Diagnostic imaging of the nasolacrimal drainage system. Part I. Radiological anatomy of lacrimal pathways. Physiology of tear secretion and tear outflow

Maliborski, Artur; Różycki, Radosław

doi:10.12659/msm.890098

Cited by 48 publications

(14 citation statements)

References 26 publications

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“…According to previous studies, lacrimal scintigraphy, can identify treatment strategies for functionally acquired epiphora[ 13 , 14 ]. For example, a horizontal shortening of the lower eyelid may be present which can then augment the action of the lacrimal “pump” (as lower eyelid laxity has been associated with decreased lacrimal pump function[ 13 ]).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of orbicularis oculi muscle electromyography in functional epiphora

Liu

Xue

et al. 2020

WJCC

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BACKGROUND Functional epiphora is a clinical condition which is not due to an anatomic defect. Most studies agree that it involves the action of the orbicularis oculi muscle, particularly its deeper segment (Horner’s muscle), but the exact mechanism is not clear. AIM To evaluate the orbicularis oculi muscle in functional epiphora patients using electromyography (EMG). METHODS A total of 8 Chinese patients (16 eyes) with functional epiphora were enrolled in this study, and ten volunteers (10 eyes) were included as normal controls. Five epiphora patients (five eyes) with facial palsy served as positive controls. Quantitative EMG was performed in the deeper segment of orbicularis oculi muscle. The average duration of each EMG waveform was measured. RESULTS The average duration of EMG waveforms in the normal control group, the functional epiphora group, and the facial palsy group were 6.39 ± 0.73 ms, 9.39 ± 1.32 ms and 11.2 ± 1.42 ms, respectively. The duration of EMG waveforms was significantly longer in the functional epiphora group than in the normal control group ( P < 0.05), and shorter than that in the facial palsy group ( P < 0.05). CONCLUSION These data indicate the presence of neurogenic orbicularis oculi muscle damage in epiphora patients, which may be the cause of functional epiphora. The etiology of neurogenic damage in the orbicularis oculi muscle requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of orbicularis oculi muscle electromyography in functional epiphora

Liu

Xue

et al. 2020

WJCC

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“…Inflammation was been acknowledged as the most important factor in the pathogenesis of DED [ 3 ]. The infiltration of a large number of lymphocytes in the lacrimal gland and ocular surface as well as the release of inflammatory cytokines can lead to immune-related inflammation, moreover, the production of inflammatory cytokines can damage the normal nerve conduction of tear secretion and affect the quality and quantity of tear secretion, forming a vicious circle [ 4 , 5 ]. A series of studies demonstrated that the levels of various cytokines including TNF-α, IL-1α, IL-1β, IL-6, IL-10, IL-8, and MIP-1α in tears of DED patients were significantly higher than those in normal people [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Tear Luminex Analysis in Dry Eye Patients

Zhao

et al. 2018

Med Sci Monit

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BackgroundThe purpose of this study was to analyze tear inflammatory cytokines of different subclasses of dry eye disease (DED) patients using Luminex technology.Material/MethodsForty-five DED patients including 20 Sjogren syndrome aqueous tear deficiency (SS-ATD) patients, 20 non-Sjogren syndrome aqueous tear deficiency (NSS-ATD) patients, 15 meibomian gland dysfunction (MGD) patients, and 15 normal participants were enrolled in this study. Concentrations of 11 inflammatory cytokines in tear samples of study participants were measured by Luminex assay; ELISA assay was further applied for validation.ResultsThe levels of cytokines were mostly increased (TNF-α, IL-1α, IL-1β, IL-6, IL-8, IL-12P70, IL-13, IFN-γ, and MIP-1α) in DED patients compared with normal participants. And the levels of TNF-α, IL-6, IL-8, and IL-12P70 were significantly elevated in tears of the patient groups compared to tears of participants in the normal group (P<0.05). Statistical differences were also observed among the patient groups (SS-ATD, NSS-ATD, and MGD) for the level of IL-8 and TNF-α. The results of ELISA assay demonstrated the consistence with Luminex assay, confirming the practicality of Luminex technology for the analysis of multiple cytokines in DED patient tears.ConclusionsThe levels of inflammatory cytokines were mostly elevated in DED patients, and statistical differences of some cytokines were also found between SS-ATD, NSS-ATD, and MGD groups, suggesting that inflammatory cytokines could be potential supplements for the diagnosis of DED subclasses and therapeutic targets for DED patients.

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“…The nasolacrimal ducts on the same patient side as the tumor were delineated following the definition by Maliborski et al [13], i.e., the interosseous portion of the nasolacrimal ducts and lacrimal sac ( Fig. 1).…”

Section: Dose-volume Analysis Of the Nasolacrimal Ductmentioning

confidence: 99%

Dosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma

Kubo

Kubota

Kawamura

et al. 2019

Radiotherapy and Oncology

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Background and purpose: Little information is available on the risk factors for nasolacrimal duct obstruction after radiotherapy for head and neck tumors. We investigated the incidence and predictive dosimetric parameters for nasolacrimal duct obstruction following carbon-ion radiotherapy for head and neck tumors. Materials and methods: Twenty-eight patients with head and neck non-squamous cell carcinoma were analyzed in this single-institution prospective study. More than half of the tumors were located in the nasal cavity and maxillary sinus. Carbon-ion radiotherapy consisting of 57.6 or 64.0 Gy(relative biological effectiveness; RBE) in 16 fractions was administered. Nasolacrimal duct obstruction was recorded according to Common Terminology Criteria for Adverse Events version 4.0. Cutoff values were determined using receiver operating characteristic (ROC) curve analysis. VX indicates the volume irradiated with X Gy (RBE). Results: The median follow-up period was 60.3 months. Incidences of Grade 1 and 2 nasolacrimal duct obstructions were 46% (13/28) and 7% (2/28), respectively; no Grade 3 or greater toxicities were recorded. Throughout the dose range, the volumes of the irradiated nasolacrimal ducts were significantly higher in the obstruction-positive patients than in the obstruction-negative patients (p < 0.001 for V10, V20, V30, V40, V50, and V60). Cutoff values determined by the ROC curve analysis classified the obstructionpositive patients with an accuracy of >96% over the entire range of V10-V60. Conclusion: The incidence and predictive dosimetric parameters for nasolacrimal duct obstruction after carbon-ion radiotherapy were demonstrated in a prospective cohort. These data should help optimize carbon-ion radiotherapy treatments for patients with head and neck tumors.

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Diagnostic imaging of the nasolacrimal drainage system. Part I. Radiological anatomy of lacrimal pathways. Physiology of tear secretion and tear outflow

Cited by 48 publications

References 26 publications

Diagnostic value of orbicularis oculi muscle electromyography in functional epiphora

Diagnostic value of orbicularis oculi muscle electromyography in functional epiphora

Tear Luminex Analysis in Dry Eye Patients

Dosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma

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