Diagnostic Heterogeneity in Relation to Drug Evaluation: Antidepressants

Paykel, Eugene S.

doi:10.1007/978-3-642-78010-3_15

Cited by 1 publication

(2 citation statements)

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“…data]. This clinical impression may be caused by the delayed onset of the effect of antidepressives [16] or by small relapses registered after conclusion of TMS. We believe the antidepressive effect of TMS to be intrinsic rather than a possible trigger for the drug action, a view also held by other authors [11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

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Transcranial Magnetic Stimulation: A Novel Antidepressive Strategy?

Conca¹,

Koppi²,

König³

et al. 1996

Neuropsychobiology

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Transcranial magnetic stimulation (TMS) is a well-established diagnostic probe in neurological practice. The increasing knowledge of biological mechanisms in electroconvulsive therapy presents a clear case for studying the applicability of TMS as a therapeutic tool in psychiatry. Based on the results of our pilot study showing a possible antidepressive effect of TMS, we conducted a controlled clinical trial on patients affected by major depression (DSM-III-R). Group 1 (n = 12) underwent TMS as add-on therapy to standard antidepressive medication, while group 2 (n = 12) was treated only with antidepressive medication. Already after the third add-on TMS session, a statistically significantly greater remission of depressive symptoms occurred in the patients of group 1 (p = 0.003). This statistically significant difference between the groups became even more marked on the last day of the study (p = 0.001, Wilcoxon). The results and further implications of TMS in psychiatric disorders are discussed.

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Section: Discussionmentioning

confidence: 99%

“…All were put on monitored adequate antidepressive medication comprising selective serotonin uptake inhibitors (paroxetine or citalopram) and/or polycyclic antidepressants (amitriptyline, maprotilinc. trazodone: table 2, 3) [16,17], Patients on medication at entry underwent a 3-day washout.…”

Section: Methodsmentioning

confidence: 99%