two bronchoscopic procedures were complicated by thrombocytopenia and neutropenia, requiring platelet transfusion before bronchoscopy, and many patients were hypoxaemic. Visual examination of the tracheobronchial tree, alveolar lavage, bronchial brushing, and transbronchial biopsy were carried out as approximate. Three patients had minor pulmonary haemorrhage, and three developed a pneumothorax after transbronchial biopsy. A specific diagnosis was obtained in 14 of 18 patients (78%) with diffuse chest radiographic abnormalities, in seven of 11 patients (64%) with lobar or segmental (focal) abnormalities, in two of eight patients with small (local) lesions, and in three of five patients with hilar abnormalities. In only three patients were infections diagnosed. It is concluded that fibreoptic bronchoscopy is a useful and safe diagnostic procedure in this situation but its value depends upon the type of radiological abnormality.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Fibreoptic bronchoscopy and diagnosis of pulmonary lesions in lymphoma and leukaemia.

Phillips¹,

Knight²,

Green³

1980

Thorax

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“…Of these, 19 patients (12 male, mean age 50 years, range initially or subsequently presented with pulmonary infiltrates which required specialized respiratory investigation. Three patients had two separate periods of investigation; on each occasion the chest X-ray was distinctly different and the admissions were more than 2 months apart.…”

Section: Methodsmentioning

confidence: 99%

Pulmonary infiltrates--diagnostic problems in lymphoma

Raina²,

Banham³

et al. 1989

Postgraduate Medical Journal

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Summary:The use of invasive investigations in immunocompromised patients with pulmonary infiltrates is controversial. We report a series of 22 pulmonary lesions occurring in 19 patients with underlying Hodgkin's (7) and non-Hodgkin's (12) lymphoma in whom invasive investigations were performed. The principle techniques used were fibreoptic bronchoscopy, bronchoalveolar lavage and transbronchial lung biopsy. A specific diagnosis was made on 12 occasions (55%). Involvement of the lung with lymphoma (6) and cytotoxic drug induced pneumonitis (4) were the commonest diagnoses, infection being found on only one occasion. In 15 of these 22 procedures (68%) the information obtained made a positive contribution to patient management.

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“…[12][13][14] Henceforth, numerous studies examined the role of fiberoptic bronchoscopy and the diagnostic yield of TBBx in various clinical settings. 11,[15][16][17][18][19][20][21][22][23] The open lung biopsy (OLBx) only became technologically feasible after World War II along with major advances in surgical technique, anesthesia, and antibiotic therapy. In 1949, Klassen described the small anterior thoracotomy for the procurement of lung tissues.…”

Section: Historical Developmentsmentioning

confidence: 99%

Use and Abuse of Lung Biopsy

Gal¹

2005

Advances in Anatomic Pathology

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The lung biopsy is widely recognized as a valuable tool for the diagnosis and management of diverse pulmonary disorders. The transbronchial lung biopsy, open lung biopsy, and video assisted thoracoscopic surgery biopsy are the principal tools that have been developed for obtaining lung tissue for histopathological examination. Whereas these various types of lung biopsies are highly sensitive and specific tests available for diagnosis, they may be fraught with potential problems. This review hopes to inform the reader of the indications and limitations of the lung biopsy.

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Diagnostic fibreoptic bronchoscopy in the immunocompromised host with pulmonary infiltrates.

Cited by 58 publications

References 18 publications

Fibreoptic bronchoscopy and diagnosis of pulmonary lesions in lymphoma and leukaemia.

Fibreoptic bronchoscopy and diagnosis of pulmonary lesions in lymphoma and leukaemia.

Pulmonary infiltrates--diagnostic problems in lymphoma

Use and Abuse of Lung Biopsy

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