Diagnostic imaging of breast cancer with LOIS: clinical feasibility

Khamapirad, Tuenchit; Henrichs, P. M.; Mehta, Ketan; Miller, Tom; Yee, Andrew; Oraevsky, Alexander A.

doi:10.1117/12.596916

Cited by 20 publications

(13 citation statements)

References 8 publications

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“…Since ultrasound scatters 2-3 orders of magnitude lower than light in soft tissue, photoacoustic imaging can offer high resolution [9]. The application of NIR photoacoustics for breast imaging has been reported by Oraevsky and co-workers [10,11] in the laser optoacoustic imaging system (LOIS) but the technique is as yet in its infancy. In a radiofrequency (RF) counterpart of NIR photoacoustics, Kruger and coworkers [12] used radiation of 434 MHz frequency for excitation in the thermoacoustic computed tomography (TCT) scanner to probe RF absorption by ionic water associated with human breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics

Manohar¹,

Vaartjes²,

Hespen³

et al. 2007

Opt. Express

261

198

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Near-infrared photoacoustic images of regions-of-interest in 4 of the 5 cases of patients with symptomatic breasts reveal higher intensity regions which we attribute to vascular distribution associated with cancer. Of the 2 cases presented here, one is especially significant where benign indicators dominate in conventional radiological images, while photoacoustic images reveal vascular features suggestive of malignancy, which is corroborated by histopathology. The results show that photoacoustic imaging may have potential in visualizing certain breast cancers based on intrinsic optical absorption contrast. A future role for the approach could be in supplementing conventional breast imaging to assist detection and/or diagnosis.

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Section: Introductionmentioning

confidence: 99%

Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics

Manohar¹,

Vaartjes²,

Hespen³

et al. 2007

Opt. Express

261

198

View full text Add to dashboard Cite

show abstract

“…He observed an audible sound generated by chopped sunlight, incident on absorbing materials. Although this effect has been known for over a century, it was only with the availability of high-energy lasers and sensitive ultrasound detectors during the last few decades that has caused a renewed interest in applications of the photoacoustic effect [2][3][4][5][6][7]. Recently, there has been an effort to improve the sensitivity and measurement time by incorporating scanning microscopy [8] and tomography with curved-array transducers [9].…”

Section: Biophotonicsmentioning

confidence: 99%

Imaging of tumor vasculature using Twente photoacoustic systems

Jose

Manohar

Kolkman

et al. 2009

Journal of Biophotonics

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Photoacoustic imaging is a hybrid imaging modality based on the detection of acoustic waves generated by the absorption of short laser pulses in biological tissue. It combines the advantages of excellent contrast achieved in optical techniques with the high resolution of ultrasound imaging. In this article we present a review of the work done at the University of Twente to image tumor angiogenesis in vivo using this technique. We start with a description and the technical details of the different photoacoustic systems developed in our laboratory, with their validation on phantoms. We then discuss small-animal studies with results of serial imaging of angiogenesis over a 10-day period at the site of tumor induction in a rat. Further, we present clinical results using a photoacoustic mammoscope of breast cancer imaging based on angiogenesis-driven optical absorption contrast.

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“…Although photoacoustic signal propagation in biological tissues is intrinsically high-speed, to achieve frame rates high enough for real-time imaging is still technologically challenging. Most pioneering studies on PAT are based on home-fabricated ultrasound signal acquisition systems that employ a single transducer or an array with only limited receiving channels [1][2][3][4][5]. Therefore, the mechanical or electrical scan of PAT signals for tomographic imaging is very time consuming, especially when the laser repetition rate is also limited.…”

Section: Introductionmentioning

confidence: 99%

A high-speed photoacoustic tomography system based on a commercial ultrasound and a custom transducer array

Wang

Cannata

DeBusschere³

et al. 2010

Photons Plus Ultrasound: Imaging and Sensing 2010

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Building photoacoustic imaging systems by using stand-alone ultrasound (US) units makes it convenient to take advantage of the state-of-the-art ultrasonic technologies. However, the sometimes limited receiving sensitivity and the comparatively narrow bandwidth of commercial US probes with elements driving long cables may not be sufficient for high quality photoacoustic imaging. In this work, a high-speed photoacoustic tomography (PAT) system has been developed using a commercial US unit and a custom built 128-element PVDF transducer array. Since the US unit supports simultaneous signal acquisition from 64 parallel receive channels, PAT data for synthetic image formation from a 64 or 128 element array aperture can be acquired after a single or dual laser firing, respectively. The PVDF array provides satisfactory receiving sensitivity and uniquely broad detection bandwidth, which enables good image quality for tomographic photoacoustic imaging. A specially designed 128-channel preamplifier board that connects the preamps directly to the PVDF elements not only enables impedance matching but also further elevates the signal-to-noise ratio in detecting weak photoacoustic signals. To examine the performance of this imaging system, experiments on phantoms were conducted and the results were compared with those acquired with commercial US probes.

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Diagnostic imaging of breast cancer with LOIS: clinical feasibility

Cited by 20 publications

References 8 publications

Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics

Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics

Imaging of tumor vasculature using Twente photoacoustic systems

A high-speed photoacoustic tomography system based on a commercial ultrasound and a custom transducer array

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